For the sustainable use of building spaces, various methods have been studied to satisfy specific conditions required by the characteristics of space types and the energy use in operation. However, several effective control approaches adopting the latest statistical tools may have problems such as higher control precision increases energy consumption, or lower energy consumption decreases their control precision. This study proposes an optimized model to reach the indoor set-point temperature by controlling the amount of heating supply air and its temperature and investigates the efficiency of an adaptive controller to maintain indoor thermal comfort within setting ranges. In the consistency of the comfort level, the fuzzy logic controller was found to be 1.76% and the artificial neural network controller to be 17.83%, respectively, more efficient than the conventional thermostat. In addition, for energy use efficiency, both of the controllers were confirmed to be over 3.0% more efficient. Consequently, the network-based controller with the adaptive controller checking comfort levels effectively works to improve both energy efficiency and thermal comfort. This improvement can be significant in places such as commercial high-rises, large hospitals, and data centers where many spaces are intensively woven with appropriate thermal environments to maintain users’ workability.