Improved harmonic phase myocardial strain maps

Kuijer, Joost P.A.; Jansen, E.J.; Marcus, J. Tim; Rossum, Albert C. van; Heethaar, R.M.

doi:10.1002/mrm.1286

Cited by 58 publications

(53 citation statements)

References 19 publications

(24 reference statements)

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“…In a number of previous studies it was argued that velocity encoding is more suitable for determining regional contractility of the mouse heart than MRI tagging, because of superior resolution and the possibility to measure three-dimensional displacements [10,[31][32][33][34]. However, in this paper we demonstrate that the use of MRI tagging based on the CSPAMM technique, in combination with the harmonic phase (HARP) analysis method [35,36], yields accurate information on regional mouse cardiac function with the same spatial resolution as the parent magnitude images.…”

Section: Introductionmentioning

confidence: 65%

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Magnetic resonance imaging of regional cardiac function in the mouse

Heijman

Strijkers

Habets

et al. 2004

MAGMA

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In this paper we introduce an improved harmonic phase (HARP) analysis for complementary spatial modulation of magnetization (CSPAMM) tagging of the mouse left ventricular wall, which enables the determination of regional displacement fields with the same resolution as the corresponding CINE anatomical images. CINE MRI was used to measure global function, such as the ejection fraction. The method was tested on two healthy mouse hearts and two mouse hearts with a myocardial infarction, which was induced by a ligation of the left anterior descending coronary artery. We show that the regional displacement fields can be determined. The mean circumferential strain for the left ventricular wall of one of the healthy mice was −0.09 ± 0.04 (mean ± standard deviation), while for one of the infarcted mouse hearts strains of −0.02 ± 0.02 and −0.10 ± 0.03 were found in the infarcted and remote regions, respectively.

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Section: Introductionmentioning

confidence: 65%

“…A major advantage of the CSPAMM technique is that the zero-order image information in k-space is filtered away efficiently and automatically. This will lead to a lower error in the strain and fewer artifacts [36].…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging of regional cardiac function in the mouse

Heijman

Strijkers

Habets

et al. 2004

MAGMA

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“…Complementary acquisition and subtraction of inverted tagged images (C-SPAMM) has been recommended for HARP strain analysis (Kuijer et al, 2001) but C-SPAMM would require undesirable additional impacts.…”

Section: Number Of Impactsmentioning

confidence: 99%

“…The HARP method allows automated strain estimation and facilitates rapid image acquisition, because only data from a limited set of spatial frequencies (a limited section of k-space) is needed. Kuijer et al (2001), Kraitchman et al (2003), and Sampath et al (2003) among others have extended the original technique. Validation of HARP strain analysis has been performed by Liu et al (2004) and Bayly et al (2004).…”

Section: Introductionmentioning

confidence: 99%

In vivo imaging of rapid deformation and strain in an animal model of traumatic brain injury

Bayly

Black

Pedersen

et al. 2006

Journal of Biomechanics

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In traumatic brain injury (TBI) rapid deformation of brain tissue leads to axonal injury and cell death. In vivo quantification of such fast deformations is extremely difficult, but important for understanding the mechanisms of degeneration post-trauma and for development of numerical models of injury biomechanics. In this paper, strain fields in the brain of the perinatal rat were estimated from data obtained in vivo during rapid indentation. Tagged magnetic resonance (MR) images were obtained with high spatial (0.2 mm) and temporal (3.9 ms) resolution by gated image acquisition during and after impact. Impacts were repeated either 64 or 128 times to obtain images of horizontal and vertical tag lines in coronal and sagittal planes. Strain fields were estimated by harmonic phase (HARP) analysis of the tagged images. The original MR data was filtered and Fourier-transformed to obtain HARP images, following a method originally developed by Osman et al. (IEEE Trans. Med. Imaging 19(3) (2000) 186). The displacements of material points were estimated from intersections of HARP contours and used to generate estimates of the deformation gradient and Lagrangian strain tensors. Maximum principal Lagrangian strains of >0.20 at strain rates >40/s were observed during indentations of 2 mm depth and 21 ms duration.

