Improvement of metastable crystal of acetaminophen via control of crystal growth rate

Nii, Kosuke; Maruyama, Mihoko; Okada, Shino; Adachi, Hiroaki; Takano, Kazufumi; Murakami, Satoshi; Yoshikawa, Hiroshi; Matsumura, Hideki; Inoue, Tsuyoshi; Imanishi, Masayuki; Tsukamoto, Katsuo; Yoshimura, Masashi; Mori, Yusuke

doi:10.7567/apex.11.035501

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…The needle-like crystals immediately transitioned to form II (prism-like crystals) at room temperature. Based on polymorphism control research with acetaminophen to date, it is speculated that the needle-like crystals obtained were trihydrate [30,31]. At room temperature, the supersaturations of form II (σ II ) and trihydrate (σ tri ) of the sample solutions were σ II = 0.75 and σ tri = −0.12 (unsaturation), so the trihydrate crystals were phase-transferred to form II.…”

Section: Resultsmentioning

confidence: 99%

Metastable Crystallization by Drop Impact

et al. 2022

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It has been reported that cavitation bubbles (air–liquid interface) by femtosecond laser and ultrasonic irradiations are effective for metastable phase crystallization in polymorph control. It has also been noted that cavitation bubbles are generated by mechanical shock when dropping a vial. Here we describe the crystallization of acetaminophen by drop impact. In the condition where spontaneous nucleation did not occur, the drop impact produced the metastable form (form II) and trihydrate. This supports the potency of the air–liquid interface in metastable phase formation. Furthermore, crystallization by drop impact is a completely new phenomenon, and new developments are expected in the future.

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Section: Resultsmentioning

confidence: 99%

Metastable Crystallization by Drop Impact

et al. 2022

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“…By this cycle, the transformation from COD to COM will gradually proceed. The solution-mediated transformation from a metastable phase to the stable phase often occurs in other materials [26][27][28]. Finally, the mosaic texture composed of irregular-oriented COM crystals appears from the center part of the kidney stone (Fig2.…”

Section: Discussionmentioning

confidence: 96%

Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

Maruyama

Sawada

Tanaka

et al. 2022

Preprint

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We aimed to identify and quantitatively analyze calcium oxalate (CaOx) kidney stones on the order of micrometers, with a focus on the quantitative identification of calcium oxalate monohydrate (COM) and dihydrate (COD). Fourier Transform Infrared (FTIR) spectroscopy, powder X-ray diffraction (PXRD), and microfocus X-ray CT measurements (micro-CT) were performed, and the results were compared. The extended analysis method of the FTIR spectrum, focusing on the 780 cm−1peak, made it possible to achieve a reliable analysis of the COM/COD ratio. We succeeded in the quantitative analysis of COM/COD in the region of 50 × 50 μm by microscopic FTIR for thin sections of kidney stones, and by the micro-CT for bulk samples. The extended analysis method of the FTIR spectrum focusing on the 780 cm−1peak was introduced to analyze the COM/COD ratio. The analysis results based on PXRD measurement with micro sampling, microscopic FTIR analysis of a thin section, and micro-CT observation of a bulk sample of a kidney stone showed roughly consistent results, indicating that all methods can be used complementarily. This quantitative analysis method evaluates the detailed CaOx composition on the preserved stone surface and provides information on the stone formation processes and interactions with organic molecules.

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Section: Plos Onementioning

confidence: 99%

Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

et al. 2023

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We sought to identify and quantitatively analyze calcium oxalate (CaOx) kidney stones on the order of micrometers, with a focus on the quantitative identification of calcium oxalate monohydrate (COM) and dihydrate (COD). We performed Fourier transform infrared (FTIR) spectroscopy, powder X-ray diffraction (PXRD), and microfocus X-ray computed tomography measurements (microfocus X-ray CT) and compared their results. An extended analysis of the FTIR spectrum focusing on the 780 cm−1 peak made it possible to achieve a reliable analysis of the COM/COD ratio. We succeeded in the quantitative analysis of COM/COD in 50-μm2 areas by applying microscopic FTIR for thin sections of kidney stones, and by applying microfocus X-ray CT system for bulk samples. The analysis results based on the PXRD measurements with micro-sampling, the microscopic FTIR analysis of thin sections, and the microfocus X-ray CT system observation of a bulk kidney stone sample showed roughly consistent results, indicating that all three methods can be used complementarily. This quantitative analysis method evaluates the detailed CaOx composition on the preserved stone surface and provides information on the stone formation processes. This information clarifies where and which crystal phase nucleates, how the crystals grow, and how the transition from the metastable phase to the stable phase proceeds. The phase transition affects the growth rate and hardness of kidney stones and thus provides crucial clues to the kidney stone formation process.

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Improvement of metastable crystal of acetaminophen via control of crystal growth rate

Cited by 9 publications

References 18 publications

Metastable Crystallization by Drop Impact

Metastable Crystallization by Drop Impact

Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

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