Passivation of High-Surface-Energy Sites of Milled Ibuprofen Crystals via Dry Coating for Reduced Cohesion and Improved Flowability

Improving blend content uniformity via dry particle coating of micronized drug powders

“…In addition, coating with silica nanoparticles also leads to reduced surface energy at contact. As discussed in (Han et al, 2013), hydrophilic silica M5P particle A C C E P T E D M A N U S C R I P T 6 (~20nm) coated milled Ibuprofen (5µm) has a decreased dispersive surface energy (37.5 mJ/m 2 ) compared to uncoated milled Ibuprofen (54.5 mJ/m 2 ), leading to additional reductions in adhesion force.…”

“…As shown in section 2 based on mechanistic models, a significant decrease in inter-particle force occurs when most contacts are guest-guest, i.e., nanosized silica-nanosized silica particle contacts. In addition to the mechanistic effects explained through analysis of van der Waals type contact forces in section 2, the presence of nanoparticles may also alter the surface properties such as surface energy and electrostatic charge (Han et al, 2013;Jallo and Dave, 2015;Pfeffer et al, 2001;Zimmermann et al, 2004).…”

“…A more detailed description of surface energy analysis used in this study can be found in (Han et al, 2013).…”

“…The particle size of mAPAP and Avicel 102 was measured using a laser diffraction analysis (Rodos/Helos system, Sympatec, USA), following the procedure described in detail by (Han et al, 2013). …”

Influence of surface modification on wettability and surface energy characteristics of pharmaceutical excipient powders

“…Both surface wettability and energetics are prone to physical or chemical changes occurring on the solid surface. While wettability can be predominantly affected by the chemical nature of surfaces, the surface energy can be affected by various factors like powder processing or handling conditions, environmental conditions, particle size Han et al, 2013) etc.…”