Impact of Types of Moisturizer and Humidity on the Residual Weight and Viscosity of Liquid and Gel Oral Moisturizers

Abstract

Because viscosity of gel moisturizers increases as weight decreases, selecting gel moisturizers with a minimal change in weight and viscosity would be preferable in the case of a long-time application and severe dry mouth.

Impact of Type and Duration of Application of Commercially Available Oral Moisturizers on Their Antifungal Effects

“…Okura et al examined the relationship between the viscosity and temperature of oral moisturizers and reported that the viscosity of moisturizers fell as their temperature rose . Thus, in the present study, oral moisturizers were stored in an incubator at 37°C to simulate the oral cavity . The growth‐inhibitory zones of the 8‐hour group were significantly smaller than those of the 0‐hour group (except for gel moisturizers), suggesting that the temperature in the incubator affected the antifungal agents in the liquid moisturizers.…”

“…For patients with dry mouth resulting from radiotherapy or Sjogren's syndrome, pilocarpine and cevimeline are prescribed to promote saliva secretion . These drugs, however, cause adverse side effects such as hyperhidrosis and dyspepsia, so that oral moisturizers are frequently required . In the present study, we focused on the antifungal effects of oral moisturizers to reduce the risk of C. albicans infection, which is common among dry mouth patients.…”

“…For the 8‐hour group, 5 ml samples were measured by a pipette and infused into polypropylene mini cups (No. 5; AS ONE, Osaka, Japan) and stored in an incubator (Direct heat CO 2 incubator #310; Thermo Fisher Scientific K K, Tokyo, Japan) at 37°C and 85% relative humidity . The final range of the AMPH‐B concentration test using dimethyl sulfoxide dilution was 2.5 to 0.08 μg/ml .…”

“…The final range of the AMPH‐B concentration test using dimethyl sulfoxide dilution was 2.5 to 0.08 μg/ml . All samples were stored at 37°C prior to the experiment, and all measurements were conducted in an experimental room maintained at 26°C with a commercially available air conditioner …”

“…Physical properties of oral moisturizers, such as viscosity and transpiration rate, are important when selecting products, because these characteristics are closely related to the ease of mucosal application and moisture content . In a previous study, we found that there was no correlation between the rate of change in weight and the rate of change in viscosity of liquid moisturizers; however, a significant negative correlation was found between the rate of change in weight and the rate of change in viscosity of gel‐type moisturizers with time . It is possible that changes in oral moisturizers over time affect their antifungal effects.…”