Improvement in biocompatibility of ZrO2–Al2O3 nano-composite by addition of HA

Kong, Young‐Min; Bae, Chang‐Jun; Lee, Su-Hee; Kim, Hae‐Won; Kim, Hyoun‐Ee

doi:10.1016/j.biomaterials.2004.02.061

Cited by 126 publications

(60 citation statements)

References 16 publications

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“…5,6 An earlier report explored ZrO2-SiO2 binary oxides as a ceramic-glass composite for hard tissue biomaterial applications. 7 This system shows two important features: the preservation of a mechanically stable t-ZrO2 phase coexisting with amorphous SiO2 8 and the presence of glassy SiO2 in the range of 40-60 wt.…”

Section: Introductionmentioning

confidence: 99%

Tetragonal to Cubic Transformation of SiO₂-Stabilized ZrO₂ Polymorph through Dysprosium Substitutions

2017

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Partially stabilized tetragonal zirconia (t-ZrO2) is of particular interest for hard tissue replacements. Ageing related failures of the ceramic associated with the gradual transformation from t-ZrO2 to m-ZrO2 (monoclinic zirconia) can lead to its premature removal from the implant site. In addition, monitoring the satisfactory performance of the implant throughout its life span without invasive techniques is a challenging task. The magnetic resonance imaging (MRI) contrast ability of dysprosium (Dy 3+ ) is well established. To this aim, varied levels of Dy 3+ additions in the ZrO2-SiO2 binary oxide system have been explored. The results indicate the effective role of Dy 3+ in the formation of thermally and mechanically stable c-ZrO2 (cubic zirconia) phase at higher temperatures. The presence of SiO2 influenced the t-ZrO2 stabilization whereas Dy 3+ tends to occupy the ZrO2 lattice sites to induce c-ZrO2 transition. Magnetic and magnetic resonance imaging (MRI) tests displayed the commendable contrast ability of Dy 3+ stabilized ZrO2-SiO2 binary systems. Nanoindentation results demonstrate a remarkable enhancement on the mechanical properties.Keywords: Silica; Zirconia; Dysprosium; Stabilization; Mechanical. 3 IntroductionThe demand for bone implants is growing rapidly due to the increasing incidents of trauma and age related defects caused by osteoporosis. In view of the above potential advantages of Dy 3+ as an addition to ZrO2-SiO2 binary oxides in terms of increased t-ZrO2 stability and enhance MRI image contrast, we present a study of the influence of Dy 3+ on the ZrO2-SiO2 binary oxide system through in-situ sol-gel synthesis, followed by a systematic analysis of the resulting phase composition and structure, mechanical strength and imaging contrast features. Materials and Methods Powder synthesisThe synthesis of Dy 3+ doped ZrO2-SiO2 (DZS) binary oxides was achieved through the sol-gel method. Analytical grade Dy(NO3)3.H2O, ZrOCl2·8H2O and (C2H5)4OSi (TEOS), all procured from Sigma-Aldrich, India, were taken as precursors for the synthesis. The molar concentrations of ZrOCl2·8H2O and (C2H5)4OSi were maintained at a constant ratio of 1: 1 throughout the 5 synthesis whereas the Dy(NO3)3 additions were adjusted to obtain a wide range of compositions.Additionally, a pure ZrO2-SiO2 binary with 1:1 molar ratio was prepared for comparative purposes. The molar concentrations of the different precursors and the respective sample codes are reported in Table 1; the same codes will be used throughout the manuscript. The synthetic procedure is briefly explained as follows. Previously prepared Dy(NO3)3 stock solution as detailed in Table 1 was added to the ZrOCl2 solution under vigorous stirring. The required amount of ethanol was added to this continuously stirred mixture at an operating temperature of 80 °C for 30 minutes. This was followed by the addition of 1 M TEOS to the solution under constant stirring conditions and finally 0.1 M of HNO3 was added to this mixture as a catalyst. The homogeneous solut...

