In silico analysis of new flavonoids from Pongamia pinnata with a therapeutic potential for age-related macular degeneration

Das, Srijan; Tiwari, Gopal Ji; Ghosh, Anindita

doi:10.1007/s13205-020-02537-2

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…3 P. pinnata extract contains many flavonoid compounds, namely Karanjin, Karanjachromene, Pongapin, and Pongachromene. 4 These compounds have a neuroprotective function in Alzheimer's disease. 5 However, its use as an apoptosis inhibitor in ischemic stroke has never been evaluated.…”

Section: Introductionmentioning

confidence: 99%

In Silico Analysis of Pongamia pinnata to Inhibit Neuronal Apoptosis after Ischemic Stroke via NMDAR and Caspase-3

Shodiq

Hartono

Khaerunnisa

et al. 2023

AKSONA

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Highlight: The potential of Pongamia pinnata as an inhibitor of apoptosis in ischemic stroke has never been evaluated before. Pongamia pinnata has potential to inhibit neuronal apoptosis via NMDAR and Caspase-3 in ischemic stroke. Karanjachromene has the best binding interaction to inhibit NMDAR. ABSTRACT Introduction: One of the cardiovascular diseases with the highest mortality rate is stroke. Stroke is the second-leading cause of death worldwide. Each year, 12.2 million new cases of stroke occur, of which 7.6 million are ischemic strokes. In ischemic stroke, there are several pathways that cause neuronal apoptosis. The activity of NMDAR and caspase-3 is one of the pathways. Pongamia pinnata phytochemicals have a neuroprotective function against neurological disorders. However, its use as an inhibitor of apoptosis in ischemic stroke has never been evaluated before. Objective: This research was designed to evaluate the phytochemicals of Pongamia pinnata as inhibitors of neuronal apoptosis in ischemic stroke using an in silico study. Methods: This study used four main phytochemicals of Pongamia pinnata, namely Karanjin, Karanjachromene, Pongapin, and Pongachromene. The protein targets for neuronal apoptosis were NMDAR and caspase-3. The molecular docking processes were ligand preparation, protein preparation, grid box determination, molecular docking, and visualized molecular docking. Results: In silico results showed that at NMDAR target proteins, Karanjin, Karanjachromene, Pongapin, and Pongachromene have binding energies of -5.12, -5.83, -5.03, and -5.13 kcal/mol. At protein targets, Caspase-3, Karanjin, Karanjachromene, Pongapin, and Pongachromene have binding energies of -4.87, -4.98, -4.88, and -5.08 kcal/mol. Conclusion: The phytochemicals of Pongamia pinnata have the potential to inhibit neuronal apoptosis via NMDAR and caspase-3 in ischemic stroke. The binding of Karanjachromene to NMDAR demonstrated the compound's best interaction.

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Section: Introductionmentioning

confidence: 99%

In Silico Analysis of Pongamia pinnata to Inhibit Neuronal Apoptosis after Ischemic Stroke via NMDAR and Caspase-3

Shodiq

Hartono

Khaerunnisa

et al. 2023

AKSONA

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Exploring the therapeutic potential of Pongamia pinnata plant extract against skin cancer: In-silico and in-vitro study

Navyatha Karamala,

Karthik,

Raghu

et al. 2025

Journal of Ethnopharmacology

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Therapeutic Importance and Pharmacological Activities of Karanjin in the Medicine for the Treatment of Human Disorders: A Review through Scientific Data Analysis

Patel

2022

CDTH

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Backgrounds: Plant and derived herbal drugs have been used in the traditional system of medicine for the treatment of various forms of human health complications since a very early age. Commercial products prepared from natural herbs have been always valuable for the society in the form of health supplement to medicament. In the ancient time, herbal products were mainly prepared from plants and their derived phytochemical. Plants contain a rich source of pure phytochemical called secondary metabolite and examples are flavonoids, glycosides, tannins and terpenoids etc. Plants and their parts including fruits, flowers, vegetables etc. are the best source of Flavonoid class phytochemicals. Methods: Present work summarized the scientific information of karanjin for their health beneficial aspects and pharmacological activities including its analytical aspects. In the present investigation, scientific data of karanjin have been collected from various scientific databases such as Google, Goggle Scholar, Science Direct and PubMed and analyzed to know the health beneficial aspects of karanjin in the medicine. Further pharmacological activity data has been collected and analyzed in the present work to know their biological potential in the medicine. Analytical methods used for the separation, isolation, and identification of karanjin for the standardization of different natural products have been also discussed in the present work. Results: Scientific data analysis signified the biological importance of Flavonoid class phytochemicals in the medicine as they are well known for their anti-ischemic, vasodilatory, anti-bacterial, anti-inflammatory, anti-oxidant, anti-viral, and anti-cancer activities. Scientific data analysis revealed the presences of karanjin in numerous medicinal plants such as Fordia cauliflora, Lonchocarpus latifolius, Millettia pinnata, Millettia pubinervis, Pongamia pinnata, and Tephrosia purpurea. Pharmacological activity data revealed the biological potential of karanjin against cancerous disorders, glucose metabolism abnormalities, gastrointestinal disorders, arthritis, inflammatory disorders, colitis, psoriasis and brain related disorders. However, analytical data signified the importance of RP-HPLC, TLC, HPTLC, UPLC-ESI-MS/MS and HSCCC techniques in the medicine for the quantification of karanjin in different samples. Conclusion: Presented information about karanjin in this review paper will be beneficial to the scientific peoples of the world to know the health beneficial aspects of karanjin in the medicine.

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In silico analysis of new flavonoids from Pongamia pinnata with a therapeutic potential for age-related macular degeneration

Cited by 3 publications

References 17 publications

In Silico Analysis of Pongamia pinnata to Inhibit Neuronal Apoptosis after Ischemic Stroke via NMDAR and Caspase-3

In Silico Analysis of Pongamia pinnata to Inhibit Neuronal Apoptosis after Ischemic Stroke via NMDAR and Caspase-3

Exploring the therapeutic potential of Pongamia pinnata plant extract against skin cancer: In-silico and in-vitro study

Therapeutic Importance and Pharmacological Activities of Karanjin in the Medicine for the Treatment of Human Disorders: A Review through Scientific Data Analysis

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