Imprinted soft contact lenses as norfloxacin delivery systems

Alvarez‐Lorenzo, Carmen; Yáñez, Fernando; Barreiro-Iglesias, Rafael; Concheiro, Ángel

doi:10.1016/j.jconrel.2006.05.003

Cited by 236 publications

(134 citation statements)

References 39 publications

Supporting

Mentioning

126

Contrasting

Unclassified

Order By: Relevance

“…In fact, the low solubility of some drugs, the small volumes of release (e.g. 2-10 mL) and experiments performed without stirring often used in this type of experiments, may compromise the infinite sink conditions [18,19]. It should be stressed that in the eye, sink conditions can be maintained if the drug clearance is high.…”

Section: Introductionmentioning

confidence: 99%

Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling

Pimenta

Valente

Pereira

et al. 2016

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

Currently, most in vitro drug release studies for ophthalmic applications are carried out in static sink conditions. Although this procedure is simple and useful to make comparative studies, it does not describe adequately the drug release kinetics in the eye, considering the small tear volume and flow rates found in vivo.In this work a microfluidic cell was designed and used to mimic the continuous, In conclusion, the use of the microfluidic cell in conjunction with the numerical model shall be a valuable tool to design and optimize new therapeutic drug loaded SCLs.

show abstract

Section: Introductionmentioning

confidence: 99%

Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling

Pimenta

Valente

Pereira

et al. 2016

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

show abstract

“…In most recent studies, MIPs with artificially fabricated receptor structures have been used to develop the design of drug delivery systems (DDS) [16][17][18][19][20][21]. Molecular imprinting technology can provide polymeric materials with the ability to recognize specific bioactive molecules with sorption and release behavior that can be made sensitive to properties of the surrounding medium.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of molecularly imprinted polymer for controlled release of tramadol

2010

View full text Add to dashboard Cite

Abstract:In this paper, we describe how to prepare a highly selective imprinted polymer by a bulk polymerization technique. We used tramadol as the template, (MAA) as functional monomers, and (EGDMA) as the cross-linker in chloroform as solvent. Results from Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Scanning Electron microscopy (SEM) show that this imprinted sorbent exhibits good recognition and high affinity for tramadol. Selectivity of molecularly imprinted polympers (MIP) was evaluated by comparing several substances with similar molecular structures to that of tramadol. Controlled release of tramadol from MIPs was investigated through in vitro dissolution tests and by measuring the absorbance at λ max of 272 nm by (HPLC-UV). The dissolution media employed were hydrochloric acid pH 3.0 and phosphate buffers, pH 5.0 and 7.4, maintained at 37 and 25 ± 0.5°C. The results show the ability of MIP polymers to control tramadol release. In all cases, the release of MIPs was deferred for a longer time as compared to NMIP. At a pH of 7.4 and 25˚C slower release of tramadol imprinted polymer occurred.

show abstract

“…In the later study, the groups of Hiratani and Alvarez-Lorenzo investigated the effects of different monomers in order to improve their capacity. They also evaluated the impact of the stoichiometry of reagents and polymerization conditions Hiratani et al, 2005a,b) and the imprinted soft contact lenses were also investigated for norfloxacin delivery systems by the same group (Alvarez-Lorenzo et al, 2006).…”

Section: Mips In Ocular Therapeutic Applicationsmentioning

confidence: 99%

Molecular imprinted polymers as drug delivery vehicles

Zaidi

2014

Drug Delivery

111

View full text Add to dashboard Cite

This review is aimed to discuss the molecular imprinted polymer (MIP)-based drug delivery systems (DDS). Molecular imprinted polymers have proved to possess the potential and also as a suitable material in several areas over a long period of time. However, only recently it has been employed for pharmaceuticals and biomedical applications, particularly as drug delivery vehicles due to properties including selective recognition generated from imprinting the desired analyte, favorable in harsh experimental conditions, and feedback-controlled recognitive drug release. Hence, this review will discuss their synthesis, the reason they are selected as drug delivery vehicles and for their applications in several drug administration routes (i.e. transdermal, ocular and gastrointestinal or stimuli-reactive routes).

show abstract

Imprinted soft contact lenses as norfloxacin delivery systems

Cited by 236 publications

References 39 publications

Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling

Simulation of the hydrodynamic conditions of the eye to better reproduce the drug release from hydrogel contact lenses: experiments and modeling

Synthesis and characterization of molecularly imprinted polymer for controlled release of tramadol

Molecular imprinted polymers as drug delivery vehicles

Contact Info

Product

Resources

About