Imunopatogenesis dan Implikasi Klinis Alergi Makanan pada Dewasa

Kam, Alexander; Raveinal, Raveinal

doi:10.25077/jka.v7i0.842

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…This is because patients generally do not seek medical attention immediately or tell their doctor about the history of these symptoms. 31 In patients with acute urticaria, the dominant allergens were found to be house dust mites, soybeans, shellfish, crabs, and shrimp.…”

Section: Discussionmentioning

confidence: 99%

Skin Prick Test Profile: A Retrospective Study

Nopriyati

Antonius²,

Thaha

et al. 2022

BIKK

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Background: A skin prick test is one method to detect allergies. Skin prick testing in dermatology can be performed on atopic dermatitis and urticaria. Skin prick test can be done easily, it’s relatively safe, fast, and can use many allergens simultaneously in one test. Purpose: To describe the characteristics of the skin prick test results at the clinic of Dermatology and Venereology, Mohammad Hoesin Palembang General Hospital, for the period 2016-2021. Methods: Descriptive retrospective study using a cross-sectional approach. Medical record data for the period January 2016-December 2021. Result: The number of patients who underwent skin prick testing during the period January 2016 to December 2021 was 116 patients, dominated by women (59.5%) and those aged 26-35 years (40.5%). The majority of diagnoses examined were atopic dermatitis (48.3%) and chronic urticaria (31.9%). The most positive results were for allergens in the form of house dust mites, shrimp, and crabs. The positive proportion of milkfish allergen was higher in women, while the positive proportion of shrimp allergen was higher in men. Chicken feather allergen showed significant differences between the diagnoses of atopic dermatitis, chronic urticaria and acute urticaria. Conclusion: House dust mites were the dominant allergen in patients with atopic dermatitis, chronic urticaria, and acute urticaria. skin prick test is recommended to be performed in the management of atopic dermatitis, chronic urticaria, and acute urticaria in order to detect the allergen because it has signiﬁcant clinical relevance.

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Section: Discussionmentioning

confidence: 99%

Skin Prick Test Profile: A Retrospective Study

Nopriyati

Antonius²,

Thaha

et al. 2022

BIKK

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“…Alergi pangan merupakan suatu masalah kesehatan yang dapat dialami oleh setiap kalangan dan kebanyakan wanita dewasa dan anak-anak (Kam & Raveinal 2018). Penderita alergi pangan mengalami serum IgE yang meningkat (Al-Falahi, 2020).…”

Section: Pendahuluanunclassified

Penentuan Struktur Tiga Dimensi dan Profil Hasil Hidrolisis Protein Alergen Arginin Kinase Secara in silico

Mahgfirah¹,

Prangdimurti²,

Palupi³

et al. 2022

J.Wart.Industri.Has.Pertan.

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Alergi pangan ialah suatu reaksi hipersensitivitas melalui mekanisme imunologis setelah terpapar alergen dari suatu bahan pangan. Arginin kinase dengan kode alergen (Pen m 2) merupakan alergen yang terdapat di bahan pangan udang windu (Penaeus monodon) dan dapat memicu terjadinya alergi. Tujuan dari penelitian ini untuk mendapatkan struktur tiga dimensi dan mendapatkan profil hidrolisat arginin kinase secara in silico. Metode penelitian dengan tahap pertama ialah pencarian identitas dan karakteristik fisikokimia arginine kinase berupa family, berat molekul, nilai pI teoritis, nilai grand average of hidropathicity (GRAVY) dan indeks kestabilan. Selanjutnya tahap kedua ialah penentuan struktur tiga dimensi. Tahap ketiga ialah memprediksi profil hasil hidrolisis protein alergen arginin kinase secara enzimatis (pepsin, tripsin dan kimotripsin) dan non-enzimatis (asam format). Hasil dari penelitian ini menjelaskan bahwa Pen m 2 merupakan family ATP:guanido phosphotransferase dengan pola kinase fosfagen. Struktur tiga dimensi Arginin kinase (Pen m 2) memiliki hasil identitas sekuens 96,91% dan nilai Ramachandran favoured ialah 97,18%. Hidrolisis arginin kinase menggunakan enzim pepsin, kimotripsin dan tripsin menghasilkan peptida terpanjang 11 asam amino (berat molekul 1210 Da), sehingga menunjukkan penurunan alergenisitas arginin kinase (Pen m 2). Hidrolisis menggunakan asam format menghasilkan peptida terpanjang ialah 69 asam amino (berat molekul 7590 Da) yang masih berpotensi alergenik Kata kunci: arginin kinase, in silico, pemotongan peptida, SWISS-MODEL, udang ABSTRACT: Food allergy is a hypersensitivity reaction through an immunological mechanism after exposure to an allergen from a food ingredient. Arginine kinase with an allergen code (Pen m 2) is an allergen found in tiger prawns (Penaeus monodon) and can trigger allergies. This study aimed to obtain a three-dimensional structure and an in silico profile of arginine kinase hydrolyzate. The research method in the first stage is the search for identity and physicochemical characteristics of arginine kinase in the form of family, molecular weight, theoretical pI value, and grand average of hydropathicity (GRAVY) and stability index. The second stage is the determination of the three-dimensional structure. The third step is to predict the profile of the hydrolysis of the allergen arginine kinase protein enzymatically (pepsin, trypsin and chymotrypsin) and non-enzymatically (formic acid). The results of this study explain that Pen m 2 is a family of ATP:guanido phosphotransferases with a phosphagen kinase pattern. The three-dimensional structure of Arginine kinase (Pen m 2) has a sequence identity result of 96.91%, and the Ramachandran favoured value is 97.18%. Hydrolysis of arginine kinase using the enzymes pepsin, chymotrypsin and trypsin resulted in the longest peptide of 11 amino acids (molecular weight 1210 Da), thus indicating a decrease in the allergenicity of arginine kinase (Pen m 2). Hydrolysis using formic acid resulted in the most extended peptide being...

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Imunopatogenesis dan Implikasi Klinis Alergi Makanan pada Dewasa

Cited by 2 publications

References 19 publications

Skin Prick Test Profile: A Retrospective Study

Skin Prick Test Profile: A Retrospective Study

Penentuan Struktur Tiga Dimensi dan Profil Hasil Hidrolisis Protein Alergen Arginin Kinase Secara in silico

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