Improvement in HDL cholesterol in postmenopausal women supplemented with pumpkin seed oil: pilot study

Gossell‐Williams, Maxine; Hyde, Craig; Hunter, Tiffany; Simms-Stewart, Donnette; Fletcher, Horace; McGrowder, Donovan; Walters, Christine

doi:10.3109/13697137.2011.563882

Cited by 36 publications

(20 citation statements)

References 33 publications

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“…Replacement of a part of the cocoa butter by pumpkin seed oil markedly diminished the induction of circulating risk factors (cholesterol, triglycerides, SAA, sVCAM-1), which is in line with the short-term effects of other pumpkin seed oil preparations tested in humans and animals [ 12 , 14 , 15 ]. As these studies employed different pumpkin seed oil preparations at different doses and treatment regimens (in capsules or by oral gavage, as an addition to the regular diet), they provide evidence for a general health benefit of pumpkin seed oil, independent of how it is prepared and administered (i.e.…”

Section: Discussionsupporting

confidence: 65%

Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil

et al. 2015

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Background and AimsAs dietary saturated fatty acids are associated with metabolic and cardiovascular disease, a potentially interesting strategy to reduce disease risk is modification of the quality of fat consumed. Vegetable oils represent an attractive target for intervention, as they largely determine the intake of dietary fats. Furthermore, besides potential health effects conferred by the type of fatty acids in a vegetable oil, other minor components (e.g. phytochemicals) may also have health benefits. Here, we investigated the potential long-term health effects of isocaloric substitution of dietary fat (i.e. partial replacement of saturated by unsaturated fats), as well as putative additional effects of phytochemicals present in unrefined (virgin) oil on development of non-alcoholic fatty liver disease (NAFLD) and associated atherosclerosis. For this, we used pumpkin seed oil, because it is high in unsaturated fatty acids and a rich source of phytochemicals.MethodsApoE*3Leiden mice were fed a Western-type diet (CON) containing cocoa butter (15% w/w) and cholesterol (1% w/w) for 20 weeks to induce risk factors and disease endpoints. In separate groups, cocoa butter was replaced by refined (REF) or virgin (VIR) pumpkin seed oil (comparable in fatty acid composition, but different in phytochemical content).ResultsBoth oils improved dyslipidaemia, with decreased (V)LDL-cholesterol and triglyceride levels in comparison with CON, and additional cholesterol-lowering effects of VIR over REF. While REF did not affect plasma inflammatory markers, VIR reduced circulating serum amyloid A and soluble vascular adhesion molecule-1. NAFLD and atherosclerosis development was modestly reduced in REF, and VIR strongly decreased liver steatosis and inflammation as well as atherosclerotic lesion area and severity.ConclusionsOverall, we show that an isocaloric switch from a diet rich in saturated fat to a diet rich in unsaturated fat can attenuate NAFLD and atherosclerosis development. Phytochemical-rich virgin pumpkin seed oil exerts additional anti-inflammatory effects resulting in more pronounced health effects.

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Section: Discussionsupporting

confidence: 65%

Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil

et al. 2015

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“…These results are in agreement with previous study, which showed that TC, TGs, HDL-c, and LDL-c were higher in PSO fed rats (Makni et al, 2008; Gossell-Williams et al, 2011). A significant increase was observed by the supplementation of oxidized pumpkin seed oil, and its effects were minimized by co-administration.…”

Section: Discussionsupporting

confidence: 93%

“…A significant increase was observed by the supplementation of oxidized pumpkin seed oil, and its effects were minimized by co-administration. In humans, HDL-c levels were improved by supplementation of PSO (Gossell-Williams et al, 2011). This suggests that PSO is beneficial for improving the lipid profile against several stresses such as oxidative stress produced by oxidized lipids.…”

Section: Discussionmentioning

confidence: 99%

Changes in Acylglycerols Composition, Quality Characteristics and In vivo Effects of Dietary Pumpkin Seed Oil upon Thermal Oxidation

Zeb

Ahmad

2017

Front. Chem.

