In search of bioinspired hydrogels from amphiphilic peptides: a template for nanoparticle stabilization for the sustained release of anticancer drugs

Abstract

This report presents the efficiency of palmitic acid-based proteolytically stable, biocompatible hydrogelators for the sustained release of anticancer drugs.

Chiral Orchestration: A Tool for Fishing Out Tripeptide-Based Mechanoresponsive Supergelators Possessing Anti-Inflammatory and Antimicrobial Properties

“…30 The IC 50 values of Hydrogelators I−IV were found to be 252.2, 281.9, 242.2, and 296.4 μg/mL, respectively, which were considered to be safe for biomedical applications. 61,54 Also, the hydrogelators showed negligible hemolysis at MIC for all of the microorganisms. The hemolysis data have been summarized in Figure 6B and Table S4.…”

“…Indeed, the patterns showed characteristic peaks at 19.12–19.25° ( d = 4.6 Å) and 22.4–22.8° ( d = 3.7 Å), respectively, emphasizing the presence of β-sheets stabilized by π–π stacking of phenyl rings of phenylalanine (Figures B and S9). − …”

“…The dose-dependent cell viability experiments by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in the HEK 293 (human embryonic kidney cell) cell line were conducted by incubating the latter for 48 h as shown in Figure A and Table S3 . The IC 50 values of Hydrogelators I – IV were found to be 252.2, 281.9, 242.2, and 296.4 μg/mL, respectively, which were considered to be safe for biomedical applications. , Also, the hydrogelators showed negligible hemolysis at MIC for all of the microorganisms. The hemolysis data have been summarized in Figure B and Table S4. , It has been observed that the hydrogelators were very effective even at 10 times the MIC of Staphylococcus aureus and thrice the value for Streptococcus mutans.…”

Biomimetic Growth of Hydroxyapatite on SiO2 Microspheres to Improve Its Biocompatibility and Gentamicin Loading Capacity

“…HAp nuclei formation is facilitated with this process, which occurs spontaneously, consuming Ca 2+ and PO 4 3− ions present in SBF solution [7,12,13]. The synthesis of SiO 2 microspheres by the Stöber method and using various surfactants as templates to employ them in various applications have been previously reported [14][15][16]. However, the use of surfactants during SiO 2 synthesis to control shape and size may affect biocompatibility, even in trace amounts, since most surfactants are cytotoxic [17][18][19].…”

Preparation of biocompatible hydrogels reinforced by different nanosheets

“…The inclusion of nanosheets in host matrices (hydrogels here) can be seen as host-guest materials where host-guest interactions represent a key point favoring the possible entanglements between colloids that can be multiplied or in contrast screened leading to the spread of the gelation on a wide range of temperatures with some domains that are impossible to reach using only bulk hydrogels. [25][26][27][28][29] Depending on the affinity and the strength of the interaction between host-guest materials as well as the proper dispersion of the nanosheets that can even form gels in solvents at high concentrations as recent studies pointed out, 26,29 the gelation can be shied to low or high temperature while affecting the global elastic properties of the composites.…”