Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats

Scheggi, Simona; Pelliccia, Teresa; Ferrari, Alberto; Montis, Maria Graziella De; Gambarana, Carla

doi:10.1016/j.neuroscience.2015.02.006

Cited by 24 publications

(30 citation statements)

References 32 publications

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“…In this trial, the researchers have also studied the effect of other drugs, understanding that while clozapine and lithium showed an antianhedonic effect, haloperidol did not equivalently. Such findings confirm that dopaminergic dysfunction has a relevant role in anhedonia; drugs that interact with the dopaminergic system could be utilized to treat anhedonia and therefore the underlying mental illness …”

Section: Introductionsupporting

confidence: 54%

“…Such findings confirm that dopaminergic dysfunction has a relevant role in anhedonia; drugs that interact with the dopaminergic system could be utilized to treat anhedonia and therefore the underlying mental illness. 52 Finally, a recent systematic review by Cao and colleagues 53 analyzed 17 studies on MDD patients with anhedonic features treated with 14 different antidepressants. This review suggested that antidepressants improve anhedonic symptoms, yet no significant difference was found among subjects.…”

Section: Anhedonia and Pharmacological Treatments: Outcome Measure mentioning

confidence: 99%

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Anhedonia across borders: Transdiagnostic relevance of reward dysfunction for noninvasive brain stimulation endophenotypes

et al. 2019

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Introduction Anhedonia is a transdiagnostic psychopathological dimension, consisting in the impaired ability to experience pleasure. In order to further our understanding of its neural correlates and to explore its potential relevance as a predictor of treatment response, in this article we systematically reviewed studies involving anhedonia and neuromodulation interventions, across different disorders. Methods We included seven studies fulfilling inclusion/exclusion criteria and involving different measures of anticipatory and consummatory anhedonia, as well as different noninvasive brain stimulation interventions (transcranial magnetic stimulation and transcranial direct current stimulation). Studies not exploring hedonic measures or not involving neuromodulation intervention were excluded. Results All the included studies entailed the use of rTMS protocols in one of the diverse prefrontal targets. The limited amount of studies and the heterogeneity of stimulation protocols did not allow to draw any conclusion with regard to the efficacy of rTMS in the treatment of transnosographic anhedonia. A potential for anhedonia in dissecting possible endophenotypes of different psychopathological conditions preliminarily emerged. Conclusions Anhedonia is an underexplored condition in neuromodulation trials. It may represent a valuable transdiagnostic dimension that requires further examination in order to discover new clinical predictors for treatment response.

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Section: Introductionsupporting

confidence: 54%

Section: Anhedonia and Pharmacological Treatments: Outcome Measure mentioning

confidence: 99%

Anhedonia across borders: Transdiagnostic relevance of reward dysfunction for noninvasive brain stimulation endophenotypes

et al. 2019

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“…For example, depressed smokers show greater PRT motivation to obtain nicotine than money (Audrain-McGovern et al, 2014) and recreational drinkers show increased PRT motivation for alcohol following depressed mood induction (Willner et al, 1998b). A strength of the PRT is its applicability in both animal models and humans, making this task especially useful for translational investigation (Scheggi et al, 2015; Willner et al, 1998a). …”

Section: Introductionmentioning

confidence: 99%

Diminished effort on a progressive ratio task in both unipolar and bipolar depression

Hershenberg

Satterthwaite

Daldal

et al. 2016

Journal of Affective Disorders

132

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Background Amotivation, or decisional anhedonia, is a prominent and disabling feature of depression. However, this aspect of depression remains understudied, and no prior work has applied objective laboratory tests of motivation in both unipolar and bipolar depression. Methods We assessed motivation deficits using a Progressive Ratio Task (PRT) that indexes willingness to exert effort for monetary reward. The PRT was administered to 96 adults ages 18–60 including 25 participants with a current episode of unipolar depression, 28 with bipolar disorder (current episode depressed), and 43 controls without any lifetime history of Axis I psychiatric disorders. Results Depressed participants exhibited significantly lower motivation than control participants as objectively defined by progressive ratio breakpoints. Both the unipolar and bipolar groups were lower than controls but did not differ from each other. Limitations Medication use differed across groups, and we did not have a separate control task to measure psychomotor activity; however neither medication effects or psychomotor slowing are likely to explain our findings. Conclusions Our study fills an important gap in the literature by providing evidence that diminished effort on the PRT is present across depressed patients who experience either unipolar or bipolar depression. This adds to growing evidence for shared mechanisms of reward and motivation dysfunction, and highlights the importance of improving the assessment and treatment of motivation deficits across the mood disorders spectrum.

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“…observed with the acute ED test will be further characterized using validated models of depressive symptoms (Gambarana et al 2001a;Marchese et al 2013;Scheggi et al 2015).…”

Section: Discussionmentioning

confidence: 99%

The protective effect of Hypericum connatum on stress-induced escape deficit in rat is related to its flavonoid content

Scheggi

Marandino

Monte

et al. 2016

Pharmaceutical Biology

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De Feo (2016) The protective effect of Hypericumconnatum on stress-induced escape deficit in rat is related to its flavonoid content, Pharmaceutical Biology, 54:9, 1782-1792, DOI: 10.3109/13880209.2015 Objective This study evaluates the antidepressant-like effect of H. connatum in rats and identifies the components involved in this activity. Materials and methods First, the effects of acute and 14-d oral administrations of an extract derived from H. connatum aerial parts were studied using the Escape Deficit (ED) test. Next, methanol-extracted flavonoid-enriched fractions B and C and fraction-purified flavonoids (quercetin, rutin and isoquercitrin) were evaluated in the ED test after acute administration. To rule out possible confounding effects of the flavonoids, we examined nociceptive threshold using the tailflick test and anxious behaviour using the elevated plus maze (EPM) test. Results Hypericum connatum increased reactivity of unavoidable stress-exposed rats after acute

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Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats

Cited by 24 publications

References 32 publications

Anhedonia across borders: Transdiagnostic relevance of reward dysfunction for noninvasive brain stimulation endophenotypes

Anhedonia across borders: Transdiagnostic relevance of reward dysfunction for noninvasive brain stimulation endophenotypes

Diminished effort on a progressive ratio task in both unipolar and bipolar depression

The protective effect of Hypericum connatum on stress-induced escape deficit in rat is related to its flavonoid content

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