Importance of End‐Diastolic Rather than End‐Systolic Right Atrial Size in Chronic Pulmonary Hypertension

López‐Candales, Angel; Palm, Denada; López, Francisco Escribano; Pérez, Reynerio; Candales, Maria Dolores

doi:10.1111/echo.12968

Cited by 5 publications

(10 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, maximal excursion of the TA in systole has been identified as an excellent surrogate measure of RV systolic function in several clinical situations. 1,10,11,20,26 …”

Section: | Discussionmentioning

confidence: 99%

“…In addition, RA area was traced at the end of ventricular systole (largest volume) from the lateral aspect of the TA to the septal aspect, excluding the area between the leaflets and annulus, following the RA endocardium, excluding the IVC and superior vena cava and RA appendage. 10,11 In a similar fashion, RA measurements were also obtained at the end of ventricular diastole (smallest RA dimension) as previously described. 11 Finally, RA fractional area change was calculated in the standard method.…”

Section: | Methodsmentioning

confidence: 99%

“…10,11 In a similar fashion, RA measurements were also obtained at the end of ventricular diastole (smallest RA dimension) as previously described. 11 Finally, RA fractional area change was calculated in the standard method. 10 …”

Section: | Methodsmentioning

confidence: 99%

“…Reliability of RA measurements for this patient population has already been published. 11 All statistical analyses were performed using STATA version 14.2 StataCorp, College Station, TX, USA. P -values of less than .05 were considered to be statistically significant.…”

Section: | Methodsmentioning

confidence: 99%

“…10,11 Furthermore, visualization of the RA is limited to the four-chamber apical view during echocardiographic examination. 12 To date, this transthoracic window has been invaluable to examine longitudinal displacement of the tricuspid annulus (TA) that descends during ventricular systole while it ascends during both ventricular diastole and after atrial contraction.…”

Section: | Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Maximal systolic excursion of the tricuspid annulus is independent of right atrial size and function in chronic pulmonary hypertension

2017

View full text Add to dashboard Cite

Background Even though the tricuspid annulus (TA) is anatomically and functionally related to right atrioventricular dependence and tricuspid annular plane systolic excursion (TAPSE) is a well-known measure of right ventricular (RV) systolic function, there is paucity of data regarding the potential impact that right atrial (RA) size and function have on TAPSE. Hence, we sought to determine whether RA volumetric and longitudinal measures affect TAPSE in patients with chronic pulmonary hypertension (cPH). Methods In this retrospective study, echocardiographic data from 110 patients were reviewed and the studied population was divided into Group I consisting of 50 patients (50±11 years) without PH and Group II that included 60 patients (55±14 years) with cPH. Results Even though RA areas, RA fractional area change, and maximal long-axis length measurements were abnormal in cPH patients, TA tissue Doppler imaging systolic velocity and RV fractional area change were the only useful variables in identifying patients with abnormal TAPSE (P<.0001 and P=.018, respectively). Additionally, TAPSE was independent of all RA measures, left ventricular ejection fraction, and age (P>.05). Conclusions Based on these results, TAPSE does not appear to be influenced by either RA size or function. Additional studies using strain echocardiography to interrogate RA mechanics might now be very useful to advance our understanding of TA motion in cPH patients given recent data showing that RA function accounts for a significantly greater proportion of total right heart function in patients with cPH than in normal subjects.

show abstract

“…Therefore, maximal excursion of the TA in systole has been identified as an excellent surrogate measure of RV systolic function in several clinical situations. 1,10,11,20,26 …”

Section: | Discussionmentioning

confidence: 99%

Section: | Methodsmentioning

confidence: 99%

Section: | Methodsmentioning

confidence: 99%

Section: | Methodsmentioning

confidence: 99%

Section: | Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Maximal systolic excursion of the tricuspid annulus is independent of right atrial size and function in chronic pulmonary hypertension

2017

View full text Add to dashboard Cite

show abstract

Echocardiographic Reference Values for Right Atrial Size in Children with and without Atrial Septal Defects or Pulmonary Hypertension

et al. 2015

View full text Add to dashboard Cite

Right atrial (RA) size may become a very useful, easily obtainable, echocardiographic variable in patients with congenital heart disease (CHD) with right-heart dysfunction; however, according studies in children are lacking. We investigated growth-related changes of RA dimensions in healthy children. Moreover, we determined the predictive value of RA variables in both children with secundum atrial septal defect (ASD) and children with pulmonary hypertension (PH) secondary to CHD (PH-CHD). This is a prospective study in 516 healthy children, in 80 children with a secundum ASD (>7 mm superior-inferior dimension), and in 42 children with PH-CHD. We determined three RA variables, i.e., end-systolic major-axis length, end-systolic minor-axis length, and end-systolic area, stratified by age, body weight, length, and surface area. RA end-systolic length and area z scores were increased in children with ASD and PH-CHD when compared to those variables in the healthy control population. Using the Youden Index to determine the best cutoff scores in sex- and age-specific RA dimensions, we observed a sensitivity and specificity up to 94 and 91 %, respectively, in ASD children and 98 and 94 %, respectively, in PH-CHD children. We provide normal values (z scores -2 to +2) for RA size and area in a representative, large pediatric cohort. Enlarged RA variables with scores >+2 were predictive of secundum ASD and PH-CHD. Two-dimensional determination of RA size can identify enlarged RAs in the setting of high volume load (ASD) or pressure load (PH-CHD).

show abstract

Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives

et al. 2017

View full text Add to dashboard Cite

A series of novel thiazolidine-2,4-dione or rhodanine derivatives (, ) were synthesized and evaluated for their α-glucosidase inhibitory activity. The majority of compounds exhibited potent inhibitory activity in the range of 5.44 ± 0.13 to 50.45 ± 0.39 μM, when compared to the standard drug acarbose (IC = 817.38 ± 6.27 μM). Among the compounds in the series, compounds ,, ,, and showed potent inhibitory potential with IC values of 20.95 ± 0.21, 16.11 ± 0.19, 7.72 ± 0.16, 7.91 ± 0.17, 6.59 ± 0.15 and 5.44 ± 0.13 μM, respectively. Compound (IC = 5.44 ± 0.13 μM), containing chloro and rhodanine groups at the 2- and 4-positions of the phenyl ring respectively, was found to be the most active compound that inhibits α-glucosidase activity. Furthermore, molecular docking studies were performed to understand the binding interactions between the molecule and enzyme.

show abstract

Importance of End‐Diastolic Rather than End‐Systolic Right Atrial Size in Chronic Pulmonary Hypertension

Cited by 5 publications

References 53 publications

Maximal systolic excursion of the tricuspid annulus is independent of right atrial size and function in chronic pulmonary hypertension

Maximal systolic excursion of the tricuspid annulus is independent of right atrial size and function in chronic pulmonary hypertension

Echocardiographic Reference Values for Right Atrial Size in Children with and without Atrial Septal Defects or Pulmonary Hypertension

Synthesis, α-glucosidase inhibition and molecular docking studies of novel thiazolidine-2,4-dione or rhodanine derivatives

Contact Info

Product

Resources

About