Impact of three-dimensional tortuous pore structure on polyethersulfone membrane morphology and mass transfer properties from a manufacturing perspective

Fukuda, Makoto; Saomoto, Hitoshi; Mori, Tomohiro; Yoshimoto, Hiroyuki; Kusumi, Rei; Sakai, Kiyotaka

doi:10.1007/s10047-019-01144-0

Cited by 14 publications

(23 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(3): cited from [3] Thus, in the hemoconcentration membrane fouling process in this experiment, slight changes in the pore structure of the thick part of the membrane were noted, despite the protein adsorption layer on the fouling pore inlets (surface fouling, external). There was little internal pore blocking (pore blocking, internal) ( Fig.5).…”

Section: Discussion 41 Change In Pore Structure and Mass Transfer Prmentioning

confidence: 79%

“…The sieving coefficient (SC) was measured using the method reported in our previous study [3].1 h after starting the irrigation, the blood side inlet concentration, outlet concentration, and filtrate side concentration of the solute were measured.…”

Section: Discussion 41 Change In Pore Structure and Mass Transfer Prmentioning

confidence: 99%

“…The method reported in our previous study [3,20] was employed to observe the inner surface of hollow fiber membranes. Before bovine blood contact, the hemoconcentrators were washed by feeding sterile RO water at 200 mL/min for 30 min.…”

Section: Observation Of Three-dimensional Tortuous Pore Using An Spm mentioning

confidence: 99%

“…Hemoconcentration membranes used in extracorporeal circulatory surgeries require a membrane pore structure design with a high pure water permeability, which does not allow useful proteins such as albumin to leak out [1][2]. However, studies on hemoconcentration membranes have not been conducted yet, and therefore, we were interested in pore structures before and after blood contact due to protein fouling [3].…”

Section: Introductionmentioning

confidence: 99%

“…We could successfully observe the 3D tortuous pore structures of hemoconcentration membranes and measure pore diameter and distribution [3,20].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Validity of Three-Dimensional Tortuous Pore Structure and Fouling of Hemoconcentration Capillary Membrane Using the Tortuous Pore Diffusion Model and Scanning Probe Microscopy

Fukuda¹,

Yoshinoto²,

Saomoto³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Hemoconcentration membranes used in cardiopulmonary bypass require a pore structure design with high pure water permeability, and which does not allow protein adsorption and useful protein loss. However, studies on hemoconcentration membranes have not been conducted yet. The purpose of this study was to analyze three-dimensional pore structures and protein fouling before and after blood contact with capillary membranes using the tortuous pore diffusion model and a scanning probe microscope system. We examined two commercially available capillary membranes of similar polymer composition that are successfully used in hemoconcentration clinically. Assuming the conditions of actual use in cardiopulmonary bypass, we perfused these membranes with bovine blood. Pure water permeability before and after bovine blood perfusion was measured using the dead-end filtration. The scanning probe microscopy system was used for analysis. High-resolution three-dimensional pore structures on the inner surface of the membranes were observed before blood contact. On the other hand, pore structures after blood contact could not be observed due to protein fouling. The pore diameters calculated by the tortuous pore diffusion model and scanning probe microscopy were mostly similar and could be validated reciprocally. Achievable pure water permeabilities showed no difference despite protein fouling, leading to low values of albumin SC. This is due to the mechanism that protein fouling occurs on the membrane surface, while there is little internal pore blocking. Therefore, controlling the fouling is essential for membranes in medical use. These characteristics of the hemoconcentration membranes examined in this study are suitable for clinical use.

show abstract

Section: Discussion 41 Change In Pore Structure and Mass Transfer Prmentioning

confidence: 79%

Section: Discussion 41 Change In Pore Structure and Mass Transfer Prmentioning

confidence: 99%

Section: Observation Of Three-dimensional Tortuous Pore Using An Spm mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…We could successfully observe the 3D tortuous pore structures of hemoconcentration membranes and measure pore diameter and distribution [3,20].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Validity of Three-Dimensional Tortuous Pore Structure and Fouling of Hemoconcentration Capillary Membrane Using the Tortuous Pore Diffusion Model and Scanning Probe Microscopy

Fukuda¹,

Yoshinoto²,

Saomoto³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Replication of fouling in vitro in hollow fiber dialyzers by albumin immobilization

2022

View full text Add to dashboard Cite

Evolutions of extracorporeal membrane oxygenator (ECMO): perspectives for advanced hollow fiber membrane

Fukuda

2023

J Artif Organs

View full text Add to dashboard Cite

Impact of three-dimensional tortuous pore structure on polyethersulfone membrane morphology and mass transfer properties from a manufacturing perspective

Cited by 14 publications

References 21 publications

Validity of Three-Dimensional Tortuous Pore Structure and Fouling of Hemoconcentration Capillary Membrane Using the Tortuous Pore Diffusion Model and Scanning Probe Microscopy

Validity of Three-Dimensional Tortuous Pore Structure and Fouling of Hemoconcentration Capillary Membrane Using the Tortuous Pore Diffusion Model and Scanning Probe Microscopy

Replication of fouling in vitro in hollow fiber dialyzers by albumin immobilization

Evolutions of extracorporeal membrane oxygenator (ECMO): perspectives for advanced hollow fiber membrane

Contact Info

Product

Resources

About