Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production

Frecuencia de los genotipos babA2, oipA y cagE de Helicobacter pylori en pacientes colombianos con enfermedades gastroduodenales.

“…Los resultados de estos estudios sugieren que la expresión diferencial de la adhesina babA2 podría correlacionarse con las diferencias en incidencia de cáncer gástrico en diferentes regiones geográficas. Yamaoka et al reportan relación entre la presencia de babA2 y con cambos histológicos como metaplasia intestinal y atrofia (33,40); sin embargo, no logran mostrar su utilidad como marcador de riesgo de enfermedad. En conjunto, estos resultados no soportan la hipótesis de que la tipificación de babA2 aumente el poder para discriminar entre cepas cagA positivas aquellas con potencial ulcerogénico o carcinogénico en nuestra población.…”

Investigation of Association between oipA and iceA1/iceA2 Genotypes of Helicobacter pylori and Gastric Cancer in Iran

“…OipA is shown to be associated with increased secretion of interleukin 8, progression of gastric inflammation, bacterial adherence and adaptation to the host microenvironment (Yamaoka et al, 2000;2002;Dossumbekova et al, 2006), and thereby, contribute to development of gastroentric diseases. For instance, Markovska and colleagues (2011) observed that 97% of Bulgarian patients with peptic ulcers 1 and 66% of those with Gastritis were oipA positive.…”

Correlation betweenHelicobacter pyloriOipA Protein Expression andoipAGene Switch Status

“…The Helicobacter pylori outer inflammatory protein, OipA, is an important virulence factor associated with enhanced interleukin-8 secretion and increased inflammation in vitro as well as the clinically important presentation of peptic ulcer (11,13,14). Expression of OipA is regulated by the slipped-strand repair mechanism based on the number of CT dinucleotide repeats in the 5Ј region of the oipA gene (switch on ϭ functional and switch off ϭ nonfunctional) (11), such that gene switch status may affect bacterial characteristics such as virulence.…”

“…Expression of OipA is regulated by the slipped-strand repair mechanism based on the number of CT dinucleotide repeats in the 5Ј region of the oipA gene (switch on ϭ functional and switch off ϭ nonfunctional) (11), such that gene switch status may affect bacterial characteristics such as virulence. Isolates that contain the cag pathogenicity island (CagA is a marker) typically also have oipA with functional status "on" (1,3,12,13). Currently, prediction of the presence of a functional OipA protein requires PCR-based sequencing of the signal region of the gene.…”