In silico anti-preeclampsia potential of phytochemical found in Ficus elastica

Ginting, Chrismis Novalinda; Lister, I Nyoman Ehrich; Girsang, Ermi; Putri, Yolanda Eliza; Mutia, Maya Sari; Purba, Riastawaty; Widowati, Wahyu; Wibowo, Satrio Haryo Benowo; Rizal, Rizal

doi:10.4103/pr.pr_176_18

Cited by 3 publications

(5 citation statements)

References 14 publications

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“…Our results show that FEE can reduce pro-inflammatory TNF-α and increase proinflammatory IL-10 in PE cells model. Previous studies by Ginting et al [11,35] found that FEE contains flavonoid compounds, including quercitrin and myricitrin. These flavonoids belong to the polyphenol group and have an important anti-inflammatory effect by influencing cytokine secretion.…”

Section: Discussionmentioning

confidence: 93%

“…During PE, placental inflammation and chronic peripheral vascular Treatments conditions lead to further complications in the pregnancy [29]. F. elastica is beneficial for treating PE due to antioxidant and anti-inflammatory activities and inhibition of beta-adrenergic receptor 2 (ADRB2) [11]. In another study, the methanolic extract of F. elastica also had anti-inflammatory activities through inhibition of 15-lipoxygenase (15-LOX) with an IC50 value of 3.47 ± 0.07 µg/mL compared to quercetin (IC50 = 24.60 ± 0.07 µg/mL).…”

Section: Discussionmentioning

confidence: 99%

“…These flavonoids belong to the polyphenol group and have an important anti-inflammatory effect by influencing cytokine secretion. Quercitrin in the F. elastica extract was able to inhibit pro-inflammatory cytokines like TNF-α and increased the IL-10 cytokine level [11]. Based on Ginting et al [36], in hypoxia-induced endothelial cells as a preeclampsia model, quercitrin had antioxidant and anti-inflammatory effects that could reduce the percentage of apoptotic cells, inhibit FGF2 and MDA levels, and enhance the percentage of viable cells.…”

Section: Discussionmentioning

confidence: 99%

“…Several plants have been extensively studied in different countries and found to have antihypertensive properties. A previous study found that Ficus elastica leaf contains various compounds, such as flavonoid quercetin and myricitrin [11]. Flavonoid compounds are able to decreased the TNF-α level by in vitro, in vivo, and clinical studies [12].…”

Section: Introductionmentioning

confidence: 97%

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Ficus elastica Leaf Extract Effect Toward IL-10 and TNF-α as a Preeclampsia Model on Hypoxia-induced EA.hy926

Ginting

Lister

Girsang

et al. 2022

J. Math. Fund. Sci.

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Preeclampsia is a pregnancy complication characterized by proteinuria, hypertension, hypoxia as well an increased systemic inflammatory response. It affects 5 to 10% of all births and is a leading factor in fetal and maternal morbidity and death. Ficus elastica L. leaves are known to have natural compounds with anti-inflammatory and antioxidant properties. This research assessed the potential of F. elastica leaf extract (FEE) as anti-inflammatory agent in a hypoxic-induced human endothelial cell line (EA.hy926) as preeclampsia model. F. elastica leaves were extracted using 70% ethanol. Cytotoxic assay of the FEE in different concentrations (3.13 to 100 µg/ml) against EA.hy926 was done using MTS assay. The FEE’s anti-inflammatory activity was measured with ELISA for the TNF-α and IL-10 parameters. The FEE did not cause cytotoxicity to the EA.hy926 cells, with viability above 80% at the highest concentration. The FEE could decrease the pro-inflammatory TNF-α level and increase the IL-10 level as anti-inflammatory markers in the preeclampsia model at significance level p < 0.05. This study suggests that FEE is a safe alternative herbal medicine for preeclampsia treatment.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Ficus elastica Leaf Extract Effect Toward IL-10 and TNF-α as a Preeclampsia Model on Hypoxia-induced EA.hy926

Ginting

Lister

Girsang

et al. 2022

J. Math. Fund. Sci.

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“…Due to its affinity and intermolecular interactions, morin can occupy ADRB2 ligand binding pocket, which can reduce its activity. This indicated that morin can be further developed as an antihypertensive agent through ADRB2 receptor inhibition (87). In addition, the ethanol extract of F. elastica leaves can suppress tumor necrosis factoralpha and increase interleuikin-10 levels in EA.hy926 cells without causing cytotoxic effects.…”

Section: Anti-preeclampsia Activitymentioning

confidence: 98%

Phytochemistry, traditional uses, and pharmacological activities of Ficus elastica Roxb. ex Hornem: A review

Arsyad

Nurrochmad

Fakhrudin

2022

J Herbmed Pharmacol

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Ficus elastica Roxb. ex Hornem is usually found in tropical and subtropical areas, used in traditional medicine for various health problems, including pain, rheumatism, diarrhea, hypertension, infection, skin allergies, anemia, wound, hernia, and hemorrhoids. This review aims to present the phytoconstituents and pharmacological activities of F. elastica. A literature search employing PubMed, Google Scholar, Semantic Scholar, and Library was done to retrieve the relevant articles. F. elastica is a good source of traditional medicine for the treatment of various types of diseases, especially for microbial infections and preeclampsia. Quercitrin and myricetrin, having strong antioxidant activity, as well as ficusamide, ficusoside B, elastiquinone, elasticoside, and elasticamide are compounds, which have potential to be developed as new drugs for these conditions. In sum, the data regarding the pharmacological and safety aspects of this plant and its components are still limited. However, F. elastica is a natural product that has beneficial to human health and might be a good source for the preparation of new drugs.

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Apoptotic, MDA, and FGF2 level of quercitrin treatment on hypoxic-induced EA.hy926 Cell Line

et al. 2021

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In silico anti-preeclampsia potential of phytochemical found in Ficus elastica

Cited by 3 publications

References 14 publications

Ficus elastica Leaf Extract Effect Toward IL-10 and TNF-α as a Preeclampsia Model on Hypoxia-induced EA.hy926

Ficus elastica Leaf Extract Effect Toward IL-10 and TNF-α as a Preeclampsia Model on Hypoxia-induced EA.hy926

Phytochemistry, traditional uses, and pharmacological activities of Ficus elastica Roxb. ex Hornem: A review

Apoptotic, MDA, and FGF2 level of quercitrin treatment on hypoxic-induced EA.hy926 Cell Line

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