In vitro and In vivo hepatoprotective studies on methanolic extract of aerial parts of Ludwigia hyssopifolia G. Don Exell

Pallerla, Praneetha; Reddy, Y. V. R.; Kumar, Bobbala Ravi

doi:10.4103/pm.pm_85_18

Cited by 8 publications

(10 citation statements)

References 1 publication

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“…The total phenolic content of the fractions of LCME was determined using the Folin-Ciocalteu colorimetric method [3]. The total phenolic content was expressed as Gallic acid equivalents (GAE) in mg per gram of extract.…”

Section: Total Phenolic Contentmentioning

confidence: 99%

“…This reflects the ability of the fractions in preserving the structural integrity and protection of hepatocellular membrane which is attributed to their antioxidant activity. Paracetamol produces sufficient injury to hepatic parenchyma to cause large increase in bilirubin content [13]. Also a decrease in TP, albumin and prothrombin occurs due to the disruption and dissociation of polyribosome on endoplasmic reticulum leading to decrease in protein biosynthesis.…”

Section: Assessment Of Hepatoprotective Activity Of Fractions Of Lcmementioning

confidence: 99%

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Hepatoprotective studies on methanolic extract fractions of Lindernia ciliata and development of qualitative analytical profile for the bioactive extract

Pallerla

Yellu

2019

Clin Phytosci

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Background: The objective of the study is to evaluate the hepatoprotective activity of methanolic extract fractions of Lindernia ciliata (LC) and development of qualitative analytical profile of the bioactive fraction using HPLC fingerprinting analysis. All the fractions of methanolic extract of Lindernia ciliata (LCME) are assessed for their total phenolic, flavonoid contents and in vitro antioxidant properties by using DPPH, superoxide, nitric oxide, hydroxyl radical scavenging activities and reducing power assay. Acute toxicity study was conducted for all the fractions and the two test doses 50 and 100 mg/kg were selected for the hepatoprotective study. Liver damage was induced in different groups of rats by administering 3 g/kg.b.w.p.o. paracetamol and the effect of fractions were tested for hepatoprotective potential by evaluating serum biochemical parameters and histology of liver of rats. The effective fraction was evaluated for its antihepatotoxic activity against D-Galactosamine (400 mg/kg b.w. i.p.) and in vivo antioxidant parameters viz., Glutathione (GSH), Melondialdehyde (MDA) and Catalase (CAT) levels are estimated using liver homogenate. Results: Among all the fractions, butanone fraction of LCME, (BNF-LCME) has shown better hepatoprotective activity and hence it is selected to evaluate the antihepatotoxicity against D-GaIN. The activity of BNF-LCME is well supported in in vitro and in vivo antioxidant studies and may be attributed to flavonoidal, phenolic compounds present in the fraction. Hence, BNF-LCME was subjected to the development of qualitative analytical profile using HPLC finger printing analysis. Conclusions: All the fractions of LCME exhibited significant hepatoprotective activity and BNF-LCME (50 mg/kg) was identified as the most effective fraction.

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Section: Total Phenolic Contentmentioning

confidence: 99%

Section: Assessment Of Hepatoprotective Activity Of Fractions Of Lcmementioning

confidence: 99%

Hepatoprotective studies on methanolic extract fractions of Lindernia ciliata and development of qualitative analytical profile for the bioactive extract

Pallerla

Yellu

2019

Clin Phytosci

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“…Ludwigia L. (family Onagraceae) is an important pantropic genus widely distributed in South and North America and comprises about 82 species of flowering plants [ 3 ]. Several traditional uses including antidiabetic [ 4 ], antioxidant, antimicrobial [ 5 ], antidiarrheal [ 6 ], and anti-inflammatory activity [ 7 ] were reported for Ludwigia species [ 8 ]. Genus Ludwigia was reported for its richness in different phytochemicals such as flavonoids, saponins, phenolic compounds, and triterpenes [ 3 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical investigation of Ludwigia adscendens subsp. diffusa aerial parts in context of its biological activity

