In Vitro and in Vivo Antiplasmodial Activity of Cryptolepine and Related Alkaloids from Cryptolepis sanguinolenta

Cimanga, K.; Bruyne, Tess De; Pieters, Luc; Vlietinck, A. J.; Turger, C A

doi:10.1021/np9605246

Cited by 238 publications

(138 citation statements)

References 15 publications

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“…C. sanguinolenta and the indoquinoline alkaloids isolated from it have been shown to be effective against chloroquine-resistant strains of the parasite. 9,10,12 Therefore, although chloroquine resistance was not part of the study, the high cure rate reported would tend to suggest that the tea bag formulation of the root powder of C. sanguinolenta could be used for the treatment of malaria caused by chloroquine-resistant strain of P. falciparum.…”

Section: 28mentioning

confidence: 99%

“…Crude extracts of C. sanguinolenta and their fractions, as well as indoquinoline alkaloids isolated from the plant, have been shown to have activity against Plasmodium falciparum both in vitro and in vivo. [9][10][11][12][13] In addition to studies indicating anti-plasmodial effect, extracts of C. sanguinolenta have been shown to have anti-microbial activity 3,6,[14][15][16][17][18][19][20][21] , to be anti-hyperglycaemic 22,23 and antiinflammatory. 24 A preliminary study of the clinical efficacy of an aqueous extract of C. sanguinolenta as an anti-malarial preparation had been carried out which indicated the efficacy of the extract against falciparum malaria.…”

Section: Introductionmentioning

confidence: 99%

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Clinical efficacy of a tea-bag formulation of Cryptolepis sanguinolenta root in the treatment of acute uncomplicated falciparum malaria

Bugyei¹,

Boye²,

Addy³

2011

Ghana Medical Journal

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SUMMARYObjective: To evaluate the clinical efficacy and safety of a tea bag formulation of the root of C. sanguinolenta Design: This is a prospective descriptive open trial. Setting: Patients were recruited from Korle-Bu, Mamprobi and Dansoman Polyclinics. Subjects: Forty-four subjects with uncomplicated malaria were recruited for the study. Method: Patients presented with clinical symptoms of malaria. Laboratory investigations conducted included malaria parasite counts, haematological indices and biochemical tests which were obtained before, during and after a 5-day treatment period, up to Day 28 posttreatment. All patients in the study were symptomatic with significant parasitaemia. Patients were given one teabag three times a day, that is, morning, noon and night, for five days of treatment. Results: Fifty percent of the patients were cleared of their P. falciparum parasitaemia by 72 hours, and all by Day 7. Presenting symptoms of fever, chills, nausea and vomiting cleared rapidly, all by Day 3, but resolution of haematological and biochemical abnormalities associated with malaria was generally slow, a feature seen in malaria post-treatment. The overall cure rate was 93.5% due to two cases of recrudescence on Days 21 and 28. The laboratory findings did not suggest any toxicity. Conclusion: On the basis of fever clearance and disappearance of parasitaemia by Day 7, the formulation has been shown to be non-toxic and highly effective in the treatment of acute uncomplicated malaria.

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Section: 28mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical efficacy of a tea-bag formulation of Cryptolepis sanguinolenta root in the treatment of acute uncomplicated falciparum malaria

Bugyei¹,

Boye²,

Addy³

2011

Ghana Medical Journal

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“…2,3) Crude extracts from this plant and their fractions, as well as isolated indoloquinoline alkaloids, have been shown to have antibacterial, [4][5][6][7] antihyperglycemic, 8,9) anti-inflammatory 10,11) and antimalarial activities. [12][13][14][15] Phyto-Riker (Gihoc) Pharmaceuticals Ltd. (Accra, Ghana) has developed an herbal preparation (Phyto-laria ® ) from the dried root of C. sanguinolenta for the treatment of malaria. According to clinical studies, this tea-bag formulation of the root powder (2.5 g) has been shown to be highly effective in the treatment of acute uncomplicated malaria, with an overall cure rate of 93.5%.…”

mentioning

confidence: 99%

Membrane Perturbations Induced by New Analogs of Neocryptolepine

Jaromin

Korycińska

Pįętka-Ottlik

et al. 2012

Biological & Pharmaceutical Bulletin

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antihyperglycemic, 8,9) anti-inflammatory 10,11) and antimalarial activities.12-15) Phyto-Riker (Gihoc) Pharmaceuticals Ltd. (Accra, Ghana) has developed an herbal preparation (Phyto-laria ® ) from the dried root of C. sanguinolenta for the treatment of malaria. According to clinical studies, this tea-bag formulation of the root powder (2.5 g) has been shown to be highly effective in the treatment of acute uncomplicated malaria, with an overall cure rate of 93.5%. Moreover, the laboratory findings did not suggest any toxicity. 16)However, indoloquinoline alkaloids are quite a rare group of natural products. This fact caused significant interest for the synthesis of indoloquinoline alkaloid derivatives, because of their potential biomedical and pharmaceutical value. 1,[17][18][19][20][21][22][23][24][25][26][27] Previous studies have indicated that all indolo[2,3-b]-quinolines belonging to the 5H-series possess interesting biological activities, including inhibition of the growth of Gram-positive bacteria and pathogenic fungi, cytotoxicity against KB cells and stimulation of the formation of calf thymus topoisomerase II mediated DNA cleavage. 17) 5,11-Dimethyl-5H-indolo [2,3-b] quinoline (DIMIQ), a benzoiso-α-carboline derivative, is one of the most interesting and active representatives of this group (Fig. 1). DIMIQ displayed strong antibacterial, antimycotic and cytotoxic activity in vitro as well as significant antitumor properties in vivo. 17,28,29) The influence of analogs of indolo [2,3-b] quinolines on cell cycle effects and their cytotoxicity have been extensively studied in vitro against several cell lines of different origin. Additionally, their ability to inhibit topoisomerase II activity was also evaluated. 18,[30][31][32][33] Osiadacz et al. have performed energy calculations for different DIMIQ orientations inside the DNA duplex. The studies have shown that the most preferred intercalation position, characterized by the lowest complex energy, was the parallel orientation of the long DIMIQ axis and the neighbor base-pair axes. 34)Since therapeutic and toxic effects of drugs are strongly influenced by their lipid affinity, the study of interactions with membranes was necessary. It was also of major importance to Regular Article

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“…A presença abundante de derivados antracênicos nos extratos estudados indicou que tais substâncias poderiam ser as responsáveis por tais atividades 7,8 . Em especial a 1,8-diidroxi-antraquinona (1) (Figura 1) foi considerada uma dos constituintes ativos por apresentar atividade antimalárica in vitro 22 , o que confirmou os resultados obtidos por Tona e colaboradores 8 .…”

Section: Principais Propriedades Bio/farmacológicas E Constituição Quunclassified

Aspectos químicos, biológicos e etnofarmacológicos do gênero Cassia

Viegas¹,

Rezende²,

Silva³

et al. 2006

Quím. Nova

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In Vitro and in Vivo Antiplasmodial Activity of Cryptolepine and Related Alkaloids from Cryptolepis sanguinolenta

Cited by 238 publications

References 15 publications

Clinical efficacy of a tea-bag formulation of <i>Cryptolepis sanguinolenta</i> root in the treatment of acute uncomplicated falciparum malaria

Clinical efficacy of a tea-bag formulation of <i>Cryptolepis sanguinolenta</i> root in the treatment of acute uncomplicated falciparum malaria

Membrane Perturbations Induced by New Analogs of Neocryptolepine

Aspectos químicos, biológicos e etnofarmacológicos do gênero Cassia

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