The rapid growth of Battery Electric Vehicles (BEVs) in the automotive field has led to a need for improving their drivetrain performance, mainly focusing on the extension of the battery operating range. However, the majority of performed technical assessments only consider battery SoC and depth of discharge while neglecting the effects on lifetime and failure probability of power electronic components, more specifically the emerging wide-bandgap-based (WBG) technologies. Toward fulfilling this gap, the EV market demands lifetime estimation performed under real-life mission profile to confirm efficiency and reliable operation of EV power electronics for an extended range meeting the EVs lifetime requirements. In this regard, the present study proposes a versatile experimental device-under-test setup to investigate a novel stepwise holistic system-level lifetime estimation approach for BEV drivetrains equipped with SiC interleaved bidirectional HV DC/DC converter (IBC). To this end, three different real-life mission profile use-cases are investigated in this paper and provides systematic stress-based lifetime estimation, statistical analyses, and validations in comparison. The study outcome highlights realistic information related to significant impacts of operation range and battery SoC features on the IBC lifetime from all aspects.