In vitro and in vivo anticandidal efficacy of green synthesized gold nanoparticles using Spirulina maxima polysaccharide

Dananjaya, S.H.S.; Thảo, Nguyễn Tiến; Wijerathna, H.M.S.M.; Lee, Sang Hoon; Edussuriya, M.; Choi, Dong-Rack; Kumar, Rajesh

doi:10.1016/j.procbio.2020.03.003

Cited by 30 publications

(13 citation statements)

References 50 publications

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“…Little data is available on the direct use of AuNPs prepared by green chemistry in the treatment of cutaneous candidiasis. Nevertheless, the results of this study are in line with those of the existing studies which indicated the antifungal effect of AuNPs [ 25 , 26 ]. Moreover, the results of this study were consistent with those of the previous studies which revealed that AuNPs bound to the Candida cell wall through electrostatic interactions and released reactive oxygen species that interfered with the signals between cells, caused cell damage, and induced apoptosis [ 3 ].…”

Section: Discussionsupporting

confidence: 92%

Evaluation of the gold nanoparticles prepared by ‎green ‎chemistry in ‎the ‎‏treatment of cutaneous candidiasis

Kareem¹,

Samaka²,

Abdulridha³

2021

CMM

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Background and Objectives: Mineral nanoparticle synthesis via green chemistry is ‎considered a novel ‏procedure ‎that ‎has been introduced into some ‏‎‎industries and medical fields. This ‎paper aimed to focus on ‏synthesized gold ‎nanoparticles ‎‎‎‎(‎AuNPs‎) prepared via green chemistry and ‎their usage in the ‏treatment of cutaneous ‎candidiasis.‎‎ Materials and Methods: This study was performed on the green synthesis of AuNPs using olive leaf extract as a reducing ‎agent‎. The ‎UV‎ visible spectroscopy, X-ray diffraction, and atomic force microscopy techniques ‎were used to detect ‏the concentration of the prepared AuNPs‎. ‎The agar gel diffusion method was used to test ‏the ‎antifungal activity of the ‎‎prepared AuNPs in vitro. ‏Antifungal efficacy of the AuNPs in vivo ‎was tested by the ‎induction of‎‎ cutaneous ‎candidiasis in mice‎. ‎This research was conducted on four groups of mice‎. Groups 1 and 2 were used to evaluate the effectiveness of the AuNPs suspension ‎and ‏Nystatin ointment in the treatment ‎of clinical infection, respectively. Groups 3 ‎and ‎4 were the infected ‎and the non-infected control groups, respectively.‎ Results: Based on the findings, the AuNP synthesis using olive leaves was ‎a suitable and ‎secure method. Moreover, it was found that the AuNP concentration of 40.77 ng‏\‏ml represented the minimum ‎inhibitory concentration for the ‎inhibition of the Candida albicans. The prepared AuNPs were more effective than Nystatin ‎in the ‏treatment ‎of cutaneous candidiasis.‎‎ Conclusion: Preparation of AuNPs via green chemistry using olive leaves as a reducing ‎agent is a ‏safe ‎and easy procedure that can be performed to produce AuNPs. In this study, the AuNPs ‎displayed antifungal ‏activity ‏both in vitro and in vivo.

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Section: Discussionsupporting

confidence: 92%

Evaluation of the gold nanoparticles prepared by ‎green ‎chemistry in ‎the ‎‏treatment of cutaneous candidiasis

Kareem¹,

Samaka²,

Abdulridha³

2021

CMM

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“…Treatment with AgNPs with plant extract presented higher antibacterial activity on gram negative bacteria than positive one and fungus (Aguilar et al., 2018; Baruah, Yadav, Yadav, & Das, 2019; Javan bakht Dalir, Djahaniani, Nabati, & Hekmati, 2020), while AgNPs by using Hibiscus Rosa–Sinensis extract demonstrated better antibacterial activity against Staphylococcus aureus than E. coli (A. Singh et al., 2020). Besides, AuNPs exhibited the antimicrobial activity against E. coli , Bacillus subtilis , and Candida albicans with the MIC of 25, 50, and 32 µg/mL, respectively (Ahmad et al., 2017; Dananjaya et al., 2020). It is interesting that the antimicrobial activity of AgNPs also related to the particle size, which provide different particle size in the range of 10 to 100 nm, in which 80 to 100 nm was given the superior antimicrobial activity than other size (Ginjupalli et al., 2018).…”

Section: Functional Properties Of Nanotechnology‐based Antioxidantsmentioning

confidence: 99%

Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

Myint

Xia

et al. 2021

Journal of Food Science

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Botanic bioactive substances have issues with their solubility, stability, and oral bioavailability in the application, which could be improved by nanotechnologies. In another hands, green synthesis of nanoparticles (NPs) with plant extract is also a promising technology for preparation of NPs due to its safety advantage, yet the bioactive botanic substances that could be more than the assistant of the green synthesis of NPs. Based on the above concerns, this review summarized the preparation of botanic NPs with various plant extract, their solubility, stability, and oral bioavailability; specific attention has been paid to the botanic Ag/Au NPs, their capacity of antioxidant, bioavailability, antimicrobial, anti‐inflammatory, and anticancer.

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“…Husain et al [159] reported that the synthesis of silver nanoparticles using cyanobacteria showed potential photocatalytic activity against dye. Dananjaya et al [160] reported the synthesis of Spirulina maxima-mediated gold nanoparticles and evaluated its cytotoxicity and anticandidal activity. It was found that nanoparticles do not possess any cytotoxicity against cell lines, because they act as potent anticandidal agents.…”

Section: Applications Of Nanomaterials/nanocatalysts 41 Nanocatalysts In Biological Applicationsmentioning

confidence: 99%

Biological Synthesis of Nanocatalysts and Their Applications

et al. 2021

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Over the past few decades, the synthesis and potential applications of nanocatalysts have received great attention from the scientific community. Many well-established methods are extensively utilized for the synthesis of nanocatalysts. However, most conventional physical and chemical methods have some drawbacks, such as the toxicity of precursor materials, the requirement of high-temperature environments, and the high cost of synthesis, which ultimately hinder their fruitful applications in various fields. Bioinspired synthesis is eco-friendly, cost-effective, and requires a low energy/temperature ambient. Various microorganisms such as bacteria, fungi, and algae are used as nano-factories and can provide a novel method for the synthesis of different types of nanocatalysts. The synthesized nanocatalysts can be further utilized in various applications such as the removal of heavy metals, treatment of industrial effluents, fabrication of materials with unique properties, biomedical, and biosensors. This review focuses on the biogenic synthesis of nanocatalysts from various green sources that have been adopted in the past two decades, and their potential applications in different areas. This review is expected to provide a valuable guideline for the biogenic synthesis of nanocatalysts and their concomitant applications in various fields.

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In vitro and in vivo anticandidal efficacy of green synthesized gold nanoparticles using Spirulina maxima polysaccharide

Cited by 30 publications

References 50 publications

Evaluation of the gold nanoparticles prepared by ‎green ‎chemistry in ‎the ‎‏treatment of cutaneous candidiasis

Evaluation of the gold nanoparticles prepared by ‎green ‎chemistry in ‎the ‎‏treatment of cutaneous candidiasis

Bioavailability and antioxidant activity of nanotechnology‐based botanic antioxidants

Biological Synthesis of Nanocatalysts and Their Applications

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