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This study was aimed to determine the acylglycerols composition, quality characteristics, and protective role of dietary pumpkin seed oil (PSO) in rabbits. PSO was thermally oxidized and analyzed for quality characteristics and acylglycerols composition using reversed phase high performance liquid chromatography with diode array detection (HPLC-DAD). Oxidized and un-oxidized oil samples were fed to the rabbits in different doses for 2 weeks. The changes in the serum biochemistry, hematology, and liver histology were studied. The levels of quality parameters such peroxide value (PV), anisidine value (AV), total phenolic contents (TPC), thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and conjugated trienes (CT) significantly increased with thermal treatment. HPLC analyses revealed 10 individual triacylglycerols (TAGs), total di-acylglycerols (DAGs), mono-acylglycerols (MAGs), and total oxidized TAGs. Trilinolein (LLL), 1-oleoyl-2,3-dilinolinoyl glycerol (OLL), triolein (OOO) and 1,2-distearoyl-3-palmitoyl glycerol (SSP) were present in higher amounts and decreased with thermal treatment. Animal's studies showed that oxidized oils decreased the whole body weight, which was ameliorated by the co-administration of un-oxidized oils. The levels of serum biochemical parameters were improved by co-administration of pumpkin seed oils. There were no significant effects of both oxidized and un-oxidized PSO on the hematological and histological parameters of rabbits. In conclusion, nutritionally important triacylglycerols were present in PSO with protective role against the toxicity of its corresponding oxidized oils.

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“…Pumpkin is a monoecious plant, which produces nectar from its actinomorphic flowers [ 1 ]. Several therapeutic activities like antioxidant [ 2 ], hepatoprotective [ 3 ], hypolipidaemic [ 3 ], antidiabetic [ 4 ], wound healing [ 5 ], anti-inflammatory [ 6 ], antibacterial [ 7 ], suppressing stimulated mononuclear cells [ 8 ], antihypertensive [ 9 ], antiarthritis [ 10 ], antidepressant activity [ 11 ], anticancer [ 12 ], antihyperlipidaemic [ 13 ], and anticataract [ 14 ] have been reported. Interestingly, the seeds of pumpkin have been reported to show cytotoxic activity in specific cancer cell lines in vitro [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

An Appraisal of Pumpkin Seed Extract in 1, 2-Dimethylhydrazine Induced Colon Cancer in Wistar Rats

Chari

Polu

Shenoy

2018

Journal of Toxicology

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Background Cancer is one of the most important public health burdens in developed and developing countries. Colon cancer (CC) is the sixth most common cause of death in India and third most important cause in developed countries. For treating cancer, several synthetic agents are available but they cause side effects. Therefore, there is a need to investigate plant derived anticancer agents with lesser side effects. In this direction, we have made an attempt to unravel the potential of pumpkin seed extract for treating colon cancer. Objective The objective of this study was to evaluate pumpkin seed extract as prophylactic and treatment for 1, 2-dimethylhydrazine (DMH) induced colon cancer in Wistar rats. Materials and Methods Male Wistar rats were divided into seven groups, namely, control, DMH (disease control), 5-Flurouracil (standard), treatment groups (100mg/kg and 200 mg/kg), and pretreatment groups (100mg/kg and 200 mg/kg) with pumpkin seed extract. The animals were euthanised at the end of study and colons were examined. Results A significant difference in the aberrant crypt foci (ACF) number in all treatment groups compared to control and DMH groups were noted. Pretreatment group at a dose of 200 mg/kg showed a significant decrease in the colon length/weight ratio. Pretreatment groups showed a significant change in the colonic glutathione (GSH) and superoxide dismutase (SOD) levels when compared to control and DMH control. The nitrite content was decreased in treatment group 200 mg/kg at 5.203±0.852 when compared to DMH control at 8.506±3.866. All treatment groups demonstrated decreased hyperplasia and ACF in histology. Conclusion Pumpkin seed may prevent the risk of CC when consumed in dietary proportions.

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Improvement in HDL cholesterol in postmenopausal women supplemented with pumpkin seed oil: pilot study

Abstract: This pilot study showed pumpkin seed oil had some benefits for postmenopausal women and provided strong evidence to support further studies.

Cited by 36 publications

References 33 publications

Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil

Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil

Changes in Acylglycerols Composition, Quality Characteristics and In vivo Effects of Dietary Pumpkin Seed Oil upon Thermal Oxidation

An Appraisal of Pumpkin Seed Extract in 1, 2-Dimethylhydrazine Induced Colon Cancer in Wistar Rats

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