Impaired declarative memory for emotional material following bilateral amygdala damage in humans.

Adolphs, Ralph; Cahill, Larry; Schul, Rina; Babinsky, Ralf

doi:10.1101/lm.4.3.291

Cited by 345 publications

(141 citation statements)

References 37 publications

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“…Pharmacological, lesion, and neuroimaging studies have implicated the human amygdala in the emotional enhancement of episodic memory (22,24,(48)(49)(50)(51)(52)(53)(54)(55) via influences on the hippocampal formation (56,57). Consistent with the present findings, many studies now suggest that amygdala activation near the inception of memory consolidation is correlated with enhanced long term memory.…”

Section: Discussionsupporting

confidence: 78%

Emotion enhances remembrance of neutral events past

Anderson

Wais

Gabrieli

2006

Proc. Natl. Acad. Sci. U.S.A.

221

218

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Emotional events are bestowed with special prominence in memory. This may reflect greater attention oriented to these events during encoding, and͞or enhancement of memory consolidation after emotional events have passed. Here we show invoked emotional arousal results in a retrograde enhancement of long-term memory, determining what will later be remembered or forgotten. Subjects saw pictures of neutral faces and houses followed by emotionally arousing scenes at varying intervals. Self-reported emotional arousal responses predicted a retrograde enhancement of memory for preceding neutral events in a 1-week delayed recognition memory test. At longer picture-scene intervals, no enhancement was found, implicating a critical window in which emotional arousal must occur for retrograde memory enhancement. Postencoding manipulation of emotional arousal specifically enhanced conscious recollection rather than familiarity-based discrimination. An additional study revealed no retrograde enhancement for pictures preceding highly memorable, but nonarousing, distinctive scenes. These findings indicate an important role for emotional arousal in the postencoding enhancement of episodic memory consolidation.amygdala ͉ consolidation ͉ hippocampus ͉ memory ͉ arousal

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Section: Discussionsupporting

confidence: 78%

Emotion enhances remembrance of neutral events past

Anderson

Wais

Gabrieli

2006

Proc. Natl. Acad. Sci. U.S.A.

221

218

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“…Thus, patients with bilateral amygdala damage do not show an advantage in subsequent recall of emotional items and events (33,34). The critical role of the amygdala is also evidenced by functional neuroimaging experiments where engagement of the amygdala during encoding predicts later recall of emotional material (35,36).…”

Section: Emotion Memory and Learningmentioning

confidence: 78%

Emotion, Cognition, and Behavior

Dolan

2002

Science

1,584

928

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Emotion is central to the quality and range of everyday human experience. The neurobiological substrates of human emotion are now attracting increasing interest within the neurosciences motivated, to a considerable extent, by advances in functional neuroimaging techniques. An emerging theme is the question of how emotion interacts with and influences other domains of cognition, in particular attention, memory, and reasoning. The psychological consequences and mechanisms underlying the emotional modulation of cognition provide the focus of this article.

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“…Amygdala activity during the encoding of emotionally salient stimuli is predictive of subsequent memory [53], and damage to the amygdala abolishes the EEM [55]. The neurobiological correlates of the interaction between age and the emotional valence of stimuli are unknown.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Aging and Alzheimer's Disease on Emotional Enhancement of Memory

Baran

Cangöz²,

Ozel-Kizil³

2014

Eur Neurol

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Emotional enhancement of memory (EEM) has been a well-known phenomenon which corresponds to the advantage of emotional stimuli to be better recalled than neutral ones. Previous studies suggest that aging favours recollection of positive items and this pattern is disrupted in Alzheimer's disease (AD). Emotional valence of different stimulus modalities, i.e. pictures and words, may also have an effect on each other's memory performances. However, none of these were clearly studied in AD. This study aimed to evaluate how emotional valences of simultaneously presented stimuli affected recall in healthy young (YG, n = 30), healthy elderly (HE, n = 30) participants and in patients with AD (n = 30). A battery consisting of emotional words presented on emotional pictures was developed. An analysis of a 3 (Groups) × 3 (Emotional Valence of Picture) × 3 (Emotional Valence of Word) mixed ANOVA design was carried out. Patients with AD could process emotional information similarly to healthy participants; however, they had EEM only for picture recalling. Emotional valence of the co-presented stimulus had a boosting effect both in the YG and HE, but not in AD group, especially if both of the stimuli had the same emotional valence. This study highlights the impaired EEM for verbal and preserved EEM for non-verbal declarative memory in patients with AD, the neurobiological underpinnings of which should be addressed by future studies.

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Impaired declarative memory for emotional material following bilateral amygdala damage in humans.

Cited by 345 publications

References 37 publications

Emotion enhances remembrance of neutral events past

Emotion enhances remembrance of neutral events past

Emotion, Cognition, and Behavior

The Impact of Aging and Alzheimer's Disease on Emotional Enhancement of Memory

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