New helicopter rotor designs are desired that offer increased efficiency, reduced vibration, and reduced noise. Multidisciplinary optimization of rotors has been advanced by the development of "comprehensive" rotorcraft analysis tools; however, these tools lack built-in high-fidelity aerodynamic models. Accurate airload predictions utilize computational fluid dynamics (CFD) coupled to the computational structural dynamics (CSD) of a comprehensive code. These methods are too computationally intensive for numerous function calls as in optimization. Thus, an approach is needed where high-fidelity simulations can be routinely used in optimization. The process presented in this paper combines the results of a simplified aerodynamic low-fidelity simulation with a selected number of high-fidelity CFD/CSD simulations. The process is demonstrated for a four-bladed hingeless rotor. Design variables include tip geometry and spanwise twist. Approximation models are built for high-fidelity metrics for rotor efficiency and vibration. Optimization using these approximation models found a design having maximum rotor efficiency while constraining vibration.