Improvements in skin quality parameters in postmenopausal participants after use of topical growth factor serum

Abstract

Background Photodamage can induce skin aging processes that can be particularly concerning for postmenopausal women. Growth factors from hypoxic human fibroblast‐conditioned media have demonstrated improvements in skin quality parameters. Aims The aim of the study was to assess efficacy and tolerability of topical combination‐treatment hypoxic growth factor serum (TNS A+) in postmenopausal women with moderate to severe facial photodamage. Patients/Methods In this 12‐week, open‐label, single‐center study, participants used TNS A+ serum twice daily. Postmenopausal women (40–65 years of age) with Fitzpatrick skin types I–VI and modified Griffiths scale scores 4–9 were eligible. Clinical and participant‐reported assessments were evaluated at Weeks 6 and 12. Statistical significance was defined as p ≤ 0.05. Results There were 17 enrolled participants. TNS A+ treatment demonstrated significant improvements from baseline in fine lines and wrinkles in periocular, forehead, and cheek areas at Week 12 and the perioral area at Weeks 6 and 12. Significant improvements from baseline in coarse lines and wrinkles were observed for the perioral area at Week 12 and periocular and cheek areas at Weeks 6 and 12. Improvements in overall photodamage, skin tone evenness, and tactile roughness were significantly greater at Weeks 6 and 12 versus baseline. Most participants reported TNS A+ made their skin look and feel smooth, soft, and rejuvenated; improved skin radiance; made lines and wrinkles less apparent; and improved skin texture. No treatment‐related adverse events were reported. Conclusions The TNS A+ regimen was well tolerated and provided significant improvements in skin quality in postmenopausal women with moderate to severe facial photodamage.

Fibroblast‐derived growth factors and exosomes as cosmeceuticals

“…Clinical studies on hypoxic FB secretome have shown significant impacts on key skin rejuvenation parameters including overall photodamage and coarse wrinkles, with patient‐reported outcomes assessing age appearance corroborating the improvements observed in grading assessments and biopsy sample analysis. In addition, similar improvements were also achieved by topical hypoxic FB secretome in post‐menopausal females 29,30 …”

“…In addition, similar improvements were also achieved by topical hypoxic FB secretome in post-menopausal females. 29,30…”

Topical growth factor preparations for facial skin rejuvenation: A systematic review

“…Table 1 summarizes the 33 identified studies and highlights study design, treatments, and methods of evaluation 29–62 . There were nine RCTs (7 double‐blind and 2 single‐blind) 30,32–34,37,42,46,48,56,59 and 24 CS studies 29,31,35,36,38–40,43–45,47,49–55,57,58,60–62 .…”

Efficacy and tolerability of a novel cosmetic growth factor serum when used as part of biweekly diamond tip hydradermabrasion treatments on facial skin

“…These underlying factors, exacerbated in women by declining levels of estrogen at menopause, lead to progressive loss of skin elasticity and firmness, development of fine and coarse lines and wrinkles, uneven skin tone, and sagging. [1][2][3] Consistent with these mechanisms, topical application of human fibroblast-generated growth factors has demonstrated the ability to rejuvenate aging skin. In early studies, neonatal human dermal fibroblasts cultured under normoxic physiological conditions were found to secrete a complex, balanced mixture of growth factors, cytokines, and ECM proteins involved in wound healing.…”

“…[9][10][11] HCCM-based topical formulations, used as monotherapy or as adjuncts to aesthetic procedures, have demonstrated efficacy against common signs of aging and in postprocedure healing in clinical studies. 2,[10][11][12][13][14] TNS® Advanced+ Serum (TNS A+ Serum; SkinMedica®, Allergan Aesthetics, an AbbVie Company, Irvine, CA, USA) is a novel topical hypoxic growth factor serum product containing HCCM in combination with active botanical ingredients; its development and components are described in a separate manuscript. 10 In clinical studies, TNS A+ Serum has demonstrated the ability to significantly improve multiple hallmarks of aging skin (e.g., photodamage, sagging, coarse lines and wrinkles, and fine lines and wrinkles); whereas in an in vitro human skin model, TNS A+ Serum upregulates ECM-associated genes.…”