Food supply chains are highly distributed, collaborative, heterogeneous, diverse, and varied by product, process, and destination. The global food supply chain (FSC) objective is to maintain a good balance between supply and demand and move products from producer to market. However, sustainability of the FSC has become a major concern as limited resources and increasing population pressure threaten its existence. Supply chain management is an important issue for FSC due to information flow throughout the supply chain. Industry-specific characteristics and extensive integration among multiple actors in an entire supply chain exacerbate this situation. The agri-food sector has one of the lowest rates of information technology penetration for innovation. Over the past thirty years, information and communication technology (ICT) has been introduced into the agricultural and food sectors, helping to improve food production and transportation. However, there are various challenges, such as transparency, accountability, food scandal, trust, and inefficient information flow, that the food supply chain is still facing in reaching sustainable goals. The complexity of food supply systems and the opportunities and challenges faced regarding desired sustainability performance need to be examined to achieve the United Nations Sustainable Development Goals (SDGs). Blockchain is an emerging and disruptive digital technology that can transform governance and sustainability in integrated food supply chains. It provides a transparent, immutable, and traceable ledger that minimizes anomalies and information fraud, making it a potential solution for designing a transparent, traceable food system. Blockchain can potentially improve the sustainability of the food supply chain by providing a transparent traceability system. Food traceability is important for managing the food supply chain and protecting public health. It allows quick and accurate traceability of contaminated food that causes foodborne illness outbreaks, leading to the withdrawal of contaminated food from markets. Blockchain can achieve traceability, provenance tracking, transparency, and reduce environmental impact in the food supply chain. It also helps in achieving sustainable development goals set by the UN. However, there is no scientific research on blockchain’s contribution to achieving these goals in the food supply chain. Therefore, this article presents a systematic literature review and thematic analysis to study the relationship between FSC sustainability, blockchain, and sustainable development goals.