Impaired Aortic Elastic Properties in Patients with Chronic Graft-versus-Host Disease

Doğdu, Orhan; Kaya, Mehmet; Yarlıoğlueş, Mikail; Doğan, Ali; Ardıç, İdris; Elçik, Deniz; Kalay, Nihat; Kaynar, Leylagül; Kurnaz, Fatih; Eryol, Namık Kemal

doi:10.1111/j.1540-8175.2011.01475.x

Cited by 2 publications

(1 citation statement)

References 54 publications

(90 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, our present study is the first to study directly the mechanical properties of mesenteric resistance arteries in acute GVHD. In chronic GVHD, a study in humans evaluated the compliance of the aorta via ultrasound [43]. In contrast to our study, they found an increased arterial stiffness in patients with disease duration of about 15 months.…”

Section: Endothelial Dysfunction In Gvhdcontrasting

confidence: 99%

Endothelial Dysfunction and Altered Mechanical and Structural Properties of Resistance Arteries in a Murine Model of Graft-versus-Host Disease

Schmid

Bouazzaoui

Doser

et al. 2014

Biology of Blood and Marrow Transplantation

View full text Add to dashboard Cite

A putative involvement of the vasculature seems to play a critical role in the pathophysiology of graft-versus-host disease (GVHD). We aimed to characterize alterations of mesenteric resistance arteries in GVHD in a fully MHC-mismatched model of BALB/c mice conditioned with total body irradiation that underwent transplantation with bone marrow cells and splenocytes from syngeneic (BALB/c) or allogeneic (C57BL/6) donors. After 4 weeks, animals were sacrificed and mesenteric resistance arteries were studied in a pressurized myograph. The expression of endothelial (eNOS) and inducible nitric oxide (NO)-synthase (iNOS) was quantified and vessel wall ultrastructure was investigated with electron microscopy. The myograph study revealed an endothelial dysfunction in allogeneic-transplant recipients, whereas endothelium-independent vasodilation was similar to syngeneic-transplant recipients or untreated controls. The expression of eNOS was decreased and iNOS increased, possibly contributing to endothelial dysfunction. Additionally, arteries of allogeneic transplant recipients exhibited a geometry-independent increase in vessels strain. For both findings, electron microscopy provided a structural correlate by showing severe damage of the whole vessel wall in allogeneic-transplant recipient animals. Our study provides further data to prove, and is the first to characterize, functional and structural vascular alterations in the early course after allogeneic transplantation directly in an ex vivo setting and, therefore, strongly supports the hypothesis of a vascular form of GVHD.

show abstract

Section: Endothelial Dysfunction In Gvhdcontrasting

confidence: 99%