Impact of the aquatic pathobiome in low-income and middle-income countries (LMICs) quest for safe water and sanitation practices

Taviani, Elisa; Pedro, Olívia

doi:10.1016/j.copbio.2021.08.015

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…We thus speculate that poor treatment of hospital or sewage wastewater or agricultural run-off may be a source of contamination in the drinking water in Pakistan [ 57 , 59 , 60 ]. In general, in LMICs, the most deadly and common pollutants in drinking water are of biological origin [ 61 ]. For example, a study by McInnes et al (2022) observed human waste as a primary source of AMR in Bangladesh [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study of Potential Antimicrobial Resistance and Ecology in Gastrointestinal and Oral Microbial Communities of Young Normoweight Pakistani Individuals

et al. 2023

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Antimicrobial resistance (AMR) is a major global public health concern mainly affecting low- and middle-income countries (LMICs) due to lack of awareness, inadequate healthcare and sanitation infrastructure, and other environmental factors. In this study, we aimed to link microbial assembly and covariates (body mass index, smoking, and use of antibiotics) to gut microbiome structure and correlate the predictive antimicrobial gene prevalence (piARG) using PICRUSt2. We examined the gastrointestinal and oral microbial profiles of healthy adults in Pakistan through 16S rRNA gene sequencing with a focus on different ethnicities, antibiotic usage, drinking water type, smoking, and other demographic measures. We then utilised a suite of innovative statistical tools, driven by numerical ecology and machine learning, to address the above aims. We observed that drinking tap water was the main contributor to increased potential AMR signatures in the Pakistani cohort compared to other factors considered. Microbial niche breadth analysis highlighted an aberrant gut microbial signature of smokers with increased age. Moreover, covariates such as smoking and age impact the human microbial community structure in this Pakistani cohort.

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Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study of Potential Antimicrobial Resistance and Ecology in Gastrointestinal and Oral Microbial Communities of Young Normoweight Pakistani Individuals

et al. 2023

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“…58,59,56 In general, in LMICs, the most deadly and common pollutants in drinking water are of biological origin. 60 For example, a study by McInnes et al (2022) observed human waste as a primary source of AMR in Bangladesh. 61 We further linked microbial taxa to individual variables (Age, BMI, Smoking, Antibiotic Usage Status, Ethnic groups, and Source of drinking water).…”

Section: Discussionmentioning

confidence: 99%

“…56, 58, 59 In general, in LMICs, the most deadly and common pollutants in drinking water are of biological origin. 60 For example, a study by McInnes et al (2022) observed human waste as a primary source of AMR in Bangladesh. 61…”

Section: Discussionmentioning

confidence: 99%

Cross-sectional study of antimicrobial resistance and ecology in gastrointestinal and oral microbial communities of urban Pakistani adults

Batool

Keating

Javed

et al. 2022

Preprint

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Background and Aims: Antimicrobial resistance (AMR) is one of the most serious global public health threats affecting lower-middle-income countries (LMICs) due to lack of awareness, inadequate healthcare and sanitation infrastructure, plus other environmental factors. In this study, we aimed to link microbial assembly and covariates (body mass index, smoking, use of antibiotics) to gut microbiome structure and correlate AMR gene prevalence. Methods: We examined the gastrointestinal and oral microbial profiles of healthy adults in Pakistan through 16S rRNA gene sequencing with a focus on different ethnicities, antibiotic usage, drinking water type, smoking, and other demographic measures. We then utilised a suite of innovative statistical tools, driven by numerical ecology and machine learning, to address the above aims. Results: We observed tap water as the main contributor for development of AMR in the Pakistani cohort. In addition, microbial niche breadth analysis based on null modelling procedures highlighted an aberrant gut microbial signature of smokers with increased age. Conclusions: Drinking water plays a more important role in AMR spread in Pakistan rather than other factors considered. Moreover, covariates such as smoking, and age impact the human microbial community structure in this Pakistani cohort. To the best of our knowledge, this is one of the first studies that provide a snapshot of the microbiomes of healthy individuals in Pakistan and considers AMR profiles with an emphasis on potential sources of AMR prevalence.

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“…In addition, the typical and harmful pollutants in developing countries are of biological origin, as diseases present in almost 50% of their populations are associated with water, both for supply and sanitation [14]. Worldwide, according to estimations, safe drinking water is unavailable for 1.1 billion people; water scarcity is suffered by 2.7 billion people, and 5 million people die each year due to waterborne infections [15,16].…”

Section: Introductionmentioning

confidence: 99%

Arsenite to Arsenate Oxidation and Water Disinfection via Solar Heterogeneous Photocatalysis: A Kinetic and Statistical Approach

Silerio-Vázquez

Núñez-Núñez

Proal-Nájera

et al. 2022

Water

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Arsenic (As) poses a threat to human health. In 2014, more than 200 million people faced arsenic exposure through drinking water, as estimated by the World Health Organization. Additionally, it is estimated that drinking water with proper microbiological quality is unavailable for more than 1 billion people. The present work analyzed a solar heterogeneous photocatalytic (HP) process for arsenite (AsIII) oxidation and coliform disinfection from a real groundwater matrix employing two reactors, a flat plate reactor (FPR) and a compound parabolic collector (CPC), with and without added hydrogen peroxide (H2O2). The pseudo first-order reaction model fitted well to the As oxidation data. The treatments FPR–HP + H2O2 and CPC–HP + H2O2 yielded the best oxidation rates, which were over 90%. These treatments also exhibited the highest reaction rate constants, 6.7 × 10−3 min−1 and 6.8 × 10−3 min−1, respectively. The arsenic removal rates via chemical precipitation reached 98.6% and 98.7% for these treatments. Additionally, no coliforms were detected at the end of the process. The collector area per order (ACO) for HP treatments was on average 75% more efficient than photooxidation (PO) treatments. The effects of the process independent variables, H2O2 addition, and light irradiation were statistically significant for the AsIII oxidation reaction rate (p < 0.05).

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Impact of the aquatic pathobiome in low-income and middle-income countries (LMICs) quest for safe water and sanitation practices

Cited by 4 publications

References 33 publications

A Cross-Sectional Study of Potential Antimicrobial Resistance and Ecology in Gastrointestinal and Oral Microbial Communities of Young Normoweight Pakistani Individuals

A Cross-Sectional Study of Potential Antimicrobial Resistance and Ecology in Gastrointestinal and Oral Microbial Communities of Young Normoweight Pakistani Individuals

Cross-sectional study of antimicrobial resistance and ecology in gastrointestinal and oral microbial communities of urban Pakistani adults

Arsenite to Arsenate Oxidation and Water Disinfection via Solar Heterogeneous Photocatalysis: A Kinetic and Statistical Approach

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