Implications of mean platelet volume in health and disease: A large population study on data from National Health and Nutrition Examination Survey

Ball, Somedeb; Arévalo, Maria T.; Wongsaengsak, Sariya; Dennis, Jeff A.; Nugent, Kenneth

doi:10.1016/j.thromres.2019.01.011

Cited by 9 publications

(9 citation statements)

References 25 publications

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“…Ball et al examined > 17,000 adult individuals in an outpatient setting. Here, COPD was not associated with MPV but emphysema patients were more likely to have MPVs below the 10th percentile (adjusted odds ratio [OR] 1.92, 95% CI: 1.11‐3.31) 124 …”

Section: How Does Platelet Size Change In Disease?mentioning

confidence: 91%

Large and small platelets—(When) do they differ?

Handtke

Thiele

2020

Journal of Thrombosis and Haemostasis

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Platelets are most important in providing cellular hemostasis but also take part in inflammation and immune processes. Increased platelet size has been regarded as a feature describing a young and more reactive subpopulation until studies were published which questioned this concept. Moreover, changes of platelet size given by the mean platelet volume (MPV) were described for immune thrombocytopenia, cardiovascular disease, atherosclerosis, venous thromboembolism, chronic lung disease, sepsis, cancer‐associated thrombosis, autoimmune disorders, and others. This review summarizes the literature on what is known about platelets with different size and describes controversies of studies with large and small platelets putting a focus on their thrombogenicity, age, and on the association of MPV with the mentioned diseases.

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Section: How Does Platelet Size Change In Disease?mentioning

confidence: 91%

Large and small platelets—(When) do they differ?

Handtke

Thiele

2020

Journal of Thrombosis and Haemostasis

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“…Both populations we examined are of predominantly European ancestry which could limit the generalizability of the results. Some prior work such as the large NHANES study (n = 17,969) suggest that African or Hispanic populations may have higher MPV than European ancestry populations, though the absolute mean difference in NHANES was small (<0.17 femptoliters) (64). There are some limitations unique to the UK BioBank analyses.…”

Section: Limitationsmentioning

confidence: 97%

Platelet Measurements and Type 2 Diabetes: Investigations in Two Population-Based Cohorts

Rodriguez

Johnson

2020

Front. Cardiovasc. Med.

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Type 2 diabetes is a major risk factor for cardiovascular disease. Given the contribution of platelets to atherothrombosis-which in turn is a major contributor to cardiac events, there may be cause to consider platelet function in management of diabetes. Despite the large body of research concerning the role of platelets in cardiovascular complications of type 2 diabetes, evidence from population-based studies of platelet aggregation in diabetes is limited. Mean Platelet Volume (MPV), a cell trait partially associated with markers of platelet activity, is more commonly available. We investigated the association of metabolic syndrome and diabetes with platelet aggregation to three physiological agonists, ADP, collagen, and epinephrine, in the Framingham Heart Study Offspring cohort. We further examined the relationship between MPV measured with Beckman Coulter LH750 instruments and self-reported diabetes as well as MPV and diabetes medication in the UK BioBank cohort, performing the largest such analysis to date. Increased platelet aggregation associated with prevalent diabetes was observed for low concentration epinephrine (0.1 µM) alone and only in analyses of participants stratified either by male sex and/or having metabolic syndrome. Other agonists and concentrations were not significant for prevalent diabetes, or in opposite direction to the main hypothesis (i.e., they showed lower platelet aggregation associated with diabetes). After a median of 18.1 years follow-up, no platelet aggregation trait was associated with increased risk of diabetes (n = 344 cases). As expected, increased MPV was significantly associated with diabetes (β = 0.0976; P = 8.62 × 10 −33). Interestingly, sex-stratified analyses indicated the association of MPV with diabetes is markedly stronger in males (β = 0.1232; P = 1.00 × 10 −31) than females (β = 0.0514; P = 7.37 × 10 −5). Among diabetes medications increased MPV was associated with Insulin (β = 0.1341; P = 1.38 × 10 −11) and decreased MPV with both Metformin (β = 0.0763; P = 1.99 × 10 −6) as well as the sulphonylureas (β = 0.0559; P = 0.0034). Each drug showed the same direction of effect in both sexes, however, the association with MPV was nearly twice as great or more in women compared to men. In conclusion, platelet function as measured by aggregation to ADP, collagen, or epinephrine does not appear to be consistently associated with diabetes, however, MPV is robustly associated suggesting future work may focus on how MPV segments pre-diabetics and diabetics for risk prediction.

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“…1 Mean platelet volume (MPV) is a measure of platelet size and activation and has been implicated in various diseases in recent studies. 2,3 An increase in MPV has been associated with increased mortality in sepsis, which is a severe acute inflammatory state. 4 C-reactive protein (CRP), an acute-phase reactant produced by the liver, is an established marker of inflammation.…”

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confidence: 99%

Relation between mean platelet volume and C-reactive protein

Ball

Dennis

Bedanie

et al. 2020

Baylor University Medical Center Proceedings

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Mean platelet volume (MPV) is a measure of platelet activation, and C-reactive protein (CRP) is an established marker of inflammation. Studies on the correlation between MPV and CRP have produced ambiguous results. We undertook a population study with the National Health and Nutrition Examination Survey (NHANES) data (2005)(2006)(2007)(2008)(2009)(2010) to investigate the relationship between CRP and MPV. CRP was analyzed both as a continuous variable and as a categorical variable (low, intermediate, or high). Multivariate ordinary least squares regression analysis was used to predict the association. Statistical analyses were performed with Stata MP 15.1. In 16,329 participants, mean MPV was 7.9 fL (standard deviation 0.87). Overall mean CRP in the population was 0.4 mg/dL (standard deviation 0.78). In adjusted regression models with CRP as a continuous measure, individuals with high CRP had significantly lower MPV (b ¼ À0.04; standard error 0.01; 95% confidence interval À0.06 to À0.01; P ¼ 0.002). In adjusted regression models using CRP categories, participants with high CRP (>3 mg/dL) had significantly lower MPV compared with the low CRP group (b ¼ À0.20; standard error 0.09; 95% confidence interval À0.38 to À0.01; P ¼ 0.035). Our study revealed a significant inverse correlation between MPV and CRP in NHANES participants.

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Implications of mean platelet volume in health and disease: A large population study on data from National Health and Nutrition Examination Survey

Cited by 9 publications

References 25 publications

Large and small platelets—(When) do they differ?

Large and small platelets—(When) do they differ?

Platelet Measurements and Type 2 Diabetes: Investigations in Two Population-Based Cohorts

Relation between mean platelet volume and C-reactive protein

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