Impact of the<i>GPX5, FUT1, FSHβ</i>and<i>PRLR</i>Genes on Individual Weight at Birth and 30 Days in Hybrid Pig

Zhang, D. J.; Liu, D.; Yang, G. W.; Fu, X. K.; He, X. M.

doi:10.1080/09712119.2010.10539518

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Thus, the porcine g.1896A allele seems to be a beneficial allele for litter size traits in pigs. These findings are consistent with those of Zhang et al (2010), who reported that GPX5 mutations were not substantially linked with production traits in a population of F1 hybrid pigs. Similarly, Buske et al (2006) did not find association between GPX5 polymorphism and performance traits in commercial F2sows.…”

Section: O N L I N E C O P Ysupporting

confidence: 92%

Novel polymorphisms in GPX5 gene and their association with reproductive and productive traits in Lumsniang (Hampshire x Niang Megha) pigs under subtropical hilly region of Meghalaya

Kumar¹,

Kadirvel²,

Khargharia³

et al. 2022

JEB

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Aim: To detect genetic variants of GPX5 gene and their associations with reproductive and productive traits in the Lumsniang (Hampshire x Niang Megha) pigs. Methodology: In this study, a total of 87 Lumsniang pigs were selected for collecting blood samples (3-5 ml) from Nucleus Pig Breeding Farm of ICAR Research Complex for North Eastern Hilly region, Umiam, Meghalaya. Genomic DNA was extracted from the blood leukocytes using the Qiagen DNeasy Blood and tissue kits and diluted to working concentration (50 ng μl-1) and stored at -20°C, which were used as templates for association of GPX5 variants with polymerase chain reaction. The data for reproductive and productive traits were recorded from all the animals taken in this study. The reproductive and productive traits were analyzed using a general linear model (GLM) procedure of SPSS Version 16.0. Results: Polymorphisms at Intron 1 of the GPX5 gene was determined by PCR-RFLP with HinfI restriction enzyme and DNA sequencing analyses. Two alleles and three genotypes were identified by HinfI digestion of the GPX5 gene. In the SNP-HinfI (g.1896A>G) locus, significant associations were found between GPX5 genotypes and litter size at birth. The genotype AA demonstrated significantly (P<0.05) superior litter size at birth as compared to AG and GG genotypes at the SNP-HinfI locus in Lumsniang pig. Interpretation: The study reported probable associations of GPX5 variants with reproduction and production traits in Lumsniang pig. The genotype AA at locus SNP-HinfI improved the litter size at birth in the studied population. The GPX5 gene may be considered as a DNA marker for marker-assisted selection after validation in a large pig population.

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Section: O N L I N E C O P Ysupporting

confidence: 92%

Novel polymorphisms in GPX5 gene and their association with reproductive and productive traits in Lumsniang (Hampshire x Niang Megha) pigs under subtropical hilly region of Meghalaya

Kumar¹,

Kadirvel²,

Khargharia³

et al. 2022

JEB

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“…Only Zhang et al (2010) analyzed GPX5, FUT1, FSH and PRLR genes in F1 hybrid pigs derived from crosses between wild boars and Large White pigs. Results showed that GPX5 variants were not associated with individual weight at birth and 30 days.…”

Section: Resultsmentioning

confidence: 99%

Association betweenGPX5Gene Polymorphism and Selenium Concentration in Liver and Kidney of Wild Boars from West Pomerania Province, Poland

Terman

Mikolajczyk

Polasik

et al. 2013

Italian Journal of Animal Science

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The aim of the experiment was to detect polymorphism in the GPX5 gene and to determine associations between individual genotypes and selenium concentration in liver and kidney of wild boars from West Pomerania province in Poland. The polymorphism in GPX5 gene was detected using the PCR-RFLP method with specific primers and the restriction enzyme HinfI. Two different alleles of the GPX5 gene were identified -allele 1B (0.37) and 2B (0.63). The relationships between the GPX5 genotypes and concentrations of selenium in liver and kidney were analyzed, revealing statistically significant (P≤0.05) differences between wild boars carrying different GPX5 genotypes in both genders. Obtained results indicated that wild boars with the 2B2B genotype had the highest selenium concentration in livers and kidneys compared to 1B1B and 1B2B animals and these differences were statistically significant (P≤0.05).

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“…In Large White sows, Liu et al, estimated allele B frequency of 0.54 that was higher than that of allele A -0.46 (36). Close results were found for the wild boar and Large White crosses, with lower frequency of allele A (0.44) versus that of allele B (0.56) and predominance of the frequency of the heterozygous PRLR AB genotype: 0.51, as compared to those of both homozygous genotypes -0.19 for PRLR AA and 0.30 for PRLR BB (37). Another study in different pig breeds established higher frequency for allele A in Hungarian Large White and Pietrain breeds (0.63 and 0.59 respectively) than for allele B frequency (0.37 and 0.41).…”

Section: Polymorphism At the Porcine Prlr Locusmentioning

confidence: 61%

Prolactin Receptor Gene (Prlr) Role in Swine Reproduction

Sabev¹

2019

TJS

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PRLR gene has been studied as a candidate gene for litter size in swine because of prolactin biological functions and their association with reproduction. Prolactin receptor gene is mapped on porcine chromosome 16. The established PCR-RFLP polymorphism at PRLR locus demonstrated the presence of two alleles, А and В and three genotypes АА, АВ and ВВ. There were found different allele and genotype frequencies in different pig populations with variation of the effects of PRLR genotypes on litter traits. Additional studies should be done in specific breeds and populations to evaluate the association of existing PRLR locus polymorphism with reproductive traits before application of marker-assisted selection in these populations.

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Impact of theGPX5, FUT1, FSHβandPRLRGenes on Individual Weight at Birth and 30 Days in Hybrid Pig

Cited by 4 publications

References 10 publications

Novel polymorphisms in GPX5 gene and their association with reproductive and productive traits in Lumsniang (Hampshire x Niang Megha) pigs under subtropical hilly region of Meghalaya

Novel polymorphisms in GPX5 gene and their association with reproductive and productive traits in Lumsniang (Hampshire x Niang Megha) pigs under subtropical hilly region of Meghalaya

Association betweenGPX5Gene Polymorphism and Selenium Concentration in Liver and Kidney of Wild Boars from West Pomerania Province, Poland

Prolactin Receptor Gene (Prlr) Role in Swine Reproduction

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