Impact of TB on the survival of people living with HIV infection in England, Wales and Northern Ireland

Zenner, Dominik; Abubakar, Ibrahim; Conti, Stefano; Rk, Gupta; Yin, Zhihua; Kall, Meaghan; Kruijshaar, Michelle E.; Rice, Brian; Thomas, H Lucy; Pozniak, Anton; Lipman, Marc; Delpech, Valérie

doi:10.1136/thoraxjnl-2014-206452

Cited by 38 publications

(45 citation statements)

References 23 publications

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“…TB-HIV coinfection is not insignificant in the EU/EEA with 1051 TB cases reported with HIV infection (4.9% of all TB cases with a known HIV status) and 436 new AIDS cases with TB as AIDS-defining illness (24.5% of all reported new AIDS cases) in 20 countries in 2014. The USA reported a similar proportion of TB cases with HIV infection in 2014, that is 6% [14], whereas the United Kingdom, which does not report HIV status of TB cases to ECDC and was therefore not included in our analysis, estimated the TB incidence among people living with HIV to be 2.1 per 100 person-years [15]. Proportions of TB cases with an HIV test result who were HIV-positive varied between different WHO regions, from 2.3% in the west eastern Pacific region to 39% in the African region [16].…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis and HIV coinfection in Europe

Werf

Ködmön

Zucs

et al. 2016

Aids

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Objective:To better understand the epidemiology of tuberculosis (TB)/HIV coinfection in the European Union (EU) and European Economic Area (EEA) for planning of prevention and control measures.Design:Analysis of surveillance data.Methods:We performed an analysis of the 2014 TB and AIDS data to assess the burden of TB/HIV coinfection and we applied multivariable logistic regression to evaluate predictors for coinfection.Results:Twenty-one of 31 EU/EEA countries reported HIV testing results for 64.6% of the 32 892 notified TB cases. Of those, 1051 (4.9%) were reported as HIV-positive. Males [adjusted odds ratio (aOR) 1.25; 95% confidence interval (CI) 1.07–1.46] and those in age group 25–44 years were more frequently coinfected. TB cases originating from the WHO African region had the highest proportion of coinfection (aOR 3.28 versus origin in EU/EEA; 95% CI 2.35–4.57). TB treatment was completed successfully by 57.9% of HIV-positive TB cases and 83.5% of HIV-negative cases. In 2014, 3863 cases of AIDS were reported by 29 EU/EEA countries; 691 (17.9%) of these cases presented with TB as an AIDS-defining illness. Persons who had acquired HIV through injecting drug use had higher odds of TB as an AIDS-defining illness (aOR 1.78 versus heterosexual route of transmission; 95% CI 1.37–2.32).Conclusion:TB/HIV coinfection is a substantial problem in the EU/EEA. The occurrence of TB in HIV-positive cases and the low TB treatment success rate suggest that international guidelines for prevention and treatment of TB in HIV-infected adults need to be better implemented.

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Section: Discussionmentioning

confidence: 99%

Tuberculosis and HIV coinfection in Europe

Werf

Ködmön

Zucs

et al. 2016

Aids

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“…The mortality rate in our study was higher for IDUs diagnosed with TB. This is in line with other European reports which also found a greater risk of death in patients with TB, in particular during the first year following HIV diagnosis . Among IDUs with TB, the mortality rate was greatest in those with extra‐pulmonary disease and people with XDR TB.…”

Section: Discussionmentioning

confidence: 97%