In situ surface modification on dental composite resin using 2-methacryloyloxyethyl phosphorylcholine polymer for controlling plaque formation

Koyama, Jun; Fukazawa, Kyoko; Ishihara, Kazuhíko; Mori, Yoshiyuki

doi:10.1016/j.msec.2019.109916

Cited by 22 publications

(16 citation statements)

References 35 publications

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“…As previously reported, the hydrophilic nature and water-compatible characteristics of the MPC polymer coating contribute to the reduction of bacterial adhesion on the new lens surface. 15 , 25 , 61 …”

Section: Resultsmentioning

confidence: 99%

Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface

et al. 2021

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Inspired by the cell membrane surface as well as the ocular tissue, a novel and clinically applicable antifouling silicone hydrogel contact lens material was developed. The unique chemical and biological features on the surface on a silicone hydrogel base substrate were achieved by a cross-linked polymer layer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), which was considered important for optimal on-eye performance. The effects of the polymer layer on adsorption of biomolecules, such as lipid and proteins, and adhesion of cells and bacteria were evaluated and compared with several conventional silicone hydrogel contact lens materials. The MPC polymer layer provided significant resistance to lipid deposition as visually demonstrated by the three-dimensional confocal images of whole contact lenses. Also, fibroblast cell adhesion was decreased to a 1% level compared with that on the conventional silicone hydrogel contact lenses. The movement of the cells on the surface of the MPC polymer-modified lens material was greater compared with other silicone hydrogel contact lenses indicating that lubrication of the contact lenses on ocular tissue might be improved. The superior hydrophilic nature of the MPC polymer layer provides improved surface properties compared to the underlying silicone hydrogel base substrate.

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Section: Resultsmentioning

confidence: 99%

Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface

et al. 2021

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“…To prevent salivary protein coating on the resin surface from interfering with the action of non-releasable antimicrobial agents, protein-repellent agents have been introduced [ 92 , 93 ]. Earlier, Muller et al discovered that poly(ethylene glycol) and methacrylate monomers with pyridinium groups were immobilized to produce protein-repellent functions [ 92 ].…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

“…Koyama et al synthesized a MPC polymer that could bind on the surfaces of the resin composite in situ. The modified surface showed obvious resistance to oral protein adsorption and bacterial adhesion, even when the surface was brushed with a toothbrush [ 93 ]. Fujiwara et al conducted a single-blind crossover clinical trial to evaluate the effect of 5% MPC polymer mouthwash after 5 h on oral microflora.…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Sun¹,

Zhang²,

Bai³

et al. 2021

Polymers

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Repairing tooth defects with dental resin composites is currently the most commonly used method due to their tooth-colored esthetics and photocuring properties. However, the higher than desirable failure rate and moderate service life are the biggest challenges the composites currently face. Secondary caries is one of the most common reasons leading to repair failure. Therefore, many attempts have been carried out on the development of a new generation of antimicrobial and therapeutic dental polymer composite materials to inhibit dental caries and prolong the lifespan of restorations. These new antimicrobial materials can inhibit the formation of biofilms, reduce acid production from bacteria and the occurrence of secondary caries. These results are encouraging and open the doors to future clinical studies on the therapeutic value of antimicrobial dental resin-based restoratives. However, antimicrobial resins still face challenges such as biocompatibility, drug resistance and uncontrolled release of antimicrobial agents. In the future, we should focus on the development of more efficient, durable and smart antimicrobial dental resins. This article focuses on the most recent 5 years of research, reviews the current antimicrobial strategies of composite resins, and introduces representative antimicrobial agents and their antimicrobial mechanisms.

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“…They found that only a low concentration of MPC, about 3 wt.%, would be effective to reach their targets. Koyama et al [ 48 ] utilized MPC to modify a dental resin composite for controlling plaque formation. The chemical binding of MPC to the surface of resin composite through visible-light irradiation was achievable, and the DC% could reach 55–75%, meeting the requirement.…”

Section: Curing Behavior and Mechanical Propertiesmentioning

confidence: 99%

Application of Antimicrobial Polymers in the Development of Dental Resin Composite

et al. 2020

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Dental resin composites have been widely used in a variety of direct and indirect dental restorations due to their aesthetic properties compared to amalgams and similar metals. Despite the fact that dental resin composites can contribute similar mechanical properties, they are more likely to have microbial accumulations leading to secondary caries. Therefore, the effective and long-lasting antimicrobial properties of dental resin composites are of great significance to their clinical applications. The approaches of ascribing antimicrobial properties to the resin composites may be divided into two types: The filler-type and the resin-type. In this review, the resin-type approaches were highlighted. Focusing on the antimicrobial polymers used in dental resin composites, their chemical structures, mechanical properties, antimicrobial effectiveness, releasing profile, and biocompatibility were included, and challenges, as well as future perspectives, were also discussed.

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In situ surface modification on dental composite resin using 2-methacryloyloxyethyl phosphorylcholine polymer for controlling plaque formation

Cited by 22 publications

References 35 publications

Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface

Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Application of Antimicrobial Polymers in the Development of Dental Resin Composite

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