In vitro and In vivo toxicity assessment of phytofabricated ZnO nanoparticles showing bacteriostatic effect and larvicidal efficacy against Culex quinquefasciatus

Yazhiniprabha, Mariappan; Vaseeharan, Baskaralingam; Sonawane, Avinash; Behera, Ananyaashree

doi:10.1016/j.jphotobiol.2019.01.014

Cited by 35 publications

(13 citation statements)

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“…aegypti is 04.67, 22.95, 0.98, 22.68 at 48 h respectively. In previous study, Yaziniprabha et al [ 9 ] reported that ZnO-NPs using Murraya koenigii were showed significant larvicidal activity against Cx. quinquefasciatus larvae with LC 50 and LC 90 value is 2.1 and 12.1 μg/mL.…”

Section: Resultsmentioning

confidence: 99%

“…The green synthesis method are more advantageous when compare to physical and chemical methods because of their eco-friendly, low cost, increase economic and large-scale synthesis. ZnO nanoparticles have been effectively orchestrated utilizing plants such as, Musa ornate and Zea mays [ 6 ], Drosophila melanogaster [ 7 ], Lycopersicon esculentum [ 8 ] and Murraya koenigii [ 9 ]. Medicinal plants have a rich source of secondary metabolites and also folkloric sacred texts reports a large number of medicinal plants for different therapeutic applications.…”

Section: Introductionmentioning

confidence: 99%

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Metal oxide nanoparticle synthesis (ZnO-NPs) of Knoxia sumatrensis (Retz.) DC. Aqueous leaf extract and It’s evaluation of their antioxidant, anti-proliferative and larvicidal activities

et al. 2021

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In around the world, mosquito control is considered a most important because of the incapable of synthetic insecticides and the ecological pollution about by them. In this manner, need the eco-friendly insecticides to efficient control the mosquito disease is the need of the hour. We synthesized the eco-friendly of zinc oxide nanoparticles (ZnO-NPs) using the Knoxia sumatrensis aqueous leaf extract ( Ks- ALE) as a reducing and stabilizing agent. The synthesis of ZnO-NPs was confirmed by UV with an absorption peak at 354 nm. ZnO-NPs crystal structure was analyzed by X-ray diffraction (XRD). Fourier transform infrared spectroscopy (FT-IR) spectra revealed the chloride, cyclic alcohols, sulfonamies, carboxylic acids, oximes, phosphines, alkenes and alcohol & phenol. Field emission-scanning electron microscopy (FE-SEM) showed that the NP’s are rod shaped with 50–80 nm size and also energy dispersive spectra (EDaX) spectra showed presence of zinc. Antioxidant assay showed superior activity and evidenced by DPPH, ABTS and H 2 O 2 radical assays. Furthermore, the ZnO-NPs exhibited strong activity in MCF-7 cell line with IC 50 value is 58.87 μg/mL. Mosquito larvicidal activity of ZnO-NPs produced significant activity and excellent larvicidal activity was noticed in Cx. quinquefasciatus with LC 50 0.08, mg/mL and LC 90 19.46 mg/mL. This study suggests that synthesized ZnO-NPs using Knoxia sumatrensis leaf extract have good biological activities and it makes them an ideal candidate for pharmacological studies.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metal oxide nanoparticle synthesis (ZnO-NPs) of Knoxia sumatrensis (Retz.) DC. Aqueous leaf extract and It’s evaluation of their antioxidant, anti-proliferative and larvicidal activities

et al. 2021

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“…It is hypothetically suggested that the mechanism of toxicity against mosquito larvae by the penetration of nanoparticles through the exoskeleton. In intracellular space, nanoparticle degrades the enzymes and organelles, and it leads to the loss of cellular function and cell death [31,32]. The AgNPs from Artemisia vulgaris leaf extracts showed the mosquito larvicidal activity.…”

Section: Resultsmentioning

confidence: 99%

Biogenic Synthesis of Silver Chloride Nanoparticles from Padina gymnospora and their Evaluation of Antimicrobial, Larvicidal, Hemolytic and Anticancer Activities.