et al. 2022

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Ludwigia adscendens subsp. diffusa (Onagraceae), an important aquatic herb widely distributed in the Nile River and canals in Egypt. The goal of the current study is to investigate the phytochemical composition of L. adscendens aerial parts n-butanol and ethyl acetate fractions and screening of its biological activities. Phytochemical investigation of L. adscendens resulted in the isolation and purification of eleven compounds belonging to flavonoids, saponins, triterpenoids, and oligosaccharides, of which one compound was identified as new using different spectroscopic techniques. Compound 2 was identified as a new compound namely, 3-O-[β-D-glucopyranoside (1 → 4) α-L-rhamnopyranoside]-23-O-feruloyl-hederagenin-28-O-[α-L-rhamnopyranoside (1 → 2) β-D-glucopyranoside], along with other 10 well know compounds. Furthermore, antidiabetic, hepatoprotective and cytotoxic activities of n-butanol and ethyl acetate fractions were investigated in vitro, revealing that ethyl acetate fraction was the most active as antidiabetic (IC50 = 62.3 µg/mL), hepatoprotective (IC50 = 80.75 µg/mL), and cytotoxic against human prostate cancer cell line (IC50 = 52.2 µg/mL). Collectively, L. adscendens aerial part is rich with a myriad of phytochemicals with potential health benefits.

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“…Ludwigia is a pantropic genus and comprises about 82 species of aquatic plants, well represented in South and North America Ludwigia species were reported for their and traditional importance and medicinal uses such as antidiabetic, cytotoxic activity, and anti-inflammatory activity . In Egyptian flora, genus Ludwigia is represented by two species, Ludwigia stolonifera (Guill.…”

Section: Introductionmentioning

confidence: 99%

“…4 Ludwigia species were reported for their and traditional importance and medicinal uses such as antidiabetic, 5 cytotoxic activity, 6 and anti-inflammatory activity. 7 In Egyptian flora, genus Ludwigia is represented by two species, Ludwigia stolonifera (Guill. & Perr.)…”

Section: ■ Introductionmentioning

confidence: 99%

Comparative Volatile Profiling of Ludwigia stolonifera Aerial Parts and Roots Using VSE-GC-MS/MS and Screening of Antioxidant and Metal Chelation Activities

et al. 2021

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Ludwigia stolonifera (Guill. & Perr.) P.H.Raven belonging to the family Onagraceae is an important aquatic herbal plant of economic importance in water bioremediation. We explored the compositional heterogeneity in the aroma profile of L. stolonifera aerial parts and roots. Volatile profiling was employed for the first time using volatile solvent extraction (VSE-GC-MS/MS) of both aerial parts and roots. A total of 85 volatiles were identified belonging to eight classes, viz., aliphatic, aromatic, and oxygenated hydrocarbons, monoterpenes, diterpenes, alcohols, acids/esters, and sterols. Aliphatic and aromatic hydrocarbons were found to be the most abundant metabolite groups in both aerial parts and roots. Furthermore, antioxidant and metal chelation activities of aerial parts and roots were investigated, revealing a potent activity as an antioxidant and high metal chelation capacity for heavy metals.

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In vitro and In vivo hepatoprotective studies on methanolic extract of aerial parts of Ludwigia hyssopifolia G. Don Exell

Cited by 8 publications

References 1 publication

Hepatoprotective studies on methanolic extract fractions of Lindernia ciliata and development of qualitative analytical profile for the bioactive extract

Hepatoprotective studies on methanolic extract fractions of Lindernia ciliata and development of qualitative analytical profile for the bioactive extract

Phytochemical investigation of Ludwigia adscendens subsp. diffusa aerial parts in context of its biological activity

Comparative Volatile Profiling of Ludwigia stolonifera Aerial Parts and Roots Using VSE-GC-MS/MS and Screening of Antioxidant and Metal Chelation Activities

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