In vitro activity of daptomycin against multidrug-resistant Staphylococcus aureus and S. aureus with known virulence factors, including community-acquired methicillin-resistant isolates

Validated high performance liquid chromatography–UV detection method for the determination of daptomycin in human plasma

“…The outcome of a therapy with daptomycin in clinical practice is comparable with standard antibiotic treatment [3]. However, daptomycin shows additional activity against multi-resistant bacterial strains like methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci or penicillin-resistant Streptococcus pneumoniae [4] and it is therefore a viable alternative for the treatment of persisting infections [5]. Because of its efficacy and safety in a variety of infectious conditions, this is especially true in critical care settings [6].…”