Implementación de un cuestionario de calidad de vida relacionada con la salud para niños y adolescentes con enfermedad celíaca

ObjectiveA gluten-free diet is the only treatment option of coeliac disease, but recently an increasing number of trials have begun to explore alternative treatment strategies. We aimed to review the literature on coeliac disease therapeutic trials and issue recommendations for outcome measures.DesignBased on a literature review of 10 062 references, we (17 researchers and 2 patient representatives from 10 countries) reviewed the use and suitability of both clinical and non-clinical outcome measures. We then made expert-based recommendations for use of these outcomes in coeliac disease trials and identified areas where research is needed.ResultsWe comment on the use of histology, serology, clinical outcome assessment (including patient-reported outcomes), quality of life and immunological tools including gluten immunogenic peptides for trials in coeliac disease.ConclusionCareful evaluation and reporting of outcome measures will increase transparency and comparability of coeliac disease therapeutic trials, and will benefit patients, healthcare and the pharmaceutical industry.

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Outcome measures in coeliac disease trials: the Tampere recommendations

Ludvigsson

Ciacci

Green

et al. 2018

Gut

107

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The Modern Face of Celiac Disease. What Should an Internist Know?

Matkovska

Глушко

Гавриш

et al. 2018

FMEP

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The World Gastroenterology Organization regards celiac disease as a chronic multicomponent autoimmune disease of the predominantly proximal small intestine, which develops with the use of products containing gluten. Celiac disease is difficult to diagnose due to the multisymptomatic course that can change throughout life. Celiac disease is inherited in an autosomal dominant manner with incomplete penetrance. There are new approaches to the treatment of celiac disease, based on some immune pathogenetic links. In particular, the ways of influencing the intraluminal digestion of gluten, the improvement of barrier functions, the effectiveness of immunomodulators are being studied. Patients should be advised to carefully check the contents of the ingredients before purchasing products.

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Assessing Health-Related Quality of Life in Children with Coeliac Disease: The Italian Version of CDDUX

et al. 2021

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We aimed to assess Health-Related Quality of Life (HRQoL) of Italian children and their parents with coeliac disease (CD) using the Coeliac Disease Dutch Questionnaire (CDDUX). The CDDUX underwent a cross-cultural adaptation in a multi-step process, according to international guidelines. A total of 224 children aged between 8–18 years and their parents were prospectively recruited. Cronbach α coefficient was determined as a measure of internal consistency of the questionnaire and inter-children/parent reliability by intraclass correlation coefficient. Univariate and bivariate regression models were used to evaluate correlations between clinical variables and children and parents subclasses of CDDUX and overall mean Paediatric Quality of Life Inventory (PedsQL). The Italian CDDUX proved to be valid and reliable, mean CDDUX total score revealing a neutral evaluation of the quality of life in children 52.6 ± 17.2 and parents 49.5 ± 17.9 (p = 0.07) with strong correlation with PedsQL. The only clinical variable which appeared to affect significantly quality of life both in children and parents was the lower age. A comparison with our results showed remarkable differences in the HRQoL of populations of various nationalities. The Italian version of the CDDUX questionnaire is a simple and reliable tool for assessing the HRQoL in children and adolescents with CD.

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Implementación de un cuestionario de calidad de vida relacionada con la salud para niños y adolescentes con enfermedad celíaca

Cited by 4 publications

References 15 publications

Outcome measures in coeliac disease trials: the Tampere recommendations

Outcome measures in coeliac disease trials: the Tampere recommendations

The Modern Face of Celiac Disease. What Should an Internist Know?

Assessing Health-Related Quality of Life in Children with Coeliac Disease: The Italian Version of CDDUX

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