In situ microemulsion-gel obtained from bioadhesive hydroxypropyl methylcellulose films for transdermal administration of zidovudine

Cavalcanti, Sócrates Cabral de Holanda; Porfírio, Leandro de O.; Silva, Luiz André Santos; Santana, Danielle Gomes; Barbosa, Paula Ferreira; Santos, Cochiran Pereira dos; Narain, Narendra; Sarmento, Víctor Hugo Vitorino; Nunes, Rogéria de Souza; Ting, Elizabeth; Lira, Ana Amélia Moreira

doi:10.1016/j.colsurfb.2019.110739

Cited by 14 publications

(5 citation statements)

References 34 publications

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“…Applications of PE containing cellulose include lipid digestion controller [18], and as carrier for the delivery of bioactive compounds and drugs [19,20]. It has been well described that these cellulosic-material may form a mechanical layer of solids that adsorb both water and oil on their interface, thus stabilize the mixture and prevent coalescence [21][22][23]. Formulation of nano-sized emulsion has been limited.…”

Section: Introductionmentioning

confidence: 99%

Effect of cellulose nanocrystal supplementation on the stability of castor oil microemulsion

Gunarto

Hsu

et al. 2021

Journal of Molecular Liquids

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Section: Introductionmentioning

confidence: 99%

Effect of cellulose nanocrystal supplementation on the stability of castor oil microemulsion

Gunarto

Hsu

et al. 2021

Journal of Molecular Liquids

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“…Droplet size and polydispersion index (PDI) of MEs was measured after dilution of the sample with high-purity water in rates of 1:150 (v:v) using a dynamic light scattering method by Zetasizer Nano-ZS instrument (Malvern Instruments, Worcestershire, United Kingdom) (Souza de Araujo et al, 2020).…”

Section: Dynamic Light Scattering (Dls)mentioning

confidence: 99%

“…The formulations rheological analysis was performed using a Discovery Hybrid Rheometer (DHR-1, TA instruments) as described by (Souza de Araujo et al, 2020). A cone and plate device (50 mm diameter, 1 • cone angle and 200 µm gap) was used for rheological characterization of the MEs.…”

Section: Rheological Measurementsmentioning

confidence: 99%

“…This molecule has a non-toxic nature and has influenced droplet size, size distribution and PDI value (Dai et al, 1997;Ghosh et al, 2014;Pavoni et al, 2020). The mixture of polysorbate 80 and propylene glycol were previously used as surfactants to obtain ME (De Sá et al, 2020;Pumival et al, 2020;Souza de Araujo et al, 2020), mainly in regions with a higher proportion of surfactants. This is interesting as the final product will have a high concentration of surfactant, which will be diluted for application.…”

Section: Phase Behavior Of the Microemulsionmentioning

confidence: 99%

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Incorporation of essential oil from Vitex gardneriana (Lamiaceae) in microemulsions systems based on mineral and cottonseed oils increased its bioactivity against a coconut pest mite

Barreto

Costa

Santos

et al. 2022

Industrial Crops and Products

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“…It was selected as a cosolvent in the preparation of in situ gel formulations of mitiglinide calcium for simultaneous extended delivery and enhanced drug bioavailability [39]. It has also been reported as a co-surfactant of an in situ microemulsion-gel in bio-adhesive hydroxypropyl methylcellulose films for zidovudine transdermal administration [40]. In this study, monopropylene glycol is used to dissolve Eudragit L-and Eudragit S-based ISGs since it is safe and has been used in the pharmaceutical field.…”

Section: Introductionmentioning

confidence: 99%

Levofloxacin HCl-Loaded Eudragit L-Based Solvent Exchange-Induced In Situ Forming Gel Using Monopropylene Glycol as a Solvent for Periodontitis Treatment

Senarat

Tuntarawongsa

Lertsuphotvanit

et al. 2023

Gels

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Solvent exchange-induced in situ forming gel (ISG) is currently an appealing dosage form for periodontitis treatment via localized injection into the periodontal pocket. This study aims to apply Eudragit L and Eudragit S as matrix components of ISG by using monopropylene glycol as a solvent for loading levofloxacin HCl for periodontitis treatment. The influence of Eudragit concentration was investigated in terms of apparent viscosity, rheological behavior, injectability, gel-forming behavior, and mechanical properties. Eudragit L-based formulation presented less viscosity, was easier to inject, and could form more gel than Eudragit S-based ISG. Levofloxacin HCl-loading diminished the viscosity of Eudragit L-based formulation but did not significantly change the gel formation ability. Higher polymer loading increased viscosity, force-work of injectability, and hardness. SEM photographs and µCT images revealed their scaffold formation, which had a denser topographic structure and less porosity attained owing to higher polymer loading and less in vitro degradation. By tracking with fluorescence dyes, the interface interaction study revealed crucial information such as solvent movement ability and matrix formation of ISG. They prolonged the drug release for 14 days with fickian drug diffusion kinetics and increased the release amount above the MIC against test microbes. The 1% levofloxacin HCl and 15% Eudragit L dissolved in monopropylene glycol (LLM15) was a promising ISG because of its appropriate viscosity (3674.54 ± 188.03 cP) with Newtonian flow, acceptable gel formation and injectability (21.08 ± 1.38 N), hardness (33.81 ± 2.3 N) and prolonged drug release with efficient antimicrobial activities against S. aureus (ATCC 6538, 6532, and 25923), methicillin-resistant S. aureus (MRSA) (S. aureus ATCC 4430), E. coli ATCC 8739, C. albicans ATCC 10231, P. gingivalis ATCC 33277, and A. actinomycetemcomitans ATCC 29522; thus, it is the potential ISG formulation for periodontitis treatment by localized periodontal pocket injection.

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In situ microemulsion-gel obtained from bioadhesive hydroxypropyl methylcellulose films for transdermal administration of zidovudine

Cited by 14 publications

References 34 publications

Effect of cellulose nanocrystal supplementation on the stability of castor oil microemulsion

Effect of cellulose nanocrystal supplementation on the stability of castor oil microemulsion

Incorporation of essential oil from Vitex gardneriana (Lamiaceae) in microemulsions systems based on mineral and cottonseed oils increased its bioactivity against a coconut pest mite

Levofloxacin HCl-Loaded Eudragit L-Based Solvent Exchange-Induced In Situ Forming Gel Using Monopropylene Glycol as a Solvent for Periodontitis Treatment

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