Improvement in efficacy of chemoradiotherapy by addition of an antiangiogenic agent in a murine tumor model

McDonnell, Ciarán; Holden, George W.; Sheridan, M.E; Foley, Deirdre; Moriarty, M.; Walsh, T. N.; Bouchier‐Hayes, David

doi:10.1016/j.jss.2003.09.014

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…Some authors indicated that genistein in combination with other agents could delay tumor growth by its antiangiogenic activity. 34,35) Yan et al . reported that genistein could enhance the radiosensitivity of DU145 prostate cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Genistein Stimulates Hematopoiesis and Increases Survival in Irradiated Mice

Zhou

2005

JRR

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Radiation protection from death and stimulating hematopoietic recovery by oral administrations of genistein, 160 mg/kg b.w., once daily for seven consecutive days before whole-body gamma-rays irradiation, were confirmed by tests with adult male BALB/c mice. Moreover, the protective action of genistein was compared to that of diethylstilbestrol (DES). Based on the studies of survival, behavior of hematograms, endogenous hematopoietic spleen colony formation (endoCFUs), and numbers of nucleated cell, granulocyte-macrophage colony forming units (CFU-GM) in bone marrow following irradiation, it was demonstrated that genistein was an effective radioprotector. The survival of irradiated mice protected by genistein was significantly increased and statistically higher than that of mice pre-treated with DES. Stimulated recovery of leukocytes, erythrocytes, lymphocytes and thrombocytes were observed in mice pre-treated with genistein or DES, however, the effects of genistein on promoting recovery of bone marrow nucleated cells, leukocytes and lymphocytes were significantly higher than those of DES. Enhanced endoCFUs, numbers of bone marrow nucleated cells and CFU-GM were also found in mice pre-treated with genistein as well as DES. Meanwhile, endoCFU numbers in mice pre-treated with genistein was 3.47-fold higher than that in the irradiated control group, although no significant difference was found between genistein administration and DES administration. It could be deduced that the radioprotective action against death is induced by a possible process of enhanced regeneration of the hematopoietic stem cells due to not only strengthened radioresistance and increased numbers of remained hematopoietic cells, but also enhanced post-irradiation repair or promoted proliferation of the hematopoietic stem cells. These effects of genistein may have some therapeutic implications for radiation-induced injuries.

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Section: Discussionmentioning

confidence: 99%

Genistein Stimulates Hematopoiesis and Increases Survival in Irradiated Mice

Zhou

2005

JRR

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“…In prostate cancer cells, genistein significantly inhibited DNA synthesis, cell growth, and colony formation and potentiated the effect of low doses of photon (200-300 cGy) or neutron (100-150 cGy) radiation, the latter effect being more pronounced with the combined treatment than with genistein or radiation alone (65). In an in vivo murine lung cancer model, chemoradiotherapy plus genistein resulted in significantly lower tumor volume, microvessel density, and vascular endothelial growth factor level than did chemoradiotherapy alone (111). In human esophageal cancer cell lines, genistein greatly enhanced radiosensitivity by suppressing radiation-induced activation of the survival signals Akt and p42/p44 extracellular signal-regulated protein kinase (4).…”

Section: Genisteinmentioning

confidence: 99%

Chemosensitization and Radiosensitization of Tumors by Plant Polyphenols

Garg

Buchholz

Aggarwal

2005

Antioxidants & Redox Signaling

249

153

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The treatment of cancer with chemotherapeutic agents and radiation has two major problems: time-dependent development of tumor resistance to therapy (chemoresistance and radioresistance) and nonspecific toxicity toward normal cells. Many plant-derived polyphenols have been studied intently for their potential chemopreventive properties and are pharmacologically safe. These compounds include genistein, curcumin, resveratrol, silymarin, caffeic acid phenethyl ester, flavopiridol, emodin, green tea polyphenols, piperine, oleandrin, ursolic acid, and betulinic acid. Recent research has suggested that these plant polyphenols might be used to sensitize tumor cells to chemotherapeutic agents and radiation therapy by inhibiting pathways that lead to treatment resistance. These agents have also been found to be protective from therapy-associated toxicities. How these polyphenols protect normal cells and sensitize tumor cells to treatment is discussed in this review.

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“…The incidence of liver metastases in colorectal cancer is approximately 50% and is the major cause of mortality in these patients 1 For focal hepatic metastases, the main form of treatment includes surgical resection and local ablative techniques. [2][3][4] Systemic chemotherapy is predominantly used to treat diffuse disease. Its efficacy, however, is often limited by lack of specificity with associated severe side-effects.…”

Section: Introductionmentioning

confidence: 99%