Understanding of the deformation micro-mechanism as a function of grain orientation during cyclic loading is of significant importance to have failure safe design of structural components made of commercially pure titanium (CP-Ti). The evolution of deformation microstructure and texture of commercially pure titanium samples with prismatic-pyramidal (orientation A) and near basal (orientation B) as initial texture along the loading direction has been investigated during load reversal at ±8% and ±12% strain using in-situ synchrotron X-ray diffraction. The synchrotron X-ray diffraction results have been further complemented with Elastic-Plastic Self-Consistent (EPSC) simulation of the texture data and ex-situ Electron backscatter diffraction (EBSD) scan taken at the same region. Orientation A showed partially reversible texture whereas