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“…The importance and impact of anesthesia for image-based phenotyping in patho-physiological status is addressed with brief references to the possible mechanisms and cellular and sub-cellular target sites of anesthesia action. The section is complemented with recent findings on heart rate variability (as a result of the widely used inhalational anesthesia use) under optimal anesthesia conditions using isoflurane and long term physiological stability elicited from the use of the balancing anesthetic, Nitrous Oxide.A historical overview of the evolution of mouse cardiac MRI is also attempted (in direct correlation with the evolution and progress of human clinical cardiac MRI, radiofrequency [Osman 1999, Kuijer 2001, tagging and advanced imaging techniques. MRI-based, accurate threedimensional (3D) and 4D surface and finite element mesh model extractions, in association with advanced segmentation -seed-based or semi-automatic -and registration techniquesdiffeomorphic or landmark-based, are shown to facilitate efficient mouse inter-strain cardiac hemodynamical comparisons of both right and left-ventricular chambers.…”

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confidence: 99%

Study of the Murine Cardiac Mechanical Function Using Magnetic Resonance Imaging: The Current Status, Challenges, and Future Perspectives

Constantinides¹

2013

Practical Applications in Biomedical Engineering

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Despite the existence of a plethora of cardiac functional techniques for characterization of mechanical structure, function and dysfunction, a parallel need exists for development of invasive and non-invasive tools and techniques to describe the left ventricular (LV) tissue material properties as these relate to the: (a) mechanical pumping function of the LV; (b) myocardial oxygen demand defining myocyte metabolic status; (c) coronary blood flow and its auto-regulation; (d) arhythmogenic risk; (e) cell-signaling pathways responsible for growth and remodeling during development and disease. Reinforcing basic physiology work, invasive catheterization experiments ] have also allowed determination of inotropic and lusitropic cardiac status, while Magnetic Resonance Imaging (MRI) experimentation, methodologies and technology advances have facilitated migration of such work to a non-invasive imaging platform, with tremendous potential for future basic science and translational research.Specifically, advances in MRI techniques (myocardial spin tagging [Zerhouni 1988, Axel 1989, DENSE [Aletras 1999], and harmonic phase imaging [Osman 1999]) have been introduced over the last decades to quantify cardiac function, allowing myocardial tracking, motion and strain quantification in normal and genetically engineered mice [Rockman 1991, Franco 1999, Brede 2001, Engel 2004, Wilding 2005. Critical to such work has been the validation of the underlying hypothesis of morphological and functional scaling from mouse to human (through consideration of global cardiac function, circulatory control, blood flow distribution, Ca 2+ storage and cycling, myosin light chain distribution, and force frequency reserve), for comparative studies.This chapter provides an overview of the major physiological issues and challenges for mouse MR imaging and discusses the most recent and major advances in conventional and new cardiac Magnetic Resonance imaging strategies, that ultimately allow quantification of motion, global, and regional cardiac function, strain, and elasticity, characterizing inotropic and lusitropic contractile function and dysfunction in humans and transgenic mice for image-based phenotyping.Specifically, this chapter attempts a detailed reference to the mouse as a research model, focusing on its genetic background and homology with the human genome and to the developmental and morphological differences between mouse and man, thus addressing cellular and global organ similarities and differences. As a basic determinant of structure, cardiac functional differences are associated, justified by carefully-controlled indices that determine integrative physiological control and functional activities, including metabolism, perfusion, angiogenetic, collateral flow, and coronary reserve. The importance and impact of anesthesia for image-based phenotyping in patho-physiological status is addressed with brief references to the possible mechanisms and cellular and sub-cellular target sites of anesthesia action. The section is complemented with...

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Improved harmonic phase myocardial strain maps

Cited by 58 publications

References 19 publications

Magnetic resonance imaging of regional cardiac function in the mouse

Magnetic resonance imaging of regional cardiac function in the mouse

In vivo imaging of rapid deformation and strain in an animal model of traumatic brain injury

Study of the Murine Cardiac Mechanical Function Using Magnetic Resonance Imaging: The Current Status, Challenges, and Future Perspectives

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