Implementation of DSI FinePointe® whole body plethysmography method in freely moving rats

Fares, Raafat; Bory, Christophe; Valgalier, Christophe; Baudet, Stéphane

doi:10.1016/j.vascn.2019.05.148

Cited by 4 publications

(2 citation statements)

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“…While the hourly and daily mass levels of PM 2.5 were found to be lower than 75 µg m −3 during the sampling period from 31 March to 2 April 2018. The respiratory function parameters include respiratory rate, tidal inhaled volume, minute volume, index of constriction, expiratory pause time, peak expiratory time, estimated peak inspiratory flow, estimated peak expiratory flow, inspiratory time, expiratory time, expiratory flow at 50%, expired volume, relaxation time, duration of breaking, duration of pause before inspiration, and rejection index for Swiss white mouse in the control group and the exposure group were estimated using whole-body plethysmography system (DSI Buxco, Wilmington, NC, USA) [24,25]. The measurements of the respiratory function parameters could be performed on the Swiss white mouse with a clear mind and unbound condition to eliminate the results interfered with by the stress response to the mouse by the trained staff [24].…”

Section: Respiratory Function Parametersmentioning

confidence: 99%

“…The system pressure signal from the plethysmography was calibrated before each recording by injecting 50 mL of air into the system with a calibrated syringe in the large chamber of the whole-body plethysmography system. The independent calibration of each measurement was carried out automatically with the standard integral settings of the "Integral Channel Calculation module" of the whole-body plethysmography system [24,25]. The calculation module collects all data points and resets each cycle whereby the integral is reset each time the source signal passes from zero to a positive value.…”

Section: Respiratory Function Parametersmentioning

confidence: 99%

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The Effects of Indoor Air Filter on Reductions in PM2.5 Associated Health Risks of Respiratory Function in Mouse

Yang

Liu

et al. 2022

Atmosphere

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This study aimed to assess whether protective measures could reduce the health risks of air pollution in mice living in the chambers situated at a suburban site in Beijing. The living chambers of mice were divided into four groups: male mice with and without the high-efficiency particulate air (HEPA) filter (male group A and group B), as well as female mice with and without the HEPA filter (female group A and group B). The experiment was carried out from 1 December 2017 to 31 May 2018. Parameters of respiratory function during periods of clean air and air pollution were determined for all groups to evaluate the role of the indoor air filter (i.e., HEPA) in protection against respiratory health risks in mice. Significant differences in minute volumes were observed in male and female groups with versus without the HEPA. Additionally, respiratory health parameters including respiratory rate, duration of breaking, expiratory time, and relaxation time exhibited differences in female groups with HEPA versus without HEPA. Levels of inflammatory factors in the lungs were measured for all groups after 6months of exposure. Greater mean levels of IL-6 and TNF-α were found in the male groups without HEPA than in those with HEPA. Higher average concentrations of IL-6, T-AOC, SOD, GSH-Px, LDH, TNF-α, and TGF-β1 were found in the female group without HEPA than those without HEPA. Our study has proved the effective protection provided by indoor air filters (i.e., HEPA filters) in reducing respiratory health risks associated with PM2.5.

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Section: Respiratory Function Parametersmentioning

confidence: 99%

Section: Respiratory Function Parametersmentioning

confidence: 99%