Information analysis tasks are becoming increasingly complex as the growth in volume and variety of available data continues to outpace methods to automatically analyze it. The result is an increasing burden on knowledge workers. Industry and academia are currently lacking platforms and tools that can help provide enterprise-wide understanding of how humans analyze information. Through instrumentation of knowledge worker's activities during analysis tasks, we can enable research into techniques that address this need.Several research and design challenges need to be addressed, however, to develop scalable, robust and efficient instrumentation methods for collecting streaming data on relevant humanmachine interactions. This data is typically high volume and multi-modal. We present an instrumentation platform to meet these and future challenges in better understanding and improving the craft of information analysis. Our platform provides an extensible framework to instrument analyst's workstations during information processing tasks, and includes a streaming data processing pipeline that supports real-time analysis of large volumes of event data. We have built the instrumentation platform using the latest open-source scalable and flexible web components and hardware infrastructure. Researchers from science, engineering, and humanities are using our platform to gain insight into tool usage, analytical workflows, and collaboration patterns. Several use cases from these groups are described. Our platform provides a unique, pragmatic and holistic foundation to understand the behavior of knowledge workers, and to support applications that assist with information analysis.