In utero exposure to triphenyltin disrupts rat fetal testis development

Ge, Fei; Zheng, Wenwen; Bao, Suhao; Wu, Keyang; Xiang, Saiqiong; Chen, Wanwan; Chen, Xiuxiu; Mo, Jiaying; Zhou, Songyi; Wang, Yiyan; Lian, Qingquan

doi:10.1016/j.chemosphere.2018.08.016

Cited by 20 publications

(1 citation statement)

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“…Earlier investigations have delved into the male reproductive toxicity of this compound, and it was reported that by disturbing the microenvironments of Leydig and Sertoli cells, TPT diminishes the proliferative potential of spermatogonia, leading to the production of subpar sperm in adult male rats [66]. Furthermore, exposure to TPT during pregnancy exerts an impact on the development of the fetal testis in rats, resulting in a dose-dependent reduction in serum testosterone levels, the induction of fetal Leydig cell aggregation, and a decrease in the size of the fetal Leydig cells [67]. TBT, an artificial organic derivative of tin, exhibits a chemical structure in which covalent bonds are formed between carbon and tin atoms.…”

Section: Male Reproductive Effects Of Antifouling Agentsmentioning

confidence: 99%

Male Reproductive Toxicity of Antifouling Chemicals: Insights into Oxidative Stress-Induced Infertility and Molecular Mechanisms of Zinc Pyrithione (ZPT)

Panga,

Zhao

2024

Antioxidants

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Zinc pyrithione (ZPT), a widely utilized industrial chemical, is recognized for its versatile properties, including antimicrobial, antibacterial, antifungal, and antifouling activities. Despite its widespread use, recent research has shed light on its toxicity, particularly towards the male reproductive system. While investigations into ZPT’s impact on male reproduction have been conducted, most of the attention has been directed towards marine organisms. Notably, ZPT has been identified as a catalyst for oxidative stress, contributing to various indicators of male infertility, such as a reduced sperm count, impaired sperm motility, diminished testosterone levels, apoptosis, and degenerative changes in the testicular tissue. Furthermore, discussions surrounding ZPT’s effects on DNA and cellular structures have emerged. Despite the abundance of information regarding reproductive toxicity, the molecular mechanisms underlying ZPT’s detrimental effects on the male reproductive system remain poorly understood. This review focuses specifically on ZPT, delving into its reported toxicity on male reproduction, while also addressing the broader context by discussing other antifouling chemicals, and emphasizing the need for further exploration into its molecular mechanisms.

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Section: Male Reproductive Effects Of Antifouling Agentsmentioning

confidence: 99%