Impaired sleep quality and cognition in patients of Parkinson's disease with REM sleep behavior disorder: a comparative study

Kamble, Nitish; Yadav, Ravi; Lenka, Abhishek; Kumar, Keshav; Nagaraju, B C; Pal, Pramod Kumar

doi:10.1016/j.sleep.2019.04.001

Cited by 18 publications

(20 citation statements)

References 26 publications

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“…Two studies ( 63 , 66 ) did not provide either measure of motor symptoms or disease stage for the entire sample. PSG was used in 18 studies alone or combined with the clinical interview ( 5 , 15 , 16 , 35 , 54 , 57 , 58 , 60 , 61 , 63 , 66 – 68 , 70 – 73 , 82 ). The remainder adopted sleep questionnaires and/or clinical interviews to identify Probable-RBD.…”

Section: Resultsmentioning

confidence: 99%

“…The remainder adopted sleep questionnaires and/or clinical interviews to identify Probable-RBD. Ten studies ( 16 , 33 , 57 – 59 , 61 , 69 , 70 , 78 , 82 ) particularly pointed out the utilization of clonazepam.…”

Section: Resultsmentioning

confidence: 99%

“…In the global cognitive function domain, among the enrolled primary studies, eight ( 33 , 60 , 61 , 69 , 71 – 74 ) employed both the MMSE and MOCA. Because the sensitivity of the MOCA is higher than that of the MMSE in evaluating cognitive decline in PD ( 98 – 100 ), we analyzed the MOCA results of these eight studies.…”

Section: Discussionmentioning

confidence: 99%

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Association Between REM Sleep Behavior Disorder and Cognitive Dysfunctions in Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studies

Mao

Huang

et al. 2020

Front. Neurol.

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Background: Rapid eye movement sleep behavior disorder (RBD) is thought to be a prodromal symptom of Parkinson's disease (PD). RBD is also thought to be involved in cognitive decline and dementia in PD. In PD, although the relationship between RBD and cognitive dysfunctions was confirmed by considerable studies, whether RBD was associated with distinct types of cognitive defects is worth of study. Objectives: This systematic review summarizes the evidence relating to cognitive dysfunction in PD patients with RBD (PD-RBD) and those without and explores their specificity to cognitive domains. Methods: A meta-analysis using a random-effects model was performed for 16 different cognitive domains, including global cognitive function, memory (long-term verbal recall, long-term verbal recognition, long-term visual recall, short-term spatial recall, and short-term verbal recall), executive function (general, fluid reasoning, generativity, shifting, inhibition, and updating), language, processing speed/complex attention/working memory, visuospatial/constructional ability, and psychomotor ability. The cognitive difference between the groups of patients was measured as a standardized mean difference (SMD, Cohen's d). PD-RBD patients were classified into Confirmed-RBD (definite diagnosis with polysomnography, PSG) and Probable-RBD (without PSG re-confirmation). In some domains, RBD patients could not be analyzed separately due to the exiguity of primary studies; this analysis refers to such RBD patients as "Mixed-RBD." Results: Thirty-nine studies with 6,695 PD subjects were finally included. Confirmed-RBD patients showed worse performance than those without in global cognitive function, long-term verbal recall, long-term verbal recognition, generativity, inhibition, shifting, language, and visuospatial/constructional ability; Probable-RBD, in global cognitive function and shifting; and Mixed-RBD, in long-term visual recall, Mao et al. RBD and Cognition in PD? short-term spatial recall, general executive function, and processing speed/complex attention/working memory. Conclusion: This meta-analysis strongly suggests a relationship between RBD, Confirmed-RBD in particular, and cognitive dysfunctions in PD patients. Early and routine screening by sensitive and targeted cognitive tasks is necessary for all PD-RBD patients because it may offer the therapeutic time window before they evolve to irreversible dementia.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Association Between REM Sleep Behavior Disorder and Cognitive Dysfunctions in Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studies

Mao

Huang

et al. 2020

Front. Neurol.

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“…Several studies have investigated the impact of RBD on cognitive functioning in PD [18][19][20][21][22]. While differing in the domains examined and the measures used, these studies identified that RBD in PD is most consistently associated with poorer performance on executive functioning, attention, verbal learning and memory, and visuospatial processing tasks [18][19][20]23].…”

Section: Introductionmentioning

confidence: 99%

“…The impact of RBD on sleep quality has been a common question in the literature. Some studies have investigated the impact of RBD on polysomnographic sleep measures and found that RBD was associated with more night-time awakenings and decreased sleep duration, particularly in REM sleep [14,21,24]. However, other studies found that RBD was not associated with some sleep measures, such as sleep latency and sleep efficiency [14,25].…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairments and Self-Reported Sleep in Early-Stage Parkinson’s Disease with Versus without Probable REM Sleep Behavior Disorder

et al. 2019

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Parkinson's disease (PD) is associated with cognitive and sleep impairments. The presence of rapid eye movement (REM) sleep behavior disorder (RBD) symptoms may represent a worse disease prognosis for PD individuals. We investigated cognitive functioning and self-reported sleep in early-stage PD individuals with (n = 19) or without (n = 31) probable RBD. Probable RBD was defined as >5 on the REM Sleep Behavior Disorder Screening Questionnaire. Inhibition, visuospatial cognitive abilities, working memory, sustained visual attention, verbal fluency, and episodic memory were assessed. Sleep impairments were assessed using the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Patient-Reported Outcomes Measurement Information System questionnaires. Chi-squared, Mann-Whitney U, and independent sample t-tests were employed to assess group differences. Participants with PD and probable RBD performed significantly worse on word reading and switching verbal fluency tasks than PD participants without probable RBD (p < 0.05). No significant differences were found in mood, PD severity, or sleep measures between PD individuals with or without probable RBD. Cognitive tasks that involve verbal or switching components may be most impaired in PD individuals with probable RBD. Larger samples are needed to determine whether other cognitive domains and sleep features are significantly associated with RBD in PD.

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Sleep Disorders and Cognitive Dysfunctions in Parkinson’s Disease: A Meta-Analytic Study

et al. 2021

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Impaired sleep quality and cognition in patients of Parkinson's disease with REM sleep behavior disorder: a comparative study

Cited by 18 publications

References 26 publications

Association Between REM Sleep Behavior Disorder and Cognitive Dysfunctions in Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studies

Association Between REM Sleep Behavior Disorder and Cognitive Dysfunctions in Parkinson's Disease: A Systematic Review and Meta-Analysis of Observational Studies

Cognitive Impairments and Self-Reported Sleep in Early-Stage Parkinson’s Disease with Versus without Probable REM Sleep Behavior Disorder

Sleep Disorders and Cognitive Dysfunctions in Parkinson’s Disease: A Meta-Analytic Study

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