In-situ forming hydrogel incorporated with reactive oxygen species responsive and antibacterial properties for diabetic infected chronic wound healing

Recent advances in responsive hydrogels for diabetic wound healing

“…In vivo experiments indicate that DPE2 has an excellent antibacterial effect and significant anti-inflammatory activity and can promote collagen deposition. These results indicated the important role of DPE2 hydrogels in promoting infected diabetic wound healing [ 208 ].…”

Glycopolymer-based multifunctional antibacterial hydrogel dressings for accelerating cutaneous wound healing

“…Antibacterial hydrogels could serve as an effective protective barrier to prevent bacterial infection, and their good antibacterial properties are very essential for wounding healing. 43 Thus, in this study, Gram-negative bacteria ( E. coli ) and Gram-positive bacteria ( S. aureus ) were selected as the model bacteria to investigate the antibacterial abilities of different hydrogels. Images of colony forming units (CFUs) in the agar plates after 24 h incubation are presented in Fig.…”

“…Antibacterial hydrogels could serve as an effective protective barrier to prevent bacterial infection, and their good antibacterial properties are very essential for wounding healing. 43 Fig. 2 Self-healing properties of the PMDL-12%/borax/Ag NPs hydrogels.…”

Cleavage and Noncleavage Chemistry in Reactive Oxygen Species (ROS)-Responsive Materials for Smart Drug Delivery

“…151 Furthermore, antibacterial materials incorporating PBA ester linkers have been designed to react with excessive hydrogen peroxide in the wound microenvironment, promoting accelerated wound healing in the inflammatory area. 152 ROS-responsive nanoparticles, modified with PBA esters on dextran, exhibited selective degradation in the presence of hydrogen peroxide and enabled controlled release of encapsulated drugs for the treatment of inflammatory bowel disease. 153 In the field of gene therapy, Shen's group developed an ROS-liable charge-reversal polymeric nanoparticle.…”