2013
DOI: 10.1095/biolreprod.113.109447
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Impairment of the Interleukin System in Equine Endometrium During the Course of Endometrosis1

Abstract: The aim of the study was to characterize endometrial mRNA transcription, immunolocalization, and protein expression of interleukin (IL) 1alpha, IL1beta, IL6, and IL1RI, IL1RII, and IL6Ralpha/beta in the course of endometrosis during the estrous cycle. Additionally, the influence of IL1alpha, IL1beta, and IL6 on prostaglandin (PG) secretion and PG synthase mRNA transcription in endometrial tissue during endometrosis was investigated. The endometrial samples were obtained at the early (n = 12), mid- (n = 12), an… Show more

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Cited by 32 publications
(29 citation statements)
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“…The sequences for equine IL-1RI , IL-1RII , IL-6R β , and ACTB primers were previously published [23]. After a preliminary study, ACTB was chosen as the best housekeeping gene.…”
Section: Methodsmentioning
confidence: 99%
“…The sequences for equine IL-1RI , IL-1RII , IL-6R β , and ACTB primers were previously published [23]. After a preliminary study, ACTB was chosen as the best housekeeping gene.…”
Section: Methodsmentioning
confidence: 99%
“…; Szóstek et al. ). Changes noted in the expression of interleukins (IL)1‐ α , IL‐1 β , IL‐6 and their receptors in endometrium with different degrees of fibrosis and/or inflammation, might be oestrous‐cycle hormone dependent (Szóstek et al.…”
Section: Physiopathologic Mechanisms Of Endometrosismentioning
confidence: 97%
“…Changes noted in the expression of interleukins (IL)1‐ α , IL‐1 β , IL‐6 and their receptors in endometrium with different degrees of fibrosis and/or inflammation, might be oestrous‐cycle hormone dependent (Szóstek et al. ). However, early after breeding, a lower mRNA expression of IL‐6 and IL‐10 was detected in susceptible to persistent breeding‐induced endometritis mares, in which endometrosis animals were included (Woodward et al.…”
Section: Physiopathologic Mechanisms Of Endometrosismentioning
confidence: 99%
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“…On the other hand, cytokines play an important role in the reproductive processes [39]. The complexity of their regulation is due to pleiotropism of cytokines, where each cytokine has multiple target cells of different organs and where responses may differ according to cell type.…”
Section: Immunity and Uterine Defensementioning
confidence: 99%