In Vitro Activity of Colistin against Multidrug-Resistant Gram-Negative Bacteria Isolated at a Major Army Hospital during the Military Campaigns in Iraq and Afghanistan

Paolino, Kris; Erwin, Daniel P.; Padharia, Vanaja; Carrero, Hector; Giron, Lizzette; Burgess, Robert; Burger, Chad; Martínez, María José Fresnadillo; Arrieta, Patricia; Wortmann, Glenn; Zapor, Michael

doi:10.1086/518710

Cited by 10 publications

(7 citation statements)

References 2 publications

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“…4 However, Hawley et al reported a resistance rate of 37% against imipenem for Acinetobacter isolates from deployed US military personnel. 5 In accordance with other reports 6 we also observed good in vitro activity by colistin against A. baumannii and Ps. aeruginosa.…”

supporting

confidence: 92%

Multidrug resistant bacteria in wounds of combatants of the Libyan uprising

Franka

Shembesh

Zaied³

et al. 2012

Journal of Infection

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supporting

confidence: 92%

Multidrug resistant bacteria in wounds of combatants of the Libyan uprising

Franka

Shembesh

Zaied³

et al. 2012

Journal of Infection

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“…Colistin, developed in the 1950s, has shown new utility against Gram-negative organisms in the 21st century [16,31,33,36,39], and may be useful in treating ABC [44]. Also, new antibiotics may soon prove their usefulness against MDROs.…”

Section: Discussionmentioning

confidence: 99%

Multidrug-resistant Organisms in Military Wounds from Iraq and Afghanistan

Calhoun

Murray

Manring

2008

Clinical Orthopaedics &Amp; Related Research

161

136

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Mortality from battlefield wounds has historically declined, thanks to better surgical management, faster transport of casualties, and improved antibiotics. Today, one of the major challenges facing U.S. military caregivers is the presence of multidrug-resistant organisms in orthopaedic extremity wounds. The most frequently identified resistant strains of bacteria are Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter calcoaceticus-baumannii complex. Overuse of broad-spectrum antibiotics may be an important factor in building resistant strains. Acinetobacter infections appear to hospital-acquired and not from an initial colonization of the injury. More research is required to give military physicians the tools they require to reduce the infection rate and defeat multidrug-resistant organisms.

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“…Most studies examining K. pneumoniae reported very high polymyxin susceptibility rates, approaching ϳ90% to 95% (18,23,24,54,94,127,138,167). Susceptibility has been noted to be lower in multidrug-resistant isolates, including carbapenemase-producing strains (4,18,23).…”

Section: Susceptibility Reportsmentioning

confidence: 99%

“…Substantial variation was seen in reports concerning S. maltophilia (54,55,73,127,130) and Enterobacter spp. (23,24,54,94,138,167), with susceptibility rates ranging from 28% to 77% and 79% to 97%, respectively. The reasons for this variability are unclear; however, the variable susceptibility underscores the need for accurate susceptibility testing to guide treatment decisions.…”

Section: Susceptibility Reportsmentioning

confidence: 99%

Polymyxins Revisited

et al. 2008

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SUMMARY The global emergence of multidrug-resistant gram-negative bacilli has spurred a renewed interest in polymyxins. Once discarded due to concerns regarding nephrotoxicity and neurotoxicity, polymyxins now hold an important role in the antibiotic armamentarium. However, more reliable information is needed to determine the optimal dosing of these agents. Also, unanswered questions regarding in vitro testing remain, including questions regarding the reliability of automated systems and the establishment of appropriate breakpoints for defining susceptibility. Most contemporary clinical studies examining the use of these agents have involved patients with infections due to multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii strains. It has been reassuring that polymyxin therapy for resistant bacteria has resulted in clinical responses and toxicity rates similar to those for carbapenem therapy for susceptible isolates. While most surveillance studies demonstrated high rates of susceptibility, several reports noted the emergence of polymyxin-resistant nosocomial pathogens. Polymyxins have assumed an important antibiotic niche for therapy for hospital-acquired infections; further studies defining the optimal use of these agents will likely extend the duration of their clinical usefulness.

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In Vitro Activity of Colistin against Multidrug-Resistant Gram-Negative Bacteria Isolated at a Major Army Hospital during the Military Campaigns in Iraq and Afghanistan

Cited by 10 publications

References 2 publications

Multidrug resistant bacteria in wounds of combatants of the Libyan uprising

Multidrug resistant bacteria in wounds of combatants of the Libyan uprising

Multidrug-resistant Organisms in Military Wounds from Iraq and Afghanistan

Polymyxins Revisited

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