In vitro activities of antimicrobial peptides and ceragenins against Legionella pneumophila

Birteksöz-Tan, Ayşe Seher; Zeybek, Zuhal; Hacıoğlu, Mayram; Savage, Paul B.; Bozkurt-Guzel, Cagla

doi:10.1038/s41429-019-0148-1

Cited by 15 publications

(10 citation statements)

References 34 publications

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“…MIC values were compared with various conventional antibiotics, and overall CSA-13 was the most effective with an MIC range 1–2 µg/ml [69]. A recent study indicated that the spectrum of antimicrobial activity of ceragenins includes Legionella pneumophila , using CSA-8, CSA-13, CSA-44, CSA-131 and CSA-138 [70]. Ceragenins were also recorded to be highly effective against Bacillus subtilis spores [71].…”

Section: Antimicrobial Activity Of Nanosystems Functionalized By Ll-3mentioning

confidence: 99%

Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications

et al. 2020

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Nanotechnology-based therapeutic approaches have attracted attention of scientists, in particular due to the special features of nanomaterials, such as adequate biocompatibility, ability to improve therapeutic efficiency of incorporated drugs and to limit their adverse effects. Among a variety of reported nanomaterials for biomedical applications, metal and metal oxide-based nanoparticles offer unique physicochemical properties allowing their use in combination with conventional antimicrobials and as magnetic field-controlled drug delivery nanocarriers. An ever-growing number of studies demonstrate that by combining magnetic nanoparticles with membrane-active, natural human cathelicidin-derived LL-37 peptide, and its synthetic mimics such as ceragenins, innovative nanoagents might be developed. Between others, they demonstrate high clinical potential as antimicrobial, anti-cancer, immunomodulatory and regenerative agents. Due to continuous research, knowledge on pleiotropic character of natural antibacterial peptides and their mimics is growing, and it is justifying to stay that the therapeutic potential of nanosystems containing membrane active compounds has not been exhausted yet.

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Section: Antimicrobial Activity Of Nanosystems Functionalized By Ll-3mentioning

confidence: 99%

Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications

et al. 2020

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“…As it was mentioned above (Section 3.11), ceragenins are positively charged polyamine derivatives of cholic acids that electrostatically interact with negatively charged phospholipids of bacteria, viruses, fungi, and protozoa and lead to an increase in fluidity, depolarization, and permeabilization of their membranes, which inhibits infectivity or results in bacteria death. Multi-resistant strains of bacteria that are susceptible to ceragenins include S. aureus, S. pneumoniae, S. pyogenes, H. influenza, P. aeruginosa, N. meningitides, L. pneumophila etc., Candida, C. neoformans, and A. fumigatus fungi, trypanosomes, as well as the vaccinia virus in 5 µM concentration [222][223][224].…”

Section: Ceragenins As Antibioticsmentioning

confidence: 99%

“…that are susceptible to ceragenins include S. aureus, S. pneumoniae, S. pyogenes, H. influenza, P. aeruginosa, N. meningitides, L. pneumophila etc., Candida, C. neoformans, and A. fumigatus fungi, trypanosomes, as well as the vaccinia virus in 5 μM concentration [222][223][224].…”

Section: Ceragenins As Antibioticsmentioning

confidence: 99%

From Marine Metabolites to the Drugs of the Future: Squalamine, Trodusquemine, Their Steroid and Triterpene Analogues

Казакова

Giniyatullina

Babkov

et al. 2022

IJMS

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This review comprehensively describes the recent advances in the synthesis and pharmacological evaluation of steroid polyamines squalamine, trodusquemine, ceragenins, claramine, and their diverse analogs and derivatives, with a special focus on their complete synthesis from cholic acids, as well as an antibacterial and antiviral, neuroprotective, antiangiogenic, antitumor, antiobesity and weight-loss activity, antiatherogenic, regenerative, and anxiolytic properties. Trodusquemine is the most-studied small-molecule allosteric PTP1B inhibitor. The discovery of squalamine as the first representative of a previously unknown class of natural antibiotics of animal origin stimulated extensive research of terpenoids (especially triterpenoids) comprising polyamine fragments. During the last decade, this new class of biologically active semisynthetic natural product derivatives demonstrated the possibility to form supramolecular networks, which opens up many possibilities for the use of such structures for drug delivery systems in serum or other body fluids.

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“…The plates were incubated for 24 h at 37°C. After incubation, the wells were washed twice with PBS and were measured spectrophotometrically at 450 nm, on a microplate reader (BioRad Novapath) [8,17]. Cell culture and plant extracts treatment For revealing of anticarcinogenic effects of Arum extracts on breast cancer, HUVECs and MDA-MB-231 cell lines were obtained from the American Type Culture Collection (Virginia, USA).…”

Section: Biofilm Attachment Assaymentioning

confidence: 99%

In vitro activities of antimicrobial peptides and ceragenins against Legionella pneumophila

Cited by 15 publications

References 34 publications

Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications

Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications

From Marine Metabolites to the Drugs of the Future: Squalamine, Trodusquemine, Their Steroid and Triterpene Analogues

In Vitro Antimicrobial, Antibiofilm and Cytotoxic Activities of the Extracts of Arum Italicum Miller Leaves

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