2002
DOI: 10.1046/j.1464-5491.2002.00715.x
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Impaired vascular reactivity is present despite normal levels of von Willebrand factor in patients with uncomplicated Type 2 diabetes

Abstract: Impaired vascular reactivity is present in uncomplicated Type 2 diabetes and seems to be a more sensitive marker of vascular dysfunction than von Willebrand factor.

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Cited by 19 publications
(8 citation statements)
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“…Concentrations of vWF were similar between groups. This is supported by a study of individuals with type 2 diabetes mellitus with endothelial dysfunction but unaffected vWF concentrations [34]. We found elevated homocysteine in the FDR subjects compared with CON, which agrees with studies on other prediabetic individuals [35] with endothelial dysfunction.…”
Section: Discussionsupporting
confidence: 87%
“…Concentrations of vWF were similar between groups. This is supported by a study of individuals with type 2 diabetes mellitus with endothelial dysfunction but unaffected vWF concentrations [34]. We found elevated homocysteine in the FDR subjects compared with CON, which agrees with studies on other prediabetic individuals [35] with endothelial dysfunction.…”
Section: Discussionsupporting
confidence: 87%
“…The nitroglycerin response was lower in both the HIVinfected and the diabetic patients compared with the control patients. Impaired smooth muscle responsiveness has been observed previously in patients with type 2 diabetes (37). No difference in nitroglycerin responsiveness was observed between both HIV-infected groups and the diabetic patients, allowing comparisons in endothelial function assessed by FMD between these groups.…”
Section: As the Survival Of Patients With Hiv Increases It Is Becomimentioning
confidence: 64%
“…This hypothesis is supported by our finding of a higher prevalence of left atrial or appendage thrombi in diabetic than in nondiabetic patients. Endothelial dysfunction, reported to be associated with diabetes, could be a further explanation for the higher risk of stroke in diabetic compared with nondiabetic patients with AF [39,40]. Furthermore, diabetic cardiomyopathy might contribute to cardiac dysfunction and thus lead to blood stasis and thrombus formation [40,41].…”
Section: Discussionmentioning
confidence: 97%