Improvements of immune status, intestinal integrity and gain performance in the early-weaned calves parenterally supplemented with l-alanyl-l-glutamine dipeptide

Zhou, Yanmin; Zhang, Pei-song; Deng, Guangcun; Liu, Xiaoming; De-xun, LU

doi:10.1016/j.vetimm.2011.10.020

Cited by 34 publications

(25 citation statements)

References 48 publications

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“…The data on the mRNA levels for some positive regulators, including CD28, B7 and IL-5, in the spleen also support this conclusion. Although previous investigations have reported that glutamine supplementation increases the levels of serum IgG and IgA (Zhong et al 2012;Zhou et al 2012 antibodies participate in general, rather than pathogen-specific, defense responses. In support of this view, we have observed that glutamine supplementation increases the production and transportation of secretory IgA by the small intestine (our unpublished data).…”

Section: Discussionmentioning

confidence: 84%

Effects of dietary l-glutamine supplementation on specific and general defense responses in mice immunized with inactivated Pasteurella multocida vaccine

et al. 2014

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Little is known about effects of dietary glutamine supplementation on specific and general defense responses in a vaccine-immunized animal model. Thus, this study determined roles for dietary glutamine supplementation in specific and general defense responses in mice immunized with inactivated Pasteurella multocida vaccine. The measured variables included: (1) the production of pathogen-specific antibodies; (2) mRNA levels for pro-inflammatory cytokines, toll-like receptors and anti-oxidative factors; and (3) the distribution of P. multocida in tissues and the expression of its major virulence factors in vivo. Dietary supplementation with 0.5 % glutamine had a better protective role than 1 or 2 % glutamine against P. multocida infection in vaccine-immunized mice, at least partly resulting from its effects in modulation of general defense responses. Dietary glutamine supplementation had little effects on the production of P. multocida-specific antibodies. Compared to the non-supplemented group, dietary supplementation with 0.5 % glutamine had no effect on bacterial burden in vivo but decreased the expression of major virulence factors in the spleen. Collectively, supplementing 0.5 % glutamine to a conventional diet provides benefits in vaccine-immunized mice by enhancing general defense responses and decreasing expression of specific virulence factors.

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Section: Discussionmentioning

confidence: 84%

Effects of dietary l-glutamine supplementation on specific and general defense responses in mice immunized with inactivated Pasteurella multocida vaccine

et al. 2014

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“…; Zhou et al . ). However, there is little information about supplementary concentrate to early weaned yaks.…”

Section: Introductionmentioning

confidence: 97%

Effects of different levels of protein supplementary diet on gene expressions related to intramuscular deposition in early‐weaned yaks

Zhang

Wang

Peng

et al. 2014

Animal Science Journal

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This study was conducted to estimate different levels of protein supplementary diet on gene expressions related to intramuscular deposition in early-weaned yaks. Results showed that supplementary dietary protein significantly increased final weight, average daily gain (ADG), intramuscular fat (IMF), serum free fatty acid (FFA), total triglycerides, total cholesterol (Ch), low-density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) content. There was a quadratic response of ADG, IMF, FFA, Ch, HDL and LDL to dietary crude protein (CP) level. Lipoprotein lipase (LPL), fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) enzyme activities were significantly increased by supplementary dietary CP, while hormone-sensitive lipase (HSL) and carnitine palmitoyltransferase-1 (CPT-1) activities were significantly decreased. LPL, ACC and FAS enzyme activities showed quadratic increase as dietary CP increased. Peroxisome proliferator-activated receptor γ (PPARγ), LPL, FAS, sterol regulatory element binding protein 1 (SREBP-1), ACC, stearoyl-CoA desaturase (SCD) and heart fatty-acid binding protein (H-FABP) gene expression were significantly increased by supplementary dietary CP, while HSL and CPT-1 gene expression were significantly decreased. PPARγ, LPL, SREBP-1, ACC and H-FABP gene expression showed quadratic increase as dietary CP increased. These results indicated that supplementary dietary protein increased IMF accumulation mainly to increased intramuscular lipogenic gene expression and decreased lipolytic gene expression.

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“…Results of these interesting investigations suggest that glutamine has critical importance in intestinal immunity. Indeed, glutamine promotes the secretion of intestinal SIgA in rats with liver transplantation , in a rat model of short bowel syndrome , and in septic rats , and other models, such as mice , calves and chickens . However, the mechanism by which glutamine promotes intestinal SIgA secretion is largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Glutamine promotes intestinal SIgA secretion through intestinal microbiota and IL‐13

Xiao

Liu

et al. 2016

Molecular Nutrition Food Res

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Improvements of immune status, intestinal integrity and gain performance in the early-weaned calves parenterally supplemented with l-alanyl-l-glutamine dipeptide

Cited by 34 publications

References 48 publications

Effects of dietary l-glutamine supplementation on specific and general defense responses in mice immunized with inactivated Pasteurella multocida vaccine

Effects of dietary l-glutamine supplementation on specific and general defense responses in mice immunized with inactivated Pasteurella multocida vaccine

Effects of different levels of protein supplementary diet on gene expressions related to intramuscular deposition in early‐weaned yaks

Glutamine promotes intestinal SIgA secretion through intestinal microbiota and IL‐13

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