Implications of oxidative stress in high sucrose low magnesium diet fed rats

Chaudhary, Dharam Paul; Boparai, Ravneet K.; Bansal, Devi D.

doi:10.1007/s00394-007-0677-4

Cited by 24 publications

(14 citation statements)

References 38 publications

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“…We have previously shown that high sucrose diet given to Mg 2+ deficient rats produce type 2 diabetes like condition [1,32,33]. Increased triglyceride level is a hallmark of type 2 diabetes which is very clear from the results of this study as triglyceride levels are very high in HFHS group as compared to CD group.…”

Section: Discussionsupporting

confidence: 60%

Studies on the Development of a Non-genetic Obese Type 2 Diabetic Rat Model: Amelioration by (+)-Catechin Hydrate

Mehra¹,

Koul²,

Bansal³

2010

Am. J. Biomed. Sci.

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This study was planned to investigate the effect of pure catechin, a green tea flavonoid on the levels of fasting plasma glucose, plasma insulin, plasma and tissue lipids in high fat high sucrose diet fed rats for a period of 12 weeks. The results indicate that feeding the rats with high fat and high sucrose diet resulted into the development of an obese type 2 diabetic rat model and (+)-catechin hydrate to some extent prevented the weight gain, rise in blood glucose, cholesterol and Triglyceride levels. Insulin levels were also high in high fat high sucrose fed rats as compared to rats fed high fat, high sucrose and administered (+)-catechin hydrate. Catechin also prevented the weight gain in control group thereby limiting its role only in obesity. Catechin supplementation in rats fed high fat and high sucrose diet was also found to prevent increase in cholesterol, triglycerides and glycolipid levels in liver and cholesterol and glycolipid levels in heart. In conclusion high fat and high sucrose diet is useful in the development of an obese type 2 diabetic rat model and catechin to some extent is beneficial.

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Section: Discussionsupporting

confidence: 60%

Studies on the Development of a Non-genetic Obese Type 2 Diabetic Rat Model: Amelioration by (+)-Catechin Hydrate

Mehra¹,

Koul²,

Bansal³

2010

Am. J. Biomed. Sci.

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“…A previous study also found that ADH activity decreased with sucrose concentration in D. melanogaster larvae (McKechnie and Geer, 1984). Moreover, sucrose consumption has also been found to increase oxidative damage and decrease antioxidant defences in rats, presumably because of their higher mitochondrial metabolism, ROS production and utilization of antioxidant defences (Busserolles et al, 2002;Chaudhary et al, 2007).…”

Section: Discussion Effects Of Fruit Ripening Stage In the Absence Ofmentioning

confidence: 84%

Feeding on ripening and over-ripening fruit: interactions between sugar, ethanol and polyphenol contents in a tropical butterfly

Beaulieu

Franke

Fischer

2017

Journal of Experimental Biology

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In ripe fruit, energy mostly derives from sugar, while in over-ripe fruit, it also comes from ethanol. Such ripeness differences may alter the fitness benefits associated with frugivory if animals are unable to degrade ethanol when consuming over-ripe fruit. In the tropical butterfly Bicyclus anynana, we found that females consuming isocaloric solutions mimicking ripe (20% sucrose) and over-ripe fruit (10% sucrose, 7% ethanol) of the palm Astrocaryum standleyanum exhibited higher fecundity than females consuming a solution mimicking unripe fruit (10% sucrose). Moreover, relative to butterflies consuming a solution mimicking unripe fruit, survival was enhanced when butterflies consumed a solution mimicking either ripe fruit supplemented with polyphenols (fruit antioxidant compounds) or over-ripe fruit devoid of polyphenols. This suggests that (1) butterflies have evolved tolerance mechanisms to derive the same reproductive benefits from ethanol and sugar, and (2) polyphenols may regulate the allocation of sugar and ethanol to maintenance mechanisms. However, variation in fitness owing to the composition of feeding solutions was not paralleled by corresponding physiological changes (alcohol dehydrogenase activity, oxidative status) in butterflies. The fitness proxies and physiological parameters that we measured therefore appear to reflect distinct biological pathways. Overall, our results highlight that the energy content of fruit primarily affects the fecundity of B. anynana butterflies, while the effects of fruit consumption on survival are more complex and vary depending on ripening stage and polyphenol presence. The actual underlying physiological mechanisms linking fruit ripeness and fitness components remain to be clarified.

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“…Therefore, Mg-evoked dehydration could be a risk factor for the development and further deterioration of CDDPinduced AKI in this experimental condition. In a previous study, enhancement of CDDP-induced AKI was caused by inflammatory cytokines and oxidative stress that appeared to be evoked in response to Mg depletion [14][15][16]. Furthermore, it was reported that Mg supplementation prevented cyclosporine-induced chronic kidney injury [17].…”

Section: Discussionmentioning

confidence: 95%

Enhanced renal accumulation of cisplatin via renal organic cation transporter deteriorates acute kidney injury in hypomagnesemic rats

et al. 2009

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Implications of oxidative stress in high sucrose low magnesium diet fed rats

Abstract: These findings suggest that a diet low in magnesium and high in sucrose causes oxidative stress in rats, as reflected by increased lipid peroxidation and reduced anti-oxidant potential.

Cited by 24 publications

References 38 publications

Studies on the Development of a Non-genetic Obese Type 2 Diabetic Rat Model: Amelioration by (+)-Catechin Hydrate

Studies on the Development of a Non-genetic Obese Type 2 Diabetic Rat Model: Amelioration by (+)-Catechin Hydrate

Feeding on ripening and over-ripening fruit: interactions between sugar, ethanol and polyphenol contents in a tropical butterfly

Enhanced renal accumulation of cisplatin via renal organic cation transporter deteriorates acute kidney injury in hypomagnesemic rats

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