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Section: Introductionmentioning

confidence: 99%

Tetragonal to Cubic Transformation of SiO₂-Stabilized ZrO₂ Polymorph through Dysprosium Substitutions

2017

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“…Another group comprises ceramic compounds based on the aforementioned resorbable ceramics, such as HAp, tricalcium phosphate, silica, montmorillonite, bioglass (Bioglass®) and corundum ceramics. Materials of this type are used in dentistry, maxillofacial surgery and orthopaedics [22,23]. Another area of medical applications of nanotechnology consists of studies concerning nanometric surface modification, which is an important aspect in the interaction of the surfaces of implants with live cells [24,25].…”

Section: Methods Of Obtaining and Characterising The Spinning Solutionmentioning

confidence: 99%

Fabrication of Plga/Hap and Plga/Phb/Hap Fibrous Nanocomposite Materials for Osseous Tissue Regeneration

Krucińska

Chrzanowska

Boguń

et al. 2014

Autex Research Journal

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The study presents the manufacturing of nanofibrous structures as osteoconductive, osteoinductive materials for osseous tissue regeneration. The fibrous structures were obtained by electrospinning of poly(l-lactide-coglicolide) (PLGA) with addition of hydroxyapatite (HAp) and of a blend of PLGA with polyhydroxybutyrate with HAp added. The polymers used in the experiment were synthesised by an innovative method with a zirconium catalyst. First, the optimal electrospinning process parameters were selected. For the characterisation of the obtained osseous tissue reconstruction materials, the physical, macroscopic, functional, mechanical and thermal properties as well as crystallinity index were studied. The study of the radiation sterilisation influence on average molar mass, thermal and mechanical properties was made in order to analyse the degradation effect.

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“…In this study, a modified Pechini method was used to prepare alumina, zirconia and alumina-zirconia mixed oxides. Zirconia toughened alumina is generally employed in ceramic application because of its well-known mechanical property, moreover, recently mixed oxide of zirconia and alumina has been introduced in medical application as a biocompatible nano-composite [16]. In catalytic reaction, zirconia alumina has been used as catalyst and/or support because of its surface property, stability and mechanical property.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and Catalytic Properties of Alumina–Zirconia Mixed Oxides Prepared by a Modified Pechini Method

et al. 2005

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A modified Pechini method was used to prepare alumina-zirconia mixed oxides at three different molar ratios. For comparison, pure alumina and pure zirconia were prepared using the same method. The mixed oxides were characterised by the BET method for surface area, X-ray diffraction, CO 2 and NH 3 temperature-programmed desorption. Elimination of 2-propanol was used as a probe reaction to characterise the surface of the mixed oxides. The modified Pechini preparation resulted in a poor acid-base strength of alumina surface resulting in high acetone selectivity where imperfect crystal structure of the tetragonal zirconia favoured high propylene production in 2-propanol elimination at 200°C.

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Improvement in biocompatibility of ZrO2–Al2O3 nano-composite by addition of HA

Cited by 126 publications

References 16 publications

Tetragonal to Cubic Transformation of SiO₂-Stabilized ZrO₂ Polymorph through Dysprosium Substitutions

Tetragonal to Cubic Transformation of SiO₂-Stabilized ZrO₂ Polymorph through Dysprosium Substitutions

Fabrication of Plga/Hap and Plga/Phb/Hap Fibrous Nanocomposite Materials for Osseous Tissue Regeneration

Characteristics and Catalytic Properties of Alumina–Zirconia Mixed Oxides Prepared by a Modified Pechini Method

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Improvement in biocompatibility of ZrO2–Al2O3 nano-composite by addition of HA

Cited by 126 publications

References 16 publications

Tetragonal to Cubic Transformation of SiO2-Stabilized ZrO2 Polymorph through Dysprosium Substitutions

Tetragonal to Cubic Transformation of SiO2-Stabilized ZrO2 Polymorph through Dysprosium Substitutions

Fabrication of Plga/Hap and Plga/Phb/Hap Fibrous Nanocomposite Materials for Osseous Tissue Regeneration

Characteristics and Catalytic Properties of Alumina–Zirconia Mixed Oxides Prepared by a Modified Pechini Method

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Tetragonal to Cubic Transformation of SiO₂-Stabilized ZrO₂ Polymorph through Dysprosium Substitutions

Tetragonal to Cubic Transformation of SiO₂-Stabilized ZrO₂ Polymorph through Dysprosium Substitutions