In-line monitoring of sitagliptin dissolution profile from tablets utilizing an eco-friendly potentiometric sensor

Elhassan, Manar M.; Mahmoud, Amr M.; Hegazy, Maha A.; Mowaka, Shereen

doi:10.1007/s11696-021-01646-3

Cited by 20 publications

(11 citation statements)

References 42 publications

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“…Nowadays, the environment protection and the personal health and safety are considered in the eld of chemistry, that led to increasing number of published articles about how to work according to green principles and guidelines to obtain better clean handling of chemistry 17 . GAC has been considered in different techniques such as spectrophotometry 18 , spectro uorimetry 19 , electrochemistry 20 and chromatography 21 . The methods for evaluating greenness of an analytical method should be quantitative, and consistent evaluating methods.…”

Section: Ibuprofen (Ibu) (2rs)-2-[4-(2-methylpropylmentioning

confidence: 99%

Development of an eco-friendly HPLC method for the stability indicating assay of binary mixture of ibuprofen and phenylephrine

Kelani

Fayez

Abdel-Raoof

et al. 2023

Preprint

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The development and validation of the stability indicating HPLC technique has contributed to the understanding of the stability profile of ibuprofen (IBU) and phenylephrine (PHE). Stability profile was achieved for PHE, the drug was found to be liable to be influenced by stress oxidative conditions. Two oxidative degradates were formed and their structures were confirmed using IR and mass spectrometry. The drugs and degradation products were successfully separated using a a gradient elution method on YMC-C8 column with 0.1% hexanesulfonic acid and acetonitrile as solvents at pH 6.6. The flow rate was 1.0 mL.min− 1, and a diode array detector operating at 220 nm was used for UV detection. The proposed technique has been validated using ICH guidelines and its greenness was assessed according to Analytical Eco Scale metric.

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Section: Ibuprofen (Ibu) (2rs)-2-[4-(2-methylpropylmentioning

confidence: 99%

Development of an eco-friendly HPLC method for the stability indicating assay of binary mixture of ibuprofen and phenylephrine

Kelani

Fayez

Abdel-Raoof

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Electrochemical methods are considered inherently green techniques through the use of water and buffers as the main solvents. Moreover, potentiometric measurements are time and cost-effective, besides being simple with very few sample pre-treatment steps [ 7 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of Clomipramine using eco-friendly solid-contact ionophore-doped potentiometric sensor

2023

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Introduction Clomipramine is a tricyclic antidepressant acting as a serotonin reuptake inhibitor. Its maximum plasma concentration (Cmax) is 13–310 ng/mL, the therapeutic range is 220–500 ng/mL and its toxic effect appears in doses above 900 ng/mL. Objectives The fabrication of eco-friendly solid-contact ion-selective electrodes to evaluate the concentration of Clomipramine in different matrices based on disposable screen-printed carbon electrode. Methods Disposable screen-printed carbon electrode was utilized as a substrate to fabricate the proposed sensors. The sensors were optimized to determine Clomipramine using calix[4]arene as an ionophore into PVC polymeric membrane to enhance selectivity towards the target analyte. The solid-contact sensor potential stability was improved by the incorporation of graphene nanoparticles transducer layer. Results The sensors were assessed as per the IUPAC recommendations. The linearity range was 1 × 10− 2 to 1 × 10− 5.3 M. The sensors were successfully applied to determine CLM in the pharmaceutical formulation. Furthermore, the ion selective electrodes were applied for Clompiramine assay in spiked plasma for the purpose of Point-of-Care testing to be a diagnostic tool for therapeutic monitoring of the cited central nervous system agent. The findings were statistically compared to the reported method showing no statistically significant difference. Conclusion This work was concerned with developing a green analytical method for the determination of Clomipramine. The proposed SC-ISE was mixed with graphene nanocomposite transducer interlayer. The graphene layer succeeded in preventing the formation of an aqueous layer so resulted in a stable, reproducible standard potential besides the rapid response time.

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“…[27,28] Due to the significance of potentiometric sensors for sitagliptin analysis, some conventional polymeric liquid membrane electrodes have been introduced for this drug. [29][30][31][32] Nevertheless, all of these reported electrodes were prevalent liquid membrane electrodes with an internal solution, which inherently contains drawbacks like less mechanical stability, more ohmic resistance and higher detection limit because of concentration diffusion through the membrane from the internal solution side. [33] These disadvantages restrict the practical application of these liquid membrane electrodes to determine low-level detection of SG in different real samples having a concentration lower than micromolar.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Chemically Modified Carbon Paste Sensor for Reliable and Selective Potentiometric Determination of Trace Amounts of Sitagliptin in Real Samples

2022

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A new chemically modified potentiometric carbon paste electrode was fabricated based on incorporation of the ion association complex of sitagliptin‐phosphotungstate to determine sitagliptin. The proposed sensor displayed a Nernstian slope of 59.4 mV/decade for sitagliptin over a concentration range of 1.7×10−8 to 2.2×10−5 M and a detection limit of 9.1×10−9 M. It represented the advantages of fast response, long lifetime and, most importantly, excellent selectivity for sitagliptin versus a wide variety of usual inorganic cations and also biological species such as amino acids and sugars. The temperature dependence of sensor potential was examined, and it was figured out that the sensor has a low thermal coefficient in the temperature range of 15–55 °C. The sensor was applied to determine sitagliptin in pharmaceutical tablets, milk and blood serum samples. The obtained suitable recoveries and relative standard deviations confirmed that the developed sensor could be precisely applied to determine sitagliptin in real samples.

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In-line monitoring of sitagliptin dissolution profile from tablets utilizing an eco-friendly potentiometric sensor

Cited by 20 publications

References 42 publications

Development of an eco-friendly HPLC method for the stability indicating assay of binary mixture of ibuprofen and phenylephrine

Development of an eco-friendly HPLC method for the stability indicating assay of binary mixture of ibuprofen and phenylephrine

Determination of Clomipramine using eco-friendly solid-contact ionophore-doped potentiometric sensor

Ultrasensitive Chemically Modified Carbon Paste Sensor for Reliable and Selective Potentiometric Determination of Trace Amounts of Sitagliptin in Real Samples

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