Improving the Sensitivity of SPR Sensors with Au–Ag alloys and 2D Materials — a Simulation‐Based Approach

Das, Chandreyee Manas; Guo, Yan; Kang, Lixing; Poenar, Daniel Puiu; Xiong, Jiaqing; Ramaswamy, Yogambha; Martínez-Martín, David; Yong, Ken‐Tye

doi:10.1002/adts.202100292

Cited by 4 publications

(4 citation statements)

References 49 publications

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“…SPR sensors have the advantages of label-free and real-time detection, high sensitivity and selectivity, fast measurement, etc. 15 Benefiting from the above characteristics, SPR-based sensors have been widely used for the study of biomolecular interactions and have found applications in biological assays and medical diagnosis. 16 Au is commonly used as the active metal for SPRbased sensors.…”

Section: Spr-based Sensorsmentioning

confidence: 99%

“…Based on this, SPR could be implemented in the detection of molecular binding events, including affinity and kinetics. SPR sensors have the advantages of label‐free and real‐time detection, high sensitivity and selectivity, fast measurement, etc 15 . Benefiting from the above characteristics, SPR‐based sensors have been widely used for the study of biomolecular interactions and have found applications in biological assays and medical diagnosis 16…”

Section: Optical Sensing Mechanisms and Sensor Materialsmentioning

confidence: 99%

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Microfluidic preparation of optical sensors for biomedical applications

Wang

Yang

et al. 2023

Smart Medicine

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Optical biosensors are platforms that translate biological information into detectable optical signals, and have extensive applications in various fields due to their characteristics of high sensitivity, high specificity, dynamic sensing, etc. The development of optical sensing materials is an important part of optical sensors. In this review, we emphasize the role of microfluidic technology in the preparation of optical sensing materials and the application of the derived optical sensors in the biomedical field. We first present some common optical sensing mechanisms and the functional responsive materials involved. Then, we describe the preparation of these sensing materials by microfluidics. Afterward, we enumerate the biomedical applications of these optical materials as biosensors in disease diagnosis, drug evaluation, and organ‐on‐a‐chip. Finally, we discuss the challenges and prospects in this field.

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Section: Spr-based Sensorsmentioning

confidence: 99%

Section: Optical Sensing Mechanisms and Sensor Materialsmentioning

confidence: 99%

Microfluidic preparation of optical sensors for biomedical applications

Wang

Yang

et al. 2023

Smart Medicine

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“…Nanomaterials are the most ideal material for their fabrication and better signal detection and amplification. Most importantly they are available commercially (Deng et al, 2017;Das et al, 2021).…”

Section: Surface Plasmon Resonance-based Dna Sensors (Sprs)mentioning

confidence: 99%

Nucleotide detection mechanism and comparison based on low-dimensional materials: A review

Azeem

Shafa²,

Aamir³

et al. 2023

Front. Bioeng. Biotechnol.

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The recent pandemic has led to the fabrication of new nucleic acid sensors that can detect infinitesimal limits immediately and effectively. Therefore, various techniques have been demonstrated using low-dimensional materials that exhibit ultrahigh detection and accuracy. Numerous detection approaches have been reported, and new methods for impulse sensing are being explored. All ongoing research converges at one unique point, that is, an impetus: the enhanced limit of detection of sensors. There are several reviews on the detection of viruses and other proteins related to disease control point of care; however, to the best of our knowledge, none summarizes the various nucleotide sensors and describes their limits of detection and mechanisms. To understand the far-reaching impact of this discipline, we briefly discussed conventional and nanomaterial-based sensors, and then proposed the feature prospects of these devices. Two types of sensing mechanisms were further divided into their sub-branches: polymerase chain reaction and photospectrometric-based sensors. The nanomaterial-based sensor was further subdivided into optical and electrical sensors. The optical sensors included fluorescence (FL), surface plasmon resonance (SPR), colorimetric, and surface-enhanced Raman scattering (SERS), while electrical sensors included electrochemical luminescence (ECL), microfluidic chip, and field-effect transistor (FET). A synopsis of sensing materials, mechanisms, detection limits, and ranges has been provided. The sensing mechanism and materials used were discussed for each category in terms of length, collectively forming a fusing platform to highlight the ultrahigh detection technique of nucleotide sensors. We discussed potential trends in improving the fabrication of nucleotide nanosensors based on low-dimensional materials. In this area, particular aspects, including sensitivity, detection mechanism, stability, and challenges, were addressed. The optimization of the sensing performance and selection of the best sensor were concluded. Recent trends in the atomic-scale simulation of the development of Deoxyribonucleic acid (DNA) sensors using 2D materials were highlighted. A critical overview of the challenges and opportunities of deoxyribonucleic acid sensors was explored, and progress made in deoxyribonucleic acid detection over the past decade with a family of deoxyribonucleic acid sensors was described. Areas in which further research is needed were included in the future scope.

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“…At the same time, the adsorption capacity of metals for biomolecules is limited, which can greatly limit the sensitivity of biosensors. One of the most effective ways to lift the limitations of traditional SPR biosensors is to coat the biosensor structures with two-dimensional (2D) materials [ 12 , 13 ]. Most 2D materials have excellent time stability [ 14 ], which protects the metals in biosensors from oxidation, so as to improve the overall durability.…”

Section: Introductionmentioning

confidence: 99%

High-Sensitivity PtSe2 Surface Plasmon Resonance Biosensor Based on Metal-Si-Metal Waveguide Structure

et al. 2022

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PtSe2 as a novel TMDCs material is used to modify the traditional SPR biosensors to improve the performance. On this basis, this research proposes a metal-Si-metal waveguide structure to further improve the performance of the biosensor. In this study, we not only studied the effects of waveguide structures containing different metals on the performance of biosensor, but also discussed the performance change of the biosensor with the change of PtSe2 thickness. After the final optimization, a BK7-Au-Si-Au-PtSe2 (2 nm) biosensor structure achieved the highest sensitivity of 193.8°/RIU. This work provides a new development idea for the study of SPR biosensors with waveguide structures in the future.

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Improving the Sensitivity of SPR Sensors with Au–Ag alloys and 2D Materials — a Simulation‐Based Approach

Cited by 4 publications

References 49 publications

Microfluidic preparation of optical sensors for biomedical applications

Microfluidic preparation of optical sensors for biomedical applications

Nucleotide detection mechanism and comparison based on low-dimensional materials: A review

High-Sensitivity PtSe2 Surface Plasmon Resonance Biosensor Based on Metal-Si-Metal Waveguide Structure

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