Rajagopal¹,

Manivannan

Sundararajan

et al. 2020

Preprint

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In the current study, silver chloride nanoparticles (AgClNPs) have been synthesized using the aqueous extract of Padina gymnospora and further characterized by Uv-visible spectroscopy, Fourier-transform infrared spectroscopy, X-ray powder diffraction, Scanning electron microscopy, energy dispersive spectroscopy, Transmission electron microscopy and Atomic force microscopy. The synthesized silver chloride nanoparticles were found to be mono-dispersed and spherical with an average size between 11.5 to 32.86 nm. The particles also showed a cytotoxic effect in a dose-dependent manner against MCF 7 cells (IC50 = 31.37 µg/mL). Besides, it showed the larvicidal activity against Aedes aegypti at a lower dose (3.92 µg/ml) than that of the aqueous extract (13.01 µg/ml). It also exhibited significant antimicrobial activity against selected bacterial and fungal pathogens. The synthesized silver chloride nanoparticles showed the best minimum inhibitory concentration (MIC) of 8 mg/L in Canadian Albicans, followed by vancomycin resistance Enterococcus feacasli (VREF) 32 mg/L. Furthermore, the toxicity assessment by haemolytic assay revealed that AgClNPs could be safe and also used for further investigation. Therefore, the synthesized silver chloride nanoparticles may be used as a therapeutic agent for breast cancer, antimicrobial agent and also to control the dengue vector as attributed to the presence of bioactive components.

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“…A variety of chemical, physical, and biological methods have been used to decrease the incidence of vector-borne diseases transmitted by mosquitoes [5]. However, the use of chemical insecticides has resulted in mosquitoes becoming resistant to treatment and beneficial non-target animals being harmed [6] Despite this, new nanobiotechnology materials such as selenium nanowires (Cr-SeNWs) [7, 8] and phytofabricated zinc oxide (ZnO) nanoparticles are still being developed [9].…”

Section: Introductionmentioning

confidence: 99%

Isolating and identifying fungi to determine whether their biological properties have the potential to control the population density of mosquitoes

Wasinpiyamongkol

Kanchanaphum

2019

Heliyon

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Mosquitoes transmit diseases such as dengue, chikungunya, Zika, and yellow fever to humans. Biological control methods are required for these insects because they can be environmentally friendlier, safer, and more costeffective than chemical or physical methods currently available. The aim of this research is to identify fungi found in mosquito breeding containers that have the potential to control the population density of mosquitoes. For the identification, water samples were taken from mosquito breeding containers situated in seven districts of Bangkok to obtain pure cultures. Deoxyribonucleic acid (DNA) was extracted from the cultures then sent for sequencing and analyzing. The results show that fourteen strains of fungi were isolated. The most common strain found was Aspergillus spp., which was present in 31 of the 78 fungi samples. The strains Metarhizium anisopliae and Penicilium citrinum were found to be interesting because they may have the potential to act as entomopathogenic fungi. The biological properties of these strains should be further investigated because they could help in the fight against mosquito-borne diseases.

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In vitro and In vivo toxicity assessment of phytofabricated ZnO nanoparticles showing bacteriostatic effect and larvicidal efficacy against Culex quinquefasciatus

Cited by 35 publications

References 59 publications

Metal oxide nanoparticle synthesis (ZnO-NPs) of Knoxia sumatrensis (Retz.) DC. Aqueous leaf extract and It’s evaluation of their antioxidant, anti-proliferative and larvicidal activities

Metal oxide nanoparticle synthesis (ZnO-NPs) of Knoxia sumatrensis (Retz.) DC. Aqueous leaf extract and It’s evaluation of their antioxidant, anti-proliferative and larvicidal activities

Biogenic Synthesis of Silver Chloride Nanoparticles from Padina gymnospora and their Evaluation of Antimicrobial, Larvicidal, Hemolytic and Anticancer Activities.

Isolating and identifying fungi to determine whether their biological properties have the potential to control the population density of mosquitoes

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