Improvement of flow and bulk density of pharmaceutical powders using surface modification

Jallo, Laila J.; Ghoroi, Chinmay; Gurumurthy, Lakxmi; Patel, Utsav; Davé, Rajesh N.

doi:10.1016/j.ijpharm.2011.12.012

Cited by 145 publications

(72 citation statements)

References 31 publications

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“…10 The extent of the flow improvements for very fine ibuprofen powders that were simultaneously dry coated as compared with uncoated ones was outstanding, for example, flow function coefficient (FFC; a significant measure of flow property based on shear testing 11 ) for 10 :m ibuprofen increased 10 from about 1 to 6, which is a significant achievement as compared with that observed in dry coating performed without micronization, [12][13][14][15][16] for example, similar sized acetaminophen powder had FFC of about 2 and after dry coating increased to a little over 3. 15,17 Thus, it appears that the flow improvement phenomena because of dry coating during milling may be somewhat different, and in addition to silica creating separation, or more precisely, nanoscale surface roughness, 3,13 it may also be reducing overall surface energy as well as surface energy heterogeneity via passivating high-surfaceenergy sites on milled ibuprofen powders, leading to significantly improved flow properties. Accordingly, the objective of this paper is to examine this intriguing possibility through a systematic investigation of the influence of dry coating on surface energy of milled pharmaceutical crystals, in particular, the reasons for very high cohesion of milled powders in contrast to the improvements observed after dry coating.…”

Section: Introductionmentioning

confidence: 99%

“…14 Overall, such models show that the presence of nanosized guest particles on the API particle surface in a welldispersed manner can influence the contact geometry by changing the surface roughness. [12][13][14][15][29][30][31] Thus, on the basis of Eq. 1, silica coating will clearly impact terms d and SAC, thus reducing the adhesion force.…”

Section: Introductionmentioning

confidence: 99%

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Passivation of High-Surface-Energy Sites of Milled Ibuprofen Crystals via Dry Coating for Reduced Cohesion and Improved Flowability

Han

Jallo

et al. 2013

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Passivation of High-Surface-Energy Sites of Milled Ibuprofen Crystals via Dry Coating for Reduced Cohesion and Improved Flowability

Han

Jallo

et al. 2013

Journal of Pharmaceutical Sciences

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“…This is the most commonly used test for powder flowability by means of angle of repose (36). The angle of repose was measured by a fixed funnel method (37).…”

Section: Angle Of Reposementioning

confidence: 99%

Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique

Cheng

et al. 2015

AAPS PharmSciTech

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Abstract. The aim of this work was to establish a method for preparing stable and controllable solid selfmicroemulsifying drug delivery system (S-SMEDDS) by spherical crystallization technique, which was explored for promoting the dissolution, oral bioavailability, and process efficiency. Solubility test, preparation of liquid self-microemulsifying drug delivery system (L-SMEDDS), and the obtained ternary phase diagrams test have been performed to screen and optimize the composition of LSMEDDS. The optimized formulation was used to prepare puerarin solid self-microemulsifying drug delivery system (Pue-SSMEDDS) by spherical crystallization technique. Droplet size and morphological analysis of the optimal Pue-SSMEDDS were determined to evaluate the final formulation. And the Pue-SSMEDDS was also assessed by flowability study, angle of repose, Carr's index, and flow velocity. Furthermore, the vitro dissolution and pharmacokinetic profile in vivo were analyzed. The study in vitro showed the Pue-SSMEDDS could disperse in the dispersion medium within 60 s and was spherical with the particle size of 19.66 nm and zeta potential of −28.3 mV. It could keep stable at low temperature and seal condition for 3 months. In vivo pharmacokinetic experiments of rats, the mean plasma concentration of selfmicroemulsion group was much higher than that of conventional tablets and could play a long-lasting efficacy, while there was no significant difference between the LSMEDDS and S-SMEDDS. The results suggested the potential of S-SMEDDS could improve the oral bioavailability of poorly water-soluble drug, such as puerarin.

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“…Hence, the bulk density depends on both the density of powder particles and the spatial arrangement of particles in the powder bed (Jallo et al 2012). Tapped density (D t ) can be measured after mechanically tapping cylinder containing a powder sample (Santomaso et al 2003).…”

Section: Bulk and Tapped Density Of The Powdersmentioning

confidence: 99%

Solubility enhancement of celecoxib using solidified Tween 80 for the formulation of tablet dosage forms

Chakma

Khadka

et al. 2015

Journal of Pharmaceutical Investigation

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Celecoxib is a non-steroidal, anti-inflammatory drug used in the treatment of pain and inflammation associated with rheumatoid arthritis, and several other inflammatory disorders. It is a class II compound according to the Biopharmaceutics Classification System owing to its low water solubility and high membrane permeability. The objective of this study was to improve the solubility and dissolution rate of celecoxib using solid surfactant technology that might be useful in developing solid dosage forms. Solid surfactant was developed by mixing and grinding together a liquid surfactant (Tween 80) with various inorganic carriers like Fujicalin Ò (Dibasic Calcium Phosphate Anhydrous), Pineflow Ò (Porous-structured Maltodextrin), Neusilin Ò (Magnesium Alumino metasilicate) and Aerosil Ò (Colloidal Silicon dioxide) in a mortar and pestle in different ratios of liquid surfactant and the carrier to obtain solid surfactants. The celecoxib tablets prepared with solid surfactants were then evaluated for their solubility and dissolution properties. Among the fillers used, Fujicalin showed the highest solubilization capacity for celecoxib. The dissolution behaviors of various tablets prepared with solidified surfactants were compared to those of conventional celecoxib tablets in a simulated gastric fluid. Celecoxib tablets prepared using solidified surfactants showed improved dissolution behaviors when compared to the conventional counterparts. Fujicalin solidified Tween 80 was further analyzed by powder X-ray diffraction analysis, differential scanning calorimetry thermographs and reverse phase high performance liquid chromatography.

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Improvement of flow and bulk density of pharmaceutical powders using surface modification

Cited by 145 publications

References 31 publications

Passivation of High-Surface-Energy Sites of Milled Ibuprofen Crystals via Dry Coating for Reduced Cohesion and Improved Flowability

Passivation of High-Surface-Energy Sites of Milled Ibuprofen Crystals via Dry Coating for Reduced Cohesion and Improved Flowability

Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique

Solubility enhancement of celecoxib using solidified Tween 80 for the formulation of tablet dosage